670 karma · joined February 4, 2017
“This is precisely the area that the researchers, from Imperial College in the UK, targeted with their gene drive system. Males that carry one or two copies of the edited version of the doublesex gene develop perfectly normally and are fertile. Females with only one copy also develop normally. In all these cases, these animals will experience gene editing, and all their offspring will end up receiving a copy of the edited version of the gene from them. And females where both copies have been edited develop with a mix of male and female traits and can't reproduce.”
So the majority of offspring carrying the trait can reproduce. The gene drive mechanism ensures that while the change reduces fitness, it still spreads through the population.
It does this, because even if the gene drive modification only exists on one chromosome, it will copy itself to the other chromosome.
200,000 still seems low. I wonder what fraction of the rat population lives outside the sewers.
For me, there are things that might improve outcomes, but would be unacceptable.
For example, drugs that help with information retention. Mandatory memory enhancing brain implants. Drugs that adjust motivation/focus. Wires attached to eyelids to prevent you from closing your eyes.
The reason why VR used for training seems dystopian is that it removes choice. Or at least feels like it does.
Arguably the trade off is worth it in this case.
Most people, at any income level, would not find value in this book. The fraction of people who find value in the book maybe correlated with income.
There are a large number of people who might benefit from access to this book (or similar books) would can not afford to legitimately purchase it.
Given that only a small fraction of the world population can afford this book (I estimated 5%, happy entertain other estimates) it seems likely that the majority of people that could benefit from access to this book, could not afford to buy it.
I find that unfortunate.
To me you pretty much typify what’s wrong with modern tech culture, a total lack of empathy or understanding that there is a world outside of that which you live.
This is literally the same thing as getting a book from a library. The exact same argument applies.
Throwing Latin around doesn’t progress a discussion.
Maybe 10%, 5%? Other than repeating this obviously wrong statement, would you like to provide some evidence that >20% of the world population can afford this book?
Libraries “steal” money from authors by making books more freely available, in largely the same way that piracy does.
They also make books available to people who otherwise couldn’t afford them.
What you said is more than a select few could afford a $40 book.
The topic being discussed is, the morality of charging so much/piracy.
Good work plugging your github though!
This is in the western world... imagine how many people in the world can’t afford this book. On a global scale... very few people could afford this book (or a 40USD video game).
It makes me kind of sad that you’d so casually suggest that this is not the case. Makes me think that perhaps people in the tech world don’t have a great understanding of how poor many people are...
It’s actually just a shower cap/hat to stop soap getting in kids eyes that’s quite common in Japan. Somebody just put it on their face... I guess as a joke in this instance.
So firstly I agree, $40 seems like a lot. I personally couldn’t justify it at the moment. Particularly when the reproduction cost is nearly zero.
But $40 also doesn’t seem like a lot to pay for a book that will probably not sell more than a few thousand copies. Most likely revenue generated won’t fully cover the time and effort required to create such a book.
But... the author is also a professor at MIT. I feel like if this work wasn’t somewhat publicly funded, it really should have been.
In the end, I’m left morally confused. But it feels like something is wrong in the world when a book like this is available only to a select few, when for the same capital outlay it could be available to everybody.
It’s possibly not as good an outcome for investors, and they might actually view this as a bad exit.
Am I wrong? Would most investors be pretty happy with this? Would most founders/employees be better of going for creating a unicorn?
I’d imagine it would be relatively easy to figure out where someone works and/or lives and just go find them.
Correlating across multiple public databases might make things even easier.
But I don’t think this is the point of the argument. The point is that those in power can gain more benefit from the information than the general population.
Let’s say all votes in elections become public. That information is more useful to a powerful political party than to the public at large, or a small unfunded group. If you don’t want that information abused, the argument goes, you should make sure it’s kept private.
The argument is that even if everybody has access to all information, only a small group is able to exploit that access effectively.
So, you still end up with a small group abusing their access to the information. You should therefore aim for privacy of sensitive information.
I think you’re burnt out for sure. Ideally, you need some downtime to recover. The problem, I’d guess, is that it’s financially not feasible for you to get any.
I just want to say you’re doing really well to keep it together. You don’t need to be doing more right now.
Another commenter recommending making sure your sleep and health are in order. This has helped me for sure. If you can find something that helps give you a sense of achievement (which I’d guess you can’t get from work) that also could help. For me it was blogging, and the interactions that come with that.
I’m still figuring this stuff out too, and it’s not easy. You’re not alone, and don’t be too hard on yourself.
It’s not sustainable for a population to continually apply political pressure on each and every issue. Particularly to lobby against well funded opponents.
The result of a system where we can’t trust elected officals is going to be a failing system. Voters will understand they’re being screwed but won’t understand the issues. So they’re end up voting for someone offering simple solutions, like Trump.
To be fair, Skype also appears to be trying to add a lot of baggage too.
Fixing the issues you list, are part of regaining trust in the political system overall. If it doesn’t get fixed slowly and methodically thing will just get worse and worse until something snaps.
(Ideally with the ability of callout, buy a phone number etc)
Yes when I was younger I would have absolutely refused (it is ridiculous). Now I’m old and cynical and think everything is insane anyway I’d sing it with all my heart... most places are insane, but few are this entertaining!