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xlbuttplug2

165 karma · joined February 23, 2023

intentionally depressed
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xlbuttplug2··on All BART trains were stopped due to ‘computer networking problem’
> sad to see continued failures of BART

I think this is overstated, at least from an operations point of view. My mom has been using BART to commute to work for over a year and I can't recall many incidents like this.

xlbuttplug2··on My new deadline: 20 years to give away virtually all my wealth
Surely the people with these knee-jerk reactions lead lives that would hold up under similar scrutiny :)
xlbuttplug2··on AI helps unravel a cause of Alzheimer’s and identify a therapeutic candidate
This stuff goes over my head, but perhaps one can take something to lower TMAO (I see EVOO, allicin, resveratrol, PQQ from a cursory search) to offset choline supplementation. This is assuming TMAO is the cause of increased disease risk and not just a biomarker.
xlbuttplug2··on AI helps unravel a cause of Alzheimer’s and identify a therapeutic candidate
> How are you going to check Gemini’s math on that?

Gemini used 40% choline by weight for alpha GPC and 18% for citicoline, which seems to check out with other sources.

> I’m leaning towards alpha gpc supplements.

I haven't looked into the studies recently, but there have been some negative findings with alpha GPC supplementation[1]. May be worth a gander.

[1] https://examine.com/supplements/alpha-gpc/#what-are-alpha-gp...

xlbuttplug2··on AI helps unravel a cause of Alzheimer’s and identify a therapeutic candidate
> In conclusion, our findings suggest that moderate dietary choline intake, ranging from 332.89 mg/d to 353.93 mg/d, is associated with lower odds of dementia and better cognitive performance.

Gemini tells me that amounts to ~850mg of alpha GPC or ~1900mg of citicoline. Eggs it is then.

xlbuttplug2··on Bill to block OpenAI's for-profit conversion gets mysteriously gutted
inb4 loophole to create a new company and transfer over all the non-profit's assets.. and keep the same name somehow.
xlbuttplug2··on Waymos crash less than human drivers
Off topic, but I've always felt that the ideal way to address safety is by limiting the amount of freedom a vehicle has, i.e., force it to follow a predefined path. That is, replace road lanes with something like tram tracks. (I'm imagining vehicles being two/four person pods zipping around.)

This would vastly reduce the number of accident scenarios, be more efficient, and be much easier to automate. And would probably be good enough for 99% of use cases (i.e., work commute).

Obviously I don't seriously see anyone splurging on the infrastructure and bespoke vehicles for that. But I can dream.

xlbuttplug2··on Gemini 2.5
... which were also written by earlier Gemini versions.
xlbuttplug2··on The serotonin theory of depression: a systematic review of the evidence (2022)
Just a reminder not to impulse buy without first doing some research. IIRC serotonin syndrome is a risk, especially if already on antidepressants.

Some things to note in case you decide to go ahead anyway: https://www.reddit.com/r/Nootropics/comments/28489u/comment/...

xlbuttplug2··on Larry Ellison wants to put all America's data in AI, including DNA
I was more referring to the idea that the journey to attain such wealth requires you to lose a part of yourself along the way.
xlbuttplug2··on Larry Ellison wants to put all America's data in AI, including DNA
If you were to amass 200B, you'd be unrecognizable to your current self.
xlbuttplug2··on Undergraduate shows that searches within hash tables can be much faster
yeah but 1/3 = 0.333 recurring is an equivalent problem to the parent
xlbuttplug2··on Daily omega-3 fatty acids may help human organs stay young
+1. ND and Thorne I trust blindly.
xlbuttplug2··on Daily omega-3 fatty acids may help human organs stay young
Any decent brand is using molecularly distilled fish oil.
xlbuttplug2··on Detrimental Decibels: A Study of Noise Levels in Vancouver's SkyTrain System (2022)
I'd wear noise canceling earbuds or earplugs if I didn't care about keeping track of my surroundings. Hearing loss isn't exactly top of the mind when riding BART :)
xlbuttplug2··on Americans Are Tipping Less Than They Have in Years
Employers save money by convincing the employee that part of their wages are owed by the customer. And as a bonus, when things don't work out, the employee's resentment is directed at the customer instead of the employer. It's brilliant, really.
xlbuttplug2··on Before Squid Game, there was Battle Royale
And the Zero Escape games.
xlbuttplug2··on Ozempic is changing people's skin, say plastic surgeons
But gluttony is a sin!
xlbuttplug2··on Google Pixel 9 Pro
According to the keynote, it notifies the other party that you're using it, which makes sense, but also makes things awkward.
xlbuttplug2··on Scientists discover a cause of lupus, possible way to reverse it
Any particular strain/brand that helped for you?
xlbuttplug2··on Scientists discover a cause of lupus, possible way to reverse it
What was the treatment in your case?
xlbuttplug2··on Exercises to Learn Rust
What do you folks normally do after learning a language like this? (Assuming you don't use it for your day job.)
xlbuttplug2··on Ask HN: Is "systems analyst" still a distinct career?
salmon gutter???
xlbuttplug2··on GPT-4o
people are scared and it shows :)
xlbuttplug2··on Show HN: We built PriceLevel to find out what companies pay for SaaS
> If they are found to add wrong information you can block their account.

How would you prove that a submission is not truthful? You can check if it's an outlier but that's definitely not foolproof.

xlbuttplug2··on Spotify demonetizes all tracks under 1k streams
sputnikmusic is my go-to.
xlbuttplug2··on Long Covid brain fog may be due to damaged blood vessels in the brain
The last para suggests that this is not reversible. But does anyone have any treatment options or supplements/nootropics to recommend?
xlbuttplug2··on Netlify just sent me a $104k bill for a simple static site
Cloudflare got a bunch of new "customers" judging by this thread.

Competitors could rinse and repeat this strategy to put netlify in the dirt for good.

xlbuttplug2··on Show HN: I made a website to find best bus seat to avoid the sun while traveling
... except reversed?
xlbuttplug2··on Show HN: I made TV Sort, a web-based game for ranking TV show episodes
I'd assume this doesn't work too well with shows that aren't episodic in nature. Especially if you binge watch, the line between when one episode ends and the next starts is usually blurred.
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