I don't have time to spend a lovely Saturday morning watching a 90-minute video just to criticize it, but how can one "debunk" the calories-in calories-out model? Surely this is just plain old thermodynamics?
The answer is that humans are not simple furnaces; different foods are metabolized in different ways, and affect appetite differently.
Discussing diet is hard because everyone reasons from personal experience. E.g., in my experience, almost all my fluid intake is Dr. Pepper and I consume large quantities of the "worst" food, as a proportion of my diet, but I don't eat that much and I work out, so I'm strong and fit with low cholesterol.
His answer is complex, but it all has to do with the introduction of fructose as a macronutrient after the 1970s.
Normally I'd be irritated at this obvious glib objection, but we have to make a physicist allowance in this case :)
The other one you hear all the time is, "But how can fructose be bad? It's in fruit." Gee, do you think he might have thought of that?
Since you're short on time-- the human body processes a calorie of fructose differently than glucose-- it's actually more like ethanol (Maker's Mark in his case).