You said SF, not Silicon Valley.

Degree is not relevant, no one in SV cares. There are plenty of people that don't have college degrees that have very good jobs. All that matters is your skill and competence.

You are in an awkward position. You know Javascript, but you don't know front end. There aren't very many purely backend positions that require only Javascript/Node. They probably expect a complete fullstack knowledge, so not knowing front end will hurt you, and not knowing a more back-end language like Python, Java, etc will also hurt you.

Keep interviewing, but learn a new language, like Python or Java, and try to get some experience in it, through open source projects, freelancing, etc.