No issues at all but I also don't get motion sickness easily as some people do.
Typing is no issue and when I need to focus, I do slow down and take breaks.
The key is to integrate it within your day slowly, not to go crazy. I wasn't able to do an hour the first day I had this. It took about a month for me to manage an hour and another month to do two and eventually, 4-6 hours with a tiny stretching exercise every once in a while is very easy for me.
In fact, I have problems not using the treadmill. My body wants to walk every day and if I don't use the treadmill, I get really anxious to get out and go for a 10 mile work.
I lost a lot of weight, so this is definitely the most important and totally justified purchase I've done for my home office.
I bought a TrekDesk Treadmill Desk and put it over-top of my actual treadmill. It was a little expensive and quite large, but it works great and I can still run/jog. That's something you don't get with a low HP walking treadmill.