Oh, I think it's possible to be inundated with virtually anything, including relevance. Yes, I may find a product relevant, but there is some threshhold past which I'd be sick of having it pitched to me.
Retargeting is a perfect example of how a relevance beatdown can occur. Yes, I put those shoes in my cart because I was genuinely interested in them. But, I don't need to see them popping up on every site I visit thereafter for a week. Neither do I need to keep seeing the Softlayer Cloud ads, etc. It's a turnoff to be hounded like this, and even distasteful at a certain point.
To your point, though, perhaps part of the problem is the current ad formats.