The excerpt below is from https://www.nsa.gov/ia/_files/factsheets/I43V_Slick_Sheets/S... (which in turn also references https://www.nsa.gov/ia/_files/factsheets/I43V_Slick_Sheets/S... )
Unix-like Platforms (e.g. Linux, Android, and Mac OS X):
Application developers should use the fread function to read random bytes from /dev/random for cryptographic RNG services. Because /dev/random is a blocking device, /dev/random may cause unacceptable delays, in which case application developers may prefer to implement a DRBG using /dev/random as a conditioned seed.
Application developers should use the “Random Number Generators: Introduction for Operating System Developers” guidance in developing this solution. If /dev/random still produces unacceptable delays, developers should use /dev/urandom which is a non-blocking device, but only with a number of additional assurances:
- The entropy pool used by /dev/urandom must be saved between reboots. - The Linux operating system must have estimated that the entropy pool contained the appropriate security strength entropy at some point before calling /dev/urandom. The current pool estimate can be read from /proc/sys/kernel/random/entropy_avail.
At most 2^80 bytes may be read from /dev/urandom before the developer must ensure that new entropy was added to the pool.