I think that the whole ecosystem piggybacking on WP can be matched if not surpassed. There's nothing deficient or lacking in the technologies used in a Node stack to pull this off.

We have npm already to cover the plugins functionality and on the front end it's a framework-a-palooza with libraries and themes popping every other hour.

So, it can be done and I believe it can be easier and simpler whether for the end user or the developer as developing for WP is not really a walk in the park and there's a lot of gotchas and magic involved in this daunting process.