I think the first humans on mars will go with the understanding that it's a one-way trip. And there will no doubt be people willing to sign on for that.
I'm also fairly certain they're already quite knowledgeable regarding the effects of weak gravity on the human body.
I suppose we just don't have enough data to say one way or the other.
Edit: an old Nasa article on the topic...
http://science.nasa.gov/science-news/science-at-nasa/2001/as...