I think MacPorts is a much better tool than Homebrew with way more useful packages. It also installs itself into /opt/local by default so it doesn't conflict with other stuff in /usr/local and for actual OS X or X-Windows apps, it installs them in /Applications. Luckily, they can both live on one system if you're careful, as some people insist on providing only Homebrew copies of their software, which is a bit unfortunate considering that MacPorts is clearly the better system.