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outlace··on Time-Restricted Eating in Patients with Metabolic Syndrome: Study
I think I was fasting too often. I was literally fasting every other day, zero calories only water and black coffee. I probably was slowly losing total body electrolytes.

But I didnt mention this to deter people from fasting, just to be careful. If that fiasco didnt happen to me I'd still be fasting as I felt amazing while fasting. My dad is still doing it for more than a year after I recommended it to him

outlace··on Time-Restricted Eating in Patients with Metabolic Syndrome: Study
Well it happened. I had critically low phosphate which is the hallmark of refeeding syndrome.

And it’s not necessarily an absolute deficiency in electrolytes, it’s that when you break a fast with a carb rich meal, it drives the electrolytes into the cells so there is deficiency of electrolytes in the blood even if total body amount is normal.

outlace··on Time-Restricted Eating in Patients with Metabolic Syndrome: Study
I did intermittent fasting for 2 months, did >36hr fasts at a time about 3 times a week. I felt amazing and saved a bunch of time and money on food. But then I tried doing a 48 hr fast and broke my fast with a big burrito and got refeeding syndrome and was hospitalized for a day.
outlace··on Japanese hotel room costs $1 a night, but you have to livestream your stay
Probably because already rich countries can afford to have high minimum wages in the first place. But many European countries with high minimum wages either by government fiat or because of strong unions have unemployment rates 2 or 3 times higher than the U.S. (e.g. Spain, Italy, Portugal, Sweden, France).
outlace··on Tesla Cybertruck [video]
At first I was like "what the hell is that thing" but it grew on me by the end of the presentation.
outlace··on Homology
In case anyone is interested in delving deeper, I wrote a detailed series of posts on persistent homology including the fundamental math and getting a working python example: http://outlace.com/TDApart1.html
outlace··on Andrew Yang's ideas on automation and mass unemployment are not based in reality
I read the whole thing. It’s not so much that Yang is wrong but that the automation-is-taking-all-the-jobs mantra is incomplete and that outsourcing to places like China is a substantial part of it. From what I can tell from Yang-like arguments outsourcing could be seen as a form of automation. The general idea is that companies are incentivized to reduce labor costs so whether it’s outsourcing or automation the end result is the same. Presumably if we restrict outsourcing then just more investment into automation will take place. It’s inevitable.
outlace··on The Future of Mathematics? [video]
I watched the whole thing and it was fantastic. Professor Buzzard is an excellent presenter. I downloaded Lean and started playing around with it after this lecture.
outlace··on Quantum Supremacy Using a Programmable Superconducting Processor
I guess you're right, I remember seeing quantum algorithms that were assumed to be more efficient than any classical algorithm and then people devised equally efficient classical algorithms. E.g. work by Ewin Tang https://arxiv.org/abs/1811.00414
outlace··on Quantum Supremacy Using a Programmable Superconducting Processor
What's the chance someone will come along with a classical analog that matches/beats this result? I remember seeing claims of quantum supremacy in the past and then clever people invented new classical algorithms that performed just as well.
outlace··on Psychiatric Diagnosis Found to Be “Scientifically Meaningless”
Perhaps I should have said biologically meaningful. Yes ASD, schizophrenia, bipolar and ADHD are heritable at around 0.8, impressive. But there's also a good amount of research showing that mental illness in any form is correlated and there is a "p factor" that seems to predispose people to mental illness in general. There could be many possible genetic variations that lead to the same DSM diagnosis. Similarly multiple neural derangements can lead to the same set of symptoms. And research based on brain imaging (e.g. https://www.nature.com/articles/s41467-018-05317-y) suggests that our DSM diagnoses are probably not mapping reliably onto underlying brain dynamics. Plus, if I just randomly throw together a set of symptoms e.g. {back pain, chronic bloating, insomnia}, I wouldn't be surprised if it was heritable at 0.3 or above given that whatever genes are involved are going to get passed down and often genes sit next to each other on the same chromosome etc.

The exciting research I care about is more along the lines of < https://www.ncbi.nlm.nih.gov/pubmed/30696271 > where we observe neural dynamics, hypothesize causality, intervene with TMS or other focal neuromodulatory tech, and see if in fact region A is causally linked to outcome B, or if neural dynamical state A is causally linked to outcome B.

I also meant that the DSM is biologically unreliable because it is only symptom clusters, and we cannot intervene at the level of symptoms, you have to intervene at the level of pathology. Symptoms are not pathology. It's the brain that is experiencing some pathology, so we need to ascertain the brain pathology and intervene at that level, and DSM, as noted by brain imaging studies, does not seem to reliably map onto that biology.

Aside, are you involved in software engineering? What brings you to HN?

outlace··on Psychiatric Diagnosis Found to Be “Scientifically Meaningless”
You’re absolutely right. But the brain is a biological organ, a biological information processor. Experiences shape it’s physical structure and function. Whether mental illness arises from purely environment causes (eg trauma) or purely nature (eg genetics, physical injury), in both cases the phenomena reside in the physical substrate of the brain.

When someone has psychosis (eg hearing voices), maybe it was caused by a severe trauma or maybe it was mostly genetic. In either case the person is suffering from psychosis and is unable to normally function in society (if severe enough). In both cases, in principle, we should be able to detect the problem at the level of the brain in structure and function, and should be able to intervene at the level of the brain.

The intervention required depends on the nature of the brain change. We can change brain function in many cases by intensive therapy. In some cases sensory inputs alone (via talk therapy) are insufficient to change the brain to rectify an issue. That’s when we have to consider direct intervention on the brain itself either via medications or neuromodulation technology.

I don’t think lay people understand how profoundly mentally ill some people are and that they can really have dramatic improvements with treatment. Lay people think of psychiatrists just peddling drugs to mildly depressed patients or people who are mildly oddly behaved. That’s just not the case. I’m working with people who sometimes literally stop eating because they think their food is poisoned, or attempt to kill themselves with minor frustrations, etc. And many patients, mostly not that sick, come in voluntarily because they feel they can’t handle some problem on their own. You’re right that much I mental illness is caused by psychosocial stressors, but some people have just intractably messed up life situations and they’ve just spiraled downward as a result and wouldn’t be able to get on a better path without treatment.

outlace··on Psychiatric Diagnosis Found to Be “Scientifically Meaningless”
It’s actually fairly uncontroversial between psychiatrists that the diagnoses as specified in the DSM are not biologically valid.

We use them more as a communication tool to give a rough picture of a patient’s symptoms to other providers than as a map onto biology. We simply don’t understand the underlying biology well enough yet to do any better. But there’s a lot of exciting research cracking this area open and we may very well be able to diagnose and prognose based on objective data such as brain imaging, genetics and blood tests.

Psych resident

outlace··on Exploring Weight Agnostic Neural Networks
My inspiration comes from this: https://arxiv.org/pdf/1809.06303.pdf

There's a long history of using differential equation models to model high-level brain function (see also neural mass models and neural field models) but I think there are advantages to using discrete time approximations such as neural networks in an RL setting to investigate how the dynamics (e.g. attractor states, etc) map onto behavior.

outlace··on Exploring Weight Agnostic Neural Networks
I’m most excited about what is now being called scientific machine learning, ie machine learning models explicitly structured to learn interpretable models that can be used to understand some scientific domain better. For example, I’m starting to work on using graph RNNs to study dynamical behavior of reinforcement learning agents and how it might give us insights into psychiatric disorders.
outlace··on Ask HN: Best resources to gain math intuition?
I was obsessed with topological data analysis which is basically applied algebraic topology, so I read every paper I could find on TDA. All of them were mostly incomprehensible to me at first, but by working backward, e.g. "What's a homology group?" Oh I need to learn some basic group theory first. Oh what's a Cayley graph? I kept working backward and forward until I could piece it all together. Working backward from a specific goal was very motivating compared to just working through a textbook aimlessly.
outlace··on Ask HN: Best resources to gain math intuition?
Try finding a cool research paper that contains a lot of math you don’t understand. Then spend a few months learning the math in that one paper until you get it. That is a highly motivating and enjoyable way to learn. Far better than textbooks. I did this to learn algebraic topology.
outlace··on Singapore Says Musk's Electric Cars Are About 'Lifestyle,' Not Climate
Even if electric vehicles do not substantially reduce greenhouse gases, they do pollute the air far less assuming you have cleaner electricity generation.

Moreover, ending the reliance on unsustainable fossil fuels is an end in itself. It would reshape global geopolitics and of course there’s a ton of destruction that happens from oil spills and oil extraction. Going full electric has many benefits beyond just reducing greenhouse gases.

outlace··on Is involuntary treatment for mental illness allowed under CRPD?
The prevailing evidence suggests ECT does not appear to cause significant permanent long term cognitive impairment

https://www.sciencedirect.com/science/article/pii/S106474811...

https://www.ncbi.nlm.nih.gov/m/pubmed/2053635/

https://www.ncbi.nlm.nih.gov/m/pubmed/28617690/

outlace··on Is involuntary treatment for mental illness allowed under CRPD?
That's completely absurd, at least here in the U.S. If a psychiatrist involuntarily admitted someone just because the patient believed in a conspiracy theory they should be rightfully sued by the patient and would certainly win the case. That would be gross malpractice.

Moreover, there is no incentive for psychiatrists to be admitting people inappropriately. Psychiatrists are physicians and want to feel like they're actually doing something useful like everyone else. I have no interest in admitting a patient that doesn't have a treatable illness. There are plenty of patients with real illnesses to treat.

outlace··on Is involuntary treatment for mental illness allowed under CRPD?
That's just wrong. I have seen many patients request ECT (many of them are well-educated) because they've tried everything else and are medication resistant. It's only significant side effects are temporary memory issues. ECT should be used more not less, it is way safer and more effective than many medications psych or not.

Patient's are typically brought into a surgical suite, put to sleep and given paralytics as if they were having a surgery. The brain is shocked for like 10 seconds, the patient is asleep and paralyzed, no convulsions happen, no discomfort to the patient. The anesthetics wear off in a couple minutes, the patient wakes up and is able to go home, just as if it were some minor outpatient surgery.

outlace··on Is involuntary treatment for mental illness allowed under CRPD?
Resident psychiatrist here. That is simply not true. [See similar comment below]. I'm a resident psychiatrist, almost all patients we admit at my institution sign in voluntarily. The times we involuntarily admit patients are when they are so symptomatic that they would very likely die without treatment (e.g. they refuse to eat because they think their food is poisoned).

Psychiatrists have no interest in detaining people, quite the opposite. Most of the time I'm dealing with patients who are feigning symptoms e.g. pretending to be suicidal to get admitted because they're homeless, and so we have to admit them lest we get sued, despite the fact there is good evidence many times an admission would be counter-productive. You have people who will sue psychiatrists if they don't admit someone and that person ends up killing themselves, and you have people who think psychiatrists are wantonly admitting too many people.

Also there's nothing dubiously ethical about ECT. It's one of the safest procedures in psychiatrist and the most effective. Many many patients consent to do ECT voluntarily.

outlace··on Is involuntary treatment for mental illness allowed under CRPD?
Sure, but the idea is that if someone is schizophrenic and threatening people, it would be better for the patient and society if she was admitted to a psych unit and treated, and possibly able to return her life, rather than incarcerating her for some time, releasing her untreated and then the same thing happening again and now she has a criminal record.

As a resident psychiatrist, I can tell you that most of the time I'm not conflicted about involuntarily admitting a patient, at my institution it happens rarely, almost all patients sign in voluntarily and can request to leave, in fact most of the time we deal with patients who actually want to get admitted and will feign symptoms to do so, forcing us to admit them. The times we involuntarily admit patients are when they are so symptomatic that they would very likely die without treatment (e.g. they refuse to eat because they think their food is poisoned).

Every field has its history of controversies, that doesn't mean the field as a whole is inherently bad.

outlace··on Giving up on Julia (2016)
Julia isn’t yet ideal (but looks like this will be addressed soon) if your code will run in less than 30 seconds in eg Python, but anything taking longer than that would probably benefit from using Julia. So for most machine learning/data science projects Julia may offer a significant advantage over Python or R.
outlace··on CEO compensation has grown 940% since 1978
I wonder if there is a market explanation for this rather than "CEOs are more evil and greedy now" that seems to be the dominant talking point. Perhaps running a company now requires more skills than it did the 1970s and before and yet there are not proportionally more skilled people. Just like software engineers are paid a lot because it's a high skilled job and the proportion of people with the talent and skill to be a software engineer probably hasn't increased correspondingly.
outlace··on Become a nurse or physicians assistant instead of a doctor (2012)
I also happen to be a programmer, worked part time as a web programmer in college and continue to write code for research projects. I’m interested in applying machine learning to problems in healthcare, most recently.
outlace··on Become a nurse or physicians assistant instead of a doctor (2012)
It’s difficult to switch residencies because each residency program has a fixed number of positions per training year which is largely funded by the government. And almost all positions are filled by the end of match so the only way you can switch is if someone leaves their position for some reason and they happen to be at the same training level as you.

Medical schools admit a variable number of students each year although they aim to have a specific number. It’s difficult to switch medical schools because Med school curricula are very different from program to program. And also there’s just no standard mechanism for switching, you’d just have to schmooze some of the higher up administrators. Med schools don’t really get any advantage by taking in transfers unless they had a mass exodus of students and needed the money. So there’s little incentive for administrators to even bother with transfers. In residency you want all your positions filled so you can keep the funding and have enough staffing so if a position opens you want to fill it ASAP.

outlace··on Become a nurse or physicians assistant instead of a doctor (2012)
The pre-clinical years (usually the first two years, but many schools are condensing this phase into 1 or 1.5 years) are very meritocratic in that your standing depends on mostly multiple choice tests. And then you take the first medical licensing exam called Step 1 which largely determines your competitiveness for residency programs. The clinical years where you are actually working in the hospital in various fields is less objective as you are judged based on the subjective feedback evaluations of the residents and attending physicians.

However, you are mostly rated on how much you know, how confident you are and your social skills. So if you did really well in the pre clinical years and are not socially inept then you’ll probably get good evaluations.

But it’s a marathon. It’s an unbelievable amount of information you have to memorize and in the beginning it’s hard to stay motivated when you can’t see it’s direct relevance.

So overall I’d say it’s fairly meritocratic. If you can memorize things well and are social then you’ll do well barring any exceptional circumstances.

outlace··on Become a nurse or physicians assistant instead of a doctor (2012)
New resident physician in the U.S. here. I actually really enjoy my job now but absolutely hated medical school. Would I do it again? Probably not even though I’m happy now. Four years of misery during my twenties was not worth it. And the stress of $250,000+ of student loans is ever present. And unless you’re at the top of your class at every stage of training, you have little control over where you end up geographically which is really bad when you have relationships to maintain. Long distance for several years sucks a ton.

So I’d only recommend going to medical school if you’re a top student who can get scholarships (so you don’t have much debt) and so you have some control over where you go (because you’ll be competitive for most programs). But even so, I went to a top Med school which was my first choice and I still ended up hating it. You’ll never know what program/city you’ll like until you try it but once you start it’s very difficult to change Med schools or residency programs in general.

outlace··on BiVector: Community for Geometric Algebra for CGI, Vision and Engineering
Why isn’t geometric algebra more popular when it is described glowingly as “the most powerful language for mathematical physics”? (Honest question)
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