sithadmin

Even assuming that the contrast could show up in newly excreted CSF (maybe, maybe not), MRI contrast elimination half lives are very short (mostly all under ~2 hrs, excepting cases like renal dysfunction), and cerebrospinal fluid doesn’t replenish particularly quickly.

That just sounds like ASMR, which some folks can induce without external stimuli.

>When I say "the real thing" I mean that they are selling semaglutide, which they are obtaining somehow

>So if they are not getting it from producers under license from NN, where are they getting it?

They're obtaining it from pharma labs with the right equipment and talent to produce it. The synthesis process is well understood, it's not like it's a Novo Nordisk secret.

> Why isn't the legality of that path under active legal attack?

It is.

You're massively misunderstanding that Reddit post, and it doesn't help that the 'HenryMedsInfo' account is misconstruing how the pharma manufacturing supply chain works.

For one, the FDA does not 'license' any manufacturer, period. They do enforce safety and quality standards, but this is not controlled through some sort of a general license, and operates on a per-facility basis.

DMF listing (which isn't a 'license') does not necessarily have any relation to whether that manufacturer is supplying a brand name provider.

The 'license' that account is posting about a complete fiction. There is not a license granted here in any government context, nor a license between NN and the manufacturers the post discusses.

> The compounders are legally selling the real thing directly to customers.

This is debatable. They are not selling 'OEM' NN product to consumers.

Also - stop talking about 'feedstock'. It's weird. It's not standard industry lingo and obscures whatever the hell it is you're talking about (precursors? lyophilized product? something else?)

Victoza (liraglutide)'s patent expired, but its effect on weight loss is pitiful relative to later-generation GLP-1 agonists. Same story for Trulicity (dulaglutide), for which patent protections end in 2027.

Your usage of the term 'feedstock' here is confusing, and it seems like you're probably operating under the erroneous assumption that contract manufacturer supplies commissioned by Novo Nordisk are somehow being routed to compounding pharmacies, which isn't the case.

In practice, there are generic manufacturers for semaglutide, and many other peptides still protected by US patents, mostly located in China. The more reputable of these manufacturers produce these drugs at levels of purity rivaling the 'name brand'. These manufacturers export lyophilized product en masse to middlemen that operate in the grey/black-market 'research chemical' sales market, or ship to compounding pharmacies. The consumers purchasing on the grey/black market reconstitute the drug at home (which requires a trivial level of effort), and assume some extra degree of risk in terms of product purity and sterility. Consumers wanting an extra level of assurance for product quality purchase from a compounding pharmacy that ostensibly is conducting its own assessments of product purity, and following best practices for sterile reconstitution.

I haven’t read deeply into Apple’s standard for digital ID, but I would assume that it’s implemented the way contactless payment via Apple Pay/Google Wallet/other mobile wallets is — rolling tokens that are valid for a single transaction. Skimming attacks are also improbable given that you need to authenticate with FaceID or a passcode for every transaction. It’s not like the phone is constantly blasting out ID/payment card details.

Apple’s implementation doesn’t require unlocking the device, and the ID is validated as a ‘true’ ID rather than just an image through cryptographic exchange over NFC with a compatible ‘ID reader’ device: https://support.apple.com/en-us/118260

Those unions would bargain with...whom, exactly?

The Moaan Plus (available on AliExpress and from other dropshipping marketplaces) also sports an e-ink display in a similar size, is significantly cheaper, and just as functional as a single-purpose e-reader device. Just takes a bit of tweaking to overcome the initially chinese-only interface and sideload a replacement keyboard (the default one is horrendous) and e-reader apps.

Not just by algorithm. In the US, many large employers utilize 'The Work Number' by Equifax for employment verification services, and share details about individual employees as granular as individual paycheck disbursements. This information is visible to other employers that buy in to the scheme, and obviously favors the employer in salary negotiations with a candidate.

Is it really a “crushing blow”? Bowing’s continued success in the commercial aviation sector despite the MCAS issue seems to suggest that they are more or less untouchable. They’re too big to fail, and probably also too big to succeed.

>one of the greatest problem for them is that they bypassed customers deployment policies

Caveat emptor. Falcon and other similar security products often push updates at-will, and they're fully transparent about this if you actually read the contract terms and understand the vendor's approach to operations. I have worked with many clients that elect not to use such tools in certain sensitive environments, specifically to mitigate the risk of being impacted by something like CrowdStrike's 7/19 event.

Along similar lines of thought: there is an Apple Watch case from Japan that replicates the once-popular Infobar 'candybar' phone handset: https://www.multicore.blog/p/infobar-apple-watch-case-review...

Unfortunately the buttons are purely for aesthetics.

Because there's no need to fully evacuate the ISS, which has another 6 years of anticipated operating lifespan, and further, the Starliner capsule isn't equipped to support a deorbit operation?

Intuitively, it would seem that one wouldn't 'aim' a gravitational wave detector. The inputs are omnidirectional, and direction-finding would be accomplished by triangulation based on an array of detectors.

Would depend on what exactly 'vertical integration' is defined as. Most grocers' house brand items are produced by 'white label'/contract manufacturers that supply many different grocers. It's cutting one or at best two steps from the supply chain instead of true vertical integration.

HEB (the major player in the Texas market) is a notable exception that has true vertical integration, with in-house manufacturing and packaging facilities producing house brands, and its own direct relationship with raw goods/farm suppliers.

>Starbucks ultimately bought Clover, and seems mostly to have shut it down

They more or less killed the original model, but they're pushing to deploy the new 'Vertica' model so that drip coffee is brewed on-demand rather than by batch. Ostensibly to reduce waste.

The output from Vertica machines is definitely subpar compared to the original, however.

Stability and bugginess varies wildly from patch to patch.

Definitely not a universal opinion. But it seems pretty common among my physician friends to have fairly specific advance directives that choose death over prolonged (or any) ICU stay in worst-case type scenarios. They keep bugging me to set something up like that for myself.

Je le parle :)

SAMU's program is impressive and shows a lot of promise as a bridge treatment, and it's completely unlike anything available here in the US today (where myself and the friend I mentioned earlier live).

>able to walk and read the newspaper.

Reading the newspaper is a 'maybe' here, but the notion of patients just generally walking around while on ECMO treatment as we know it today is absurd. Letting a patient be ambulatory during ECMO treatment is still in the realm of very, very, very small-n clinical trials, and the risk of near-immediate death from things like a cannula dislodging are very high. Even if it was safe, you're looking at a massive cart of equipment and 1-2 dedicated personnel to walk around with the patient while tweaking its settings.

In general, nobody being treated by ECMO is 'reading the newspaper', if they're cogent and conscious at all. It has absolutely brutal effects on the body, and people are kept sedated while receieving the treatment for good reason.

Yep. A good friend of mine who is a perfusionist (a relatively obscure midlevel med tech role focused on ECMO/CPB operations) has made it clear they would rather just be allowed to die than be subjected to either. The majority of cases they're involved with, but most especially the ECMO cases, per their account, are associated with what seems like unnecessary suffering pending death. Their opinion is that in most cases, it's probably not worth the extreme cost and effort, and that tracking 'survival' as the criteria for success is misguided given poor quality of life afterwards, and usually death related to long-term side effects/complications. They admit that their opinion may be clouded by the fact that they've self-selected into working in hospitals that are the most likely to take 'hopeless' cases, though.

How exactly is a DJI device going to spread propaganda? Fly around with a banner?

The trade jingoism is only part of it. A decade ago, drone tech, including DJI's was far less mature, and not nearly as widely adopted as it is today.

The difference between DJI and Bambu is that Bambu products aren't being used in contexts that convey potentially sensitive information about infrastructure, heavy industry, agriculture, or land development. Bambu has a place in the low end of the market, but anybody doing serious prototyping work in spaces that cross into 'national security' territory is relying on far more specialized and US/Euro-centric vendor ecosystems for additive manufacturing.

DJI does own the consumer segment, but they're also still usually the go-to brand for US commercial purposes as well. Their software and hardware reliability is leaps and bounds better than anything else on the market until you start getting into defense contractor territory.

The US federal government's hostility towards DJI is tangential to its hostility towards drone operators in general. There are real national security concerns about the ability for DJI's devices and software platforms to exfiltrate sensitive data that could be used for military strategy, corporate espionage, or even things like gaining unfair advantages in real estate and infrastructure development deals.

That's not really a fair assessment of the situation. The real (and valid) concern is that DJI's commercial products dominate the market for land/resource development, agriculture, infrastructure, chemical refining and pipelines, and other segments, and the software platform is capable of exfiltrating data (flight telemetry, imaging, etc.) back to a firm with strong ties to Chinese government and state enterprises.

As a moderator of a major technical community on Reddit, I (and the other mods) probably spend more effort on squashing astroturfing campaigns than anything else related to moderation. Removing astroturf posts and banning associated accounts is a daily task. Some vendors are so aggressive about this that we've had to institute automod rules to nuke any post that includes certain brand or product names.

Thankfully most vendors or their marketing agency affiliates that engage in this sort of thing aren't particularly clever about it, so identification of puppet accounts to ban isn't too difficult.