Personally I believe the sheer scope is reason enough to reject it on principle as a massive abuse of process.
The problem with saying this,
> Because tons of it is likely to be things that would not pass if they were part of small little individual deals where the vested interests were not so huge.
Is that the thing that potentially would pass would never make it out to see the daylight without negotiation, which is how you get the things that potentially wouldn't pass stand-alone. (And I say potentially, because for every person we're probably talking about different things.)
The larger such an agreement becomes, the murkier it ets. Given the complexity, it will take at least a decade after TPP is ratified before all the implications become clear. We better hope we like the results. But I'll predict that long before that we'll have a string of lawsuits filed over the effects.
(Similarly, once TTIP comes up for ratification, I equivalently expect ratification attempts themselves to be met by a number of legal challenges across the EU, followed by a number of legal challenges over the effects of it; If ISDS is part of a final ratified agreement, I'd expect it take at least a decade to sort out the legal mess alone)