Anthrax has noncriminal uses -- science, for example. Sure, they're unusual, but they're there.
I'm not arguing whether or not megaupload was a good service, or whether or not the government should have cracked down on them. The fact is that the government did crack down on them, and the reason is because they positioned themselves as a great avenue for piracy. If they wanted to survive, they should have either not been so pirate-friendly or found a jurisdiction that didn't care about piracy.
Maybe it would be impossible to accomplish megaupload's goals without being pirate-friendly. Urbit's goals can be accomplished while staying well within the letter and spirit of the law, so there's no point in jeopardizing its success.