81 karma · joined May 7, 2015
"[...] psilocybin converts to psilocin in the body at roughly a 1:1 ratio by active effect [...]
Psilocybe cubensis (most common): Contains about 0.5-1.0% psilocybin by dry weight. Since psilocybin converts to psilocin in the body at roughly a 1:1 ratio by active effect, 30mg of psilocin would be equivalent to roughly 3-6 grams of dried P. cubensis.
Psilocybe semilanceata (liberty caps): Much more potent at 1-2% psilocybin content, so you'd need only about 1.5-3 grams dried.
Psilocybe azurescens: Even more potent at 1.5-2.5% psilocybin, requiring roughly 1-2 grams dried.
Important caveats:
- Individual mushrooms within the same species can vary by 3-5x in potency Growing conditions, harvesting time, and drying/storage methods all affect potency
- The caps are typically more potent than stems
- Fresh vs. dried makes a huge difference (fresh mushrooms are ~90% water)"
Have to note that the paper is from 2016; for those really interested, it's good to read recent review papers.
There's a paper from Norway that tried end-to-end, but their results were not spectacular. That's the aim of many though, including ECMWF. Note that ECMWF already has their AIFS in production, so AI weather prediction is pretty mainstream nowadays.
Google has a local nowcast model that uses raw observations, in production, but that's a different genre of forecasting than the medium-range models of Aardvark.
The Google model is probably the best so far but ECMWF's own diffusion model was already on par with ENS and many point-forecast models (graph transformers, not diffusion) outperform state-of-the-art physical models.
What is missing is initialization directly from observations. All the best-performing models initialize from ERA5 or other reconstruction.
Google says GenCast forecasts will later be available from them too.
Also ECMWF runs a very similar diffusion model, it's not operational but run a couple of times a day with results available on their graph site (and as data files too I guess): https://charts.ecmwf.int/
(Current) models may of course lack sufficient training data to act on a metalevel enough ("be creative problem solvers"), or they may lack deep enough representations to efficiently act in a more creative way. (And those two may be more or less the same thing or not.)
In general, having low-bandwidth Starlink IoT connections globally accessible would be just great, I can see lots of usage.
The important thing in bayesian (statistical, ML) modelling in general is the ability to gain in flexibility and do model structures that otherwise would be hard or impossible: latent states, hierarchies, etc.
In bayesian NNs the main advantages would be around uncertainty quantification (UQ) and in finding good optima and partly to avoid overfitting. These do apply in some cases of simple NNs.
Mostly however, especially with larger conventional models (not speaking of normalizing flows and such here), using explicit bayes is not feasible. Instead, people use approximate point estimates with tricks:
(1) UQ has been taken care of by post-calibration. (2) Stochastic gradient actually searches for large posterior masses like a variational approximation would do, so it is kind of bayes. (3) And those priors: using dropout is commonplace, it has a bayesian interpretation, and L2 regularization aka gaussian priors are frequent too.
So bayes is there in practice, just not in a neat, pure form but as a collection of practical hacks.
(I have it, discovered by a full-genome sequencing by myself, accidentally around the age of 50.)
Or maybe it's a more fundamental weakness of the attention mechanism? (There are alternatives to that now.)
Some of these forecasts are also downloadable as data, but I don't know whether GraphCast is. Alternatively, if forecasts have a big economic value to you, loading latest ERA5 and the model code, and running it yourself should be relatively trivial? (I'm no expert on this, but I think that is ECMWF's aim, to distribute some of the models and initial states as easily runnable.)
The model has three-level geographical hierarchy from zip-code prefixes, and the local population density as a (hierarchical) covariate. There are also covariances for price level, trend and trend change, and residual model takes number of sales into account and adapts to outliers.
All this helps in getting a better idea of what really happens behind the more or less random individual sales.
http://louhos.github.io/figs/2015-05-07-asuntohintojen-muuto...