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omar_a1

106 karma · joined June 4, 2019

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omar_a1··on Climate change driving entire planet to dangerous 'global tipping point‘
Oh, I stand corrected: Indoor plumbing will only take 347,000 years.
omar_a1··on Climate change driving entire planet to dangerous 'global tipping point‘
30 years is an underestimate. Homo sapiens have been around 350,000 years. We've only had indoor plumbing for the last 200 or so.

It took 349,800 years for us to install a toilet. Constructing a pyramid took 346,000 years. Granted, the survivors of climate disaster will have the benefit of legacy technology, but surviving in these new conditions well enough to create a society capable of widescale adaptation of our current society's abilities will take several thousand years at best. As they say, Rome wasn't built in a day.

omar_a1··on Climate change driving entire planet to dangerous 'global tipping point‘
Don't forget the ridiculous propaganda being pushed by the fossil fuel industry, if the slew of climate denialist rebuttals to your comment are any indication...
omar_a1··on Ask HN: Is there anything I can do to get severance? Please help
Do file for Unemployment Insurance. It might not apply to your role or circumstances, but it's worth exploring if you don't have savings. (NB: Some employers reject legitimate unemployment claims as a matter of course. It often may be successfully appealed even without a lawyer, but the appeals process can take months.)
omar_a1··on The Higher States of Bromine
I fail to see how quickly shutting the hood in cases of catastrophic failure address my concerns. When you're dealing with pressure differentials and compressed gasses, explosions and implosions are a very real risk, and shutting the fume hood, even quickly, will not help in the fraction of a second these failures would take to fill your lab with aerosolized HF and shrapnel.

Even working at negative pressures, you can easily end up with a positive-pressure manifold if your sample is unexpectedly evolving gas at a higher than usual rate, or your valves aren't configured as intended. To be clear, these aren't academic exercises; I've actually seen all of these happen. With closed systems, you have to anticipate explosive pressures and plan accordingly. HF is incompatible with that kind of failure.

omar_a1··on The Higher States of Bromine
Only if we ignore that HF is volatile, meaning that you're dealing with much more (not dissociated) HF evolving from your reagents. Even with a fume hood, you've got much more HF in your face versus a 5% concentration. Calcium gluconate gel will do nothing for HF in your lungs.
omar_a1··on The Higher States of Bromine
As in, a highly pressurized gas canister? In a container that is presumably 100% impervious to HF corrosion, yet somehow also made out of a material that can withstand those pressures?

How is that safer than neutral-pressure, aqueous HF? I'm perfectly comfortable with bottled HF, to the point that I literally handled it in the dark (light-sensitive samples), but I'd never set foot in the same room as a pressurized HF gas canister. A spilled HF bottle is a major incident, but ultimately straight forward to contain, whereas an HF canister leak would kill off an entire lab.

I've done enough manifold setups and worked with enough gas cylinders to understand that they can leak in all kinds of ways, even with a wealth of experience. As I said initially: you are definitely not paranoid enough about this setup.

omar_a1··on The Higher States of Bromine
I think you're not paranoid enough about HF. It doesn't wash off, and is small enough to pass through skin to form insoluble mineral precipitate with calcium in bone and blood, which can result in amputations from dead tissue. It's one of the few acids capable of eating through silicates in glass or rock.

Even at lower concentrations, you still need specialized gloves, apron, and ideally a face shield, in addition to standard PPE. Source: worked with HF for 3 years.

omar_a1··on Ask HN: How to get into genetic engineering if I have no formal background?
Start with an entry-level job in an MCB lab (standard bench work: pipetting, plating, PCR/PAGE, wet chemistry, etc.), and build upon that experience to get opportunities to do more sophisticated techniques, eventually leading to genetic engineering work.

Essentially, the path I'm recommending is a career in microbiology. It's admittedly the long road, and not a well-paying one at that, but it's one way to do it!

omar_a1··on Ask HN: Do animals grasp the concept of solid-liquid-gas?
Yes, but did they understand that the change occurring was a physical one, rather than a chemical one? As opposed to cooking other forms of food and beverage save for ice, which would fall under chemical reactions rather than phase transition.
omar_a1··on Ask HN: Do animals grasp the concept of solid-liquid-gas?
My money's on No, because of a slightly related psychological concept: conservation.

Conservation is the cognitive understanding of whether or not the amount of a given (inert) solid or liquid will change despite its presentation. For example, human toddlers don't grasp conservation, and will erroneously believe that pouring water from a tall glass into a wide bowl makes more water, since it "looks" bigger in the wider container (e.g. it takes up more visual space in a wider vessel, and therefore must be "more"). No other animals possess this skill either (thank you Wikipedia [0]).

Combine that with the nebulous nature of gas - it's not intuitive to understand that an empty glass is, in fact, full of air - and understanding phase changes become that much more difficult.

It's kind of like how most people won't intuitively understand how discrete phases can break down at higher temperatures and pressures, or the differences between different lattice configurations of the same substance. If it's not something we encounter every day, or aren't taught at an early age, the intuition simply won't be there.

[0]https://en.wikipedia.org/wiki/Conservation_(psychology)

omar_a1··on 0.30000000000000004
It has! See: https://news.ycombinator.com/item?id=21687225
omar_a1··on 0.30000000000000004
To be fair, this is also done in every other STEM field, and CS is no exception.

We could all learn a lot more from each other if everything wasn't a contest all the time.

omar_a1··on Ask HN: Why do so many startups claim machine learning is their long game?
I've seen so much bad math and misunderstood statistics hard coded into widely-implemented software that that's not ideal either.

Ultimately, you need a team with a combination of strengths if your product requires multidisciplinary work. Otherwise you end up with hilariously wrong equations/assumptions in your code base. But, full disclosure, my background is math/science.

omar_a1··on Ask HN: Getting started in biology with a software background
Genetics and evolutionary ecology falls into the category of "layers of abstraction." Mechanisms for up and down-regulation, self-catalysis, epigenetic.

You're convoluting the simplicity of each step of an experiment with the level of complexity of the field itself. Memorization is a crucial component, but if you believe that's all there then you are severely underestimating the study of life. It would be like claiming that since CS can be boiled down to 0's and 1's that it is therefore a simple field of study.

omar_a1··on Ask HN: Getting started in biology with a software background
I'd say there's no subtitute for hands on experience. In the same way people on here recommend writing your own project to learn a language over simply reading about it, actually doing lab work gives you an understanding that no biology textbook can provide.

I vehemently disagree with the claim that biology is a simple field, and I'm especially surprised to hear this from someone who did work in this field for 11 years. Anyone who has taken an intro biochem class would back me up on this: life is complicated!

omar_a1··on Ask HN: Getting started in biology with a software background
I was coming into this thread to recommend looking for entry level part time mcb/bio lab work precisely because of point #1.

It's a wax on, wax off thing. The repetition gives you a chance to reflect on the rationale for your technique and bigger picture of what you're doing, in addition to getting hands-on experience in the field.

omar_a1··on Ask HN: What advances in chemistry make super efficient cleaners possible?
Solvation is part of it (particularly for soaps and mineral spirits), but the main factors are oxidation and, as you stated, acid/pH. Oxidation removes organic stains (e.g. foods, mold-stains) and, depending on the strength, disinfects (e.g. Bleach). Mutually exclusive from oxidizing cleaners, acid-based cleaners dissolve insoluble inorganics (lime/rust build-up).
omar_a1··on Ask HN: I can’t pass tech screens, Should I change careers?
I've had this happen too. Also, lots of vagueness about what the technical interview entails, whether in terms of tech stack, format (Q&A? Coding exercises? Discussion-based?), or domain of questions (Pure algorithms? Specific applications to role? Both?).

And even when they are specific, it's not very accurate since there's a game of telephone from the person administering the test and the recuriter.

I study hard, I learn new languages and skills, only to get a completely different test. If I'm studying for the LSAT and am handed the MCAT, it's not a realistic indication of performance.

omar_a1··on Ask HN: I can’t pass tech screens, Should I change careers?
I'm in the same boat. I know I would do the job well, but I'm not a good test-taker. And even when I manage to perform really well on the tech screen, I still get rejected.

Stay strong, OP.

omar_a1··on Ask HN: Does reading about climate change give you anxiety or depression?
Would have flagged, but didn't realize it was possible (not at the karma threshold). Will keep in mind for future reference.
omar_a1··on Ask HN: Does reading about climate change give you anxiety or depression?
No dear, you're just trying to legitimize the 'White Genocide, protect our pure race' Nazi rhetoric by playing the victim. (Nice co-opting of the word "gaslighting" by the way. Very convincing!)

Calling out your bullshit is not shouting abuse at you, and it's definitely not condoning it. And, for the record, people shout "Fuck Muslims" and similar sentiments all the time. With much greater frequency. Often right to my face.

So, welcome to the club buddy!

Edit: Also, this gem: "shouting 'fuck white people!' might get you a job"? This isn't Stormfront, be coherent.

omar_a1··on Ask HN: Does reading about climate change give you anxiety or depression?
Yes, why won't anyone think about the plight of the White Supremacist anymore. Just awful.

What fucking year is this again?

omar_a1··on Arctic sea ice reaches second lowest minimum in satellite record
This is assuming we act before any of the global homeostasis mechanisms break due to the CO2 levels (jet stream, thermohaline cycle, methane clatharates, etc. etc.), in which case it'll take far more money (and research).
omar_a1··on Arctic sea ice reaches second lowest minimum in satellite record
We can fund the God damn research, for one. Of course, for that we'd need a functional government.
omar_a1··on An important quantum algorithm may be a property of nature
"what is already well known and understood via Chemistry, and sure some of that is inherently just fronting quantum mechanics behind the scenes."

This is actually my main point. I'm not intending to reduce or dismiss (bio)chem through the lens of applied physics. I'm saying that anyone competent in biochem understands these properties on an intuitive level, and further understands that the root of these systems' behavior lies in quantum mechanics, even if they're not crunching wave equations on a daily basis. (That said, discussing s and p orbitals are a pretty routine part of figuring out organic reaction mechanisms.)

The field considers the quantum effects on these systems as a matter of course - as with your example about ion channel flow and caveats on bulk properties versus a single ion. There's still no question that quantum mechanics affects these systems, it's just a question of when it needs to be factored in to not throw off the calculations, and when the scale is large enough that its effects can be considered negligible.

omar_a1··on An important quantum algorithm may be a property of nature
Maybe I'm just using a less narrow definition of quantum mechanics? I'm not referring to the specific quantum phenomena referenced in the article, but to quantum mechanics in general. In other words, since these redox steps are happening on a molecular scale, that of course quantum mechanics falls under its purview - as would anything else happening on this small of a scale.

For instance, not factoring in steric factors (e.g. uncertainty principle) or electron tunneling in the transfer of electrons during photosynthesis or cellular respiration would probably throw off your models. Biochemists are well aware of this; you couldn't effectively understand chemistry without understanding quantum mechanics.

omar_a1··on An important quantum algorithm may be a property of nature
I was also confused about the assertion that biologists dismissed quantum mechanic's affects on biological systems. Biochemists have known about this phenomenon for decades, including photosynthesis.
omar_a1··on Ask HN: Are you ok?
Hey, thanks! =D
omar_a1··on Ask HN: Are you ok?
I've been unemployed for four months now. And, ironically, have been overworked preparing for the slew of technical interviews I've had these past two weeks (four just this week). If you had asked me this question a few weeks ago, when I had zero job prospects, I would have said no, but being busy again is giving me a newfound sense of purpose. Let's hope at least one of these interviews pans out! Fingers crossed!
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