HNHacker News
TopNewBestAskShowJobs

neuronexmachina

2,070 karma · joined October 30, 2013

submissionscomments
neuronexmachina··on Codeberg Reaches 300k Projects
> It seems like developers, of all people, are willingly letting their code be AI piggybacked.

Is Codeberg actually effective at preventing crawling of public code they host?

neuronexmachina··on Claude Sonnet 4.5
I think coding is also the area where companies are most likely to buy large team licenses.
neuronexmachina··on U.S. hits new low in World Happiness Report
Xenomorph Queen
neuronexmachina··on U.S. hits new low in World Happiness Report
* Direct link to 2025 report: https://www.worldhappiness.report/ed/2025/

* Rankings: https://data.worldhappiness.report/table

* Data for the US specifically: https://data.worldhappiness.report/country/USA

The main thing I found interesting was the big jump in "Benevolence" for 2020-2021, presumably related to the pandemic.

neuronexmachina··on That Secret Service SIM farm story is bogus
Reading between the lines, my guess is something like this happened:

* some of the US government officials protected by the Secret Service were the targets of swatting

* the USSS found the swatting calls were anonymized by a SIM Farm in/near NYC

* their investigation of the SIM Farm found "300 co-located SIM servers and 100,000 SIM cards across multiple sites"

* it could have hypothetically been used for swatting officials at the UN General Assembly, but that seems to be conjecture by the Secret Service, rather than anything they actually have evidence of

Does that seem consistent with what we know?

neuronexmachina··on US Government seeks deportation of Mahmoud Khalil (again)
It's crazy that he's a permanent resident and hasn't even been accused of a crime.
neuronexmachina··on Immunotherapy drug clinical trial results: half of tumors shrink or disappear
Direct study link: https://www.sciencedirect.com/science/article/pii/S153561082...

> Fc-optimized CD40 agonistic antibody elicits tertiary lymphoid structure formation and systemic antitumor immunity in metastatic cancer

> CD40 agonism enhances antitumor immunity but is limited by systemic toxicity and poor efficacy. Here, we present a phase 1 study (NCT04059588) of intratumoral (i.t.) 2141-V11, an Fc-engineered anti-CD40 agonistic antibody with enhanced binding to the inhibitory receptor FcγRIIB. Among 12 metastatic cancer patients, 2141-V11 was well tolerated without dose-limiting toxicities. Six patients experienced tumor reduction, including two complete responses in melanoma and breast cancer. 2141-V11 induced regression in injected and non-injected lesions, correlating with systemic CD8+ T cell activation and mature tertiary lymphoid structures (TLSs) in complete responders. In CD40/FcγRs humanized mice bearing orthotopic tumors, i.t. 2141-V11 promoted de novo TLS formation, facilitating i.t. CD8+ T cell effector responses independent of lymph node priming. The resulting local immune responses by 2141-V11 mediated abscopal antitumor effects and sustained immune memory. These findings demonstrate that i.t. 2141-V11 is safe and promotes immune-privileged tumor microenvironments that promote systemic and durable antitumor immunity.

neuronexmachina··on Immunotherapy drug clinical trial results: half of tumors shrink or disappear
Worth noting that all 12 were already metastatic cancer patients, so they probably already had a rather low 5-year survival chance. I'm under the impression that seeing even a partial tumor response is pretty striking.
neuronexmachina··on U.S. Supreme Court Allows Racial Targeting ICE Raids to Continue in LA
I think the dissent said it pretty well:

> A Federal District Court found that these raids were part of a pattern of conduct by the Government that likely violated the Fourth Amendment. Based on the evidence before it, the court held that the Government was stopping individuals based solely on four factors: (1) their apparent race or ethnicity; (2) whether they spoke Spanish or English with an accent; (3) the type of location at which they were found (such as a car wash or bus stop); and (4) the type of job they appeared to work. Concluding that stops based on these four factors alone, even when taken together, could not satisfy the Fourth Amendment’s requirement of reasonable suspicion, the District Court temporarily enjoined the Government from continuing its pattern of unlawful mass arrests while it considered whether longer-term relief was appropriate.

> Instead of allowing the District Court to consider these troubling allegations in the normal course, a majority of this Court decides to take the once-extraordinary step of staying the District Court’s order. That decision is yet another grave misuse of our emergency docket. We should not have to live in a country where the Government can seize anyone who looks Latino, speaks Spanish, and appears to work a low wage job. Rather than stand idly by while our constitutional freedoms are lost, I dissent.

neuronexmachina··on Adaptive LLM routing under budget constraints
I tried it in Gemini just now, it seems to have done a decent job: https://g.co/gemini/share/b6fef8398c01
neuronexmachina··on White House fires CDC director Monarez after she refuses to resign
Yep. He was forced to pull his first nominee for CDC director due to the nominee being an anti-vaxxer: https://www.politico.com/news/2025/03/13/dave-weldon-vaccine...

> Weldon, a Florida representative from 1995 until 2009, has been critical of the federal government’s oversight of vaccine safety. While in the House, he sponsored a bill that would have taken vaccine safety oversight from the CDC and created a separate “Agency for Vaccine Safety Evaluation” under HHS, and as recently as 2019 repeated the disproved claim that “some children can get an autism spectrum disorder from a vaccine” in an interview.

neuronexmachina··on Uncle Sam shouldn't own Intel stock
Is this even legal? As far as I can tell, there's no provision in the CHIPS Act allowing grant funds to be used to buy equity.
neuronexmachina··on AGENTS.md – Open format for guiding coding agents
That's sort of this? I guess the exact behavior would depend on the agent.

> Place another AGENTS.md inside each package. Agents automatically read the nearest file in the directory tree, so the closest one takes precedence and every subproject can ship tailored instructions. For example, at time of writing the main OpenAI repo has 88 AGENTS.md files.

neuronexmachina··on Claude Opus 4 and 4.1 can now end a rare subset of conversations
The cluster visualization of the interactions which Claude Opus 4 found "distressful" is interesting, from pages 67-68 of the system card: https://www-cdn.anthropic.com/07b2a3f9902ee19fe39a36ca638e5a...
neuronexmachina··on ADHD drug treatment and risk of negative events and outcomes
> I wouldn’t be surprised if this study were funded by some pharmaceutical lobbying shell organization.

Funding info is at the bottom of the article, the project was primarily funded by the Swedish government.

neuronexmachina··on Alaska's Juneau orders evacuations as record glacier flood looms
A couple notes about that release:

* It focuses on "industrial emissions", which in their analysis doesn't seem to include agriculture

* It's largely indirect emissions, e.g. if someone uses gas in their car from a gas station which was refined from crude oil purchased from Saudi Aramco.

neuronexmachina··on Cursor CLI
I haven't tried it yet myself, but I noticed their product page (https://cursor.com/cli) says:

> Set your own rules: Customize Cursor's work with rules, AGENTS.md, and MCP.

There's no mention of it in the docs, though. It's also interesting it's AGENTS.md on that page instead of AGENT.md, I wonder if that's a typo.

neuronexmachina··on Cursor CLI
I really like the idea of standardizing on AGENT.md, although it's too bad it doesn't really work with the .cursor/rules/ approach of having several rules files that get included based on matching the descriptions or file globs in frontmatter. Then again, I'm not sure if any other agents support an approach like that, and in my experience Cursor isn't entirely predictable about which rules files it ends up including in the context.

I guess having links to supplementary rules files is an option, but I'm not sure which agents (if any) would work well with that.

neuronexmachina··on GPT-5 for Developers
> That said the reality is in my experience the only models that actually work in any sort of reliable way are claude models.

Anecdotally, the tool updates in the latest Cursor (1.4) seem to have made tool usage in models like Gemini much more reliable. Previously it would struggle to make simple file edits, but now the edits work pretty much every time.

neuronexmachina··on Gemini CLI GitHub Actions
I think this would be API-based pricing, while Gemini Code Assist is flat-rate. I'm not sure what other differences there are, though.
neuronexmachina··on Jules, our asynchronous coding agent
Tangentially, last week I asked Gemini's research mode to write up a strategy guide for a videogame based on a 20-episode "masterclass" youtube series. It did a surprisingly good job.
neuronexmachina··on At 17, Hannah Cairo solved a major math mystery
> The breadth of education is a shallow survey at best that is quickly forgotten exactly one semester later.

Your own experience isn't generally applicable. Although it was a couple decades ago, I still use various things I learned from my non-major classes pretty much daily.

neuronexmachina··on Try the Mosquito Bucket of Death
Does it actually attract mosquitoes? I didn't think they'd be attracted to UV light.
neuronexmachina··on Ask HN: Why do Cursor, Windsurf and Claude Code dominate the conversation?
> As per another comment Gemini CLI and OpenAI Codex have more stars, and they're both much larger companies.

The GitHub repos for Claude Code and Cursor are basically just issue trackers and some examples. I'm actually surprised they have as many stars as they do.

neuronexmachina··on Ask HN: Why do Cursor, Windsurf and Claude Code dominate the conversation?
Yup. Claude Code's repo is basically just an issue tracker.
neuronexmachina··on Coding with LLMs in the summer of 2025 – an update
In my experience, devs generally aren't secretive about tools they find useful.
neuronexmachina··on Basically Everyone Should Be Avoiding Docker
Almost literally so with his "Boomer Rants in Woods" series.
neuronexmachina··on Basically Everyone Should Be Avoiding Docker
It kind of seemed like this might have been the first time the author tried doing anything with Docker containers. And yeah... if you're trying to work with and modify a Docker container the same way you'd work with a VM, you're going to have a bad time.
neuronexmachina··on No One Is in Charge at the US Copyright Office
It's kind of confusing since the LOC serves Congress, but the Librarian of Congress is a President-appointed and Senate-confirmed position. They're supposed to serve for 10-year terms (she was appointed in September 2016) though, and my understanding is it's a open question whether the President can legally fire a LOC before their term is up.

https://www.law.cornell.edu/uscode/text/2/136-1?hl=en-US

neuronexmachina··on A new PNG spec
This would be great for things like exported Mermaid diagrams.
← PreviousPage 5 of 23Next →