Once they could make predictions and those predictions were verified by reality. "When I flip this switch the light will turn on.....When I move this magnet past this wire I can shock my lab assistant...."
I don't know much about D&D but I would venture the guess that electrons are far stranger than mana. I mean, not only do they have a wavelength[0], you can do the Double Slit experiment with them[1], but they also have an intrinsic angular momentum and there are rules of which electron can be where based on this "spin"[2]. That's just for starters.
Calling them "mana" (whatever that is) might not be any more wrong than calling them particles.
0 - https://en.wikipedia.org/wiki/Matter_wave 1 - https://en.wikipedia.org/wiki/Double-slit_experiment 2 - https://en.wikipedia.org/wiki/Spin_%28physics%29