3,427 karma · joined September 18, 2016
For me, success means "robust structural intuition". Perhaps frame it as understanding that's robust to adversarial noise? To fuzzing testing? If you fuzz content, changing numbers, inserting negations and lies, how extreme before there's a "wait, that doesn't make sense"?
Merely quantitative isn't sufficient. An Ideal Gas Law chapter problem, with numbers for solid Argon - mindless plug-and-chug - is not this success. But a sense of reasonable values, yes. Contrast the first-tier med student, asked for red blood cell size, who failing to recall it as a factoid, is quantitatively lost, retreating to "really really small".
Similarly, "descriptive" can be deep structure and constraints of a domain, focused on building structural intuition, or at least trying for it, or an embrace of "stamp collecting" focused on regurgitation.
I nod to "foundations for subsequent study, with the intended outcome that students have a broad but shallow understanding of core basic ideas. Lots of biology makes intuitive, mechanistic, and visual sense, much like [...] introductory chemistry. [...] without the broader context the understanding would be relatively fragmented, lacking the big picture." But then contrast it with content presenting a not-broad and quite-shallow take, that pervasively fails to engage with the domain's core structure. And then, even on its own shallow terms, still fails outcome-wise: First-tier institution students, coming to intro genetics from intro bio, lacking even a firm grasp of central dogma? Stoichiometry students not even thinking of atoms as real physical objects? So I see "wonderful books" and think "wat?!? - how about profoundly and pervasively dysfunctionally unhelpful books?".
Perhaps at root, there might be different visions of what a "big picture map" best looks like??? Maybe picture a human surface map, vs a USGS topography and geology one. Do details clarify by exposing patterns, or obscure as clutter? Does underlying structure? Do year-to-year research insights provide opportunity and motivation for frequent rewrites, or is there relative stability and slow evolution? Are labels and vocabulary treated as foundational, or as relatively unimportant? If you haven't seen part of the map, how important is being able to sketch it in plausibly? If fragmented into puzzle pieces, how important is being able to fit them together? How important is seeing why things are the way they are?
Maybe the contrast between a slim tourist guidebook, versus walking in conversation with someone who deeply understands the history and society and structure of a city? Both are accessible experiences. Conversation that's numerate will be richer than non. But while the guidebook can provide a bit of orientation, it's not even trying to leave you insightful and deeply clued in.
Thanks again. I'd not thought of the fuzzing analogy before.
Curious how perspectives vary. I would have said there's basically nothing available, textbooks being horribly wretched.
I don't know of anything which takes a "bottom up", rough quantitative, engineering first-principles intro to cell bio, let alone to biology. No whys and hows of building close to thermal noise energy levels. No focus on pervasive multi-scale cross-cutting strategies for localization and compartmentalization. No energy budgets, not feel for reasonable numbers, no... sigh. When you see a nifty foundational insight mentioned in passing in a research talk, it's a really good bet it won't be in textbooks any year soon. One of the causal threads leading up to TFA, the Harvard bionumbers database, was born out of someone's 'it's absurdly hard to find numbers'.
Chatting with a cell bio tome publisher years ago, about what absurdly implausible resources would be needed to do something transformatively better, the snark for "but it has 100 authors!" was "nifty - and how many for the second page?". Maybe now with AI we can start nibbling away at this faster.
For illustration, consider the classic animation of a walking kinesin towing a vesicle. One could jiggle-ify it. But that won't convey that during every step, the vesicle has done a "balloon in a hurricane" exploration of every possible position it can reach while remaining tethered. Won't clarify that the very very misleading "I'm just a peaceful barge" vibe is entirely animation fantasy. Secondary content could have been added to defuse this negative educational impact, but the choice was made to optimize for, and I'm quoting, "pretty".
Jiggle-ification takes perhaps the biggest educational downside of these animations, and makes it even more misleading.
[1] https://commons.wikimedia.org/wiki/File:E._coli_Bacteria_(73...
There's a searchable database of bionumbers[1], and a draft version of "by the Numbers" officially online[2].
[1] https://bionumbers.hms.harvard.edu/search.aspx [2] https://www.dropbox.com/s/gvpleqtcv8scro4/cellBiologyByTheNu...
In case anyone else wondered about using gptel to edit thinking (eg vis Qwen3.6's `preserve thinking`), [1] explains:
> In a multi-turn request, from the time you run `gptel-send`, everything the LLM sends is passed back to it [...during tool calls...] includes multiple reasoning blocks. [...But...] subsequent gptel-send calls read their input from the buffer contents (or active region, etc), so the reasoning blocks in the buffer will not [] be sent as "reasoning_content".
But in org mode, those are apparently `#+being_reasoning` blocks (`gptel-include-reasoning`?), so editable thought might be an easy addition?
A caution, fwiw, that any llms which respond with interleaved content and reasoning blocks, currently only work when not streaming, and fixing that is non-trivial.[also 1]
The data remains available. It was a TidyTuesday ("social data project") for 2025-07-08.[4] This response[5] looked at TFA. (This week's TT is ag tariffs.[9])
I just did a quick and sloppy search, so there's likely more out there. Curiously, I found AIMode and Bing/chat less immediately helpful than I'd have guessed.
Years ago I used the xkcd data for a prototype web interactive for kids, which shader filtered video to selected colors... but it was overlapping rather than a partition, and I'd never leave out cyan. Hmm, maybe a vibe coding target.
[1] https://blog.xkcd.com/2010/05/03/color-survey-results/ [2] https://www.datapointed.net/2010/06/xkcd-color-name-strata/ [3] https://luminoso.com/the-color-cloud-an-interactive-visualiz... [4] https://github.com/rfordatascience/tidytuesday/blob/main/dat... [5] https://jofrhwld.github.io/blog/posts/2025/07/2025-07-09_col... Off topic: [9] https://github.com/rfordatascience/tidytuesday/blob/main/dat...
This worries me about how we approach teaching rough-quantitative reasoning. It's widely thought of great importance for expertise. But even when there seems outlier opportunity (a first-tier institution emphasizing teaching, a dedicated class, for non-freshman, in physics), the questions... "Calculate how long to cook a turkey for, without reading the label or googling?" Really? Getting to a clear payoff may require a broader scope, or a different emphasis, or a reimagining.
> isn't any meaningful use of this step until it's combined with others
A kindergarten science educator suggests their students have a human right to understand their physical world then, not a lifetime (for them) later. Intriguing to think what that might look like as a goal... at any level.
Science education research, like teachers, is focused on the possible. Existing students, with existing resources, and constraints, and objective metrics. There's little incentive to stack counterfactuals: what if my incoming students had been taught A successfully, and B and C successfully, then done together, they enable D, and oh wow. Not when we're struggling to manage even one with any consistency. Disaster-triage chain-of-care doesn't encourage funding of population heath research. Especially when the possibility space is so little explored, that we don't even have a vision of what an E and F might look like. A incentive bootstrap challenge.
There's a meme, "Why develop one's own expertise? It's a poor investment. When you need it, you can hire it." Does AI make us all trust-fund kids?
An intro-physics educator at a first-tier university, observes that their entering students, having attended such well-funded schools, with such highly-skilled teachers, presenting material so clearly... widely lack both the skills and inclination to wrestle with a body of knowledge to extract their own understanding. To the detriment of their early-college education. The sci-ed snark version is, raising all students to the level of these, would be both an unimaginably immense triumph, and an ongoing profound failing to teach well. Will AI give everyone material presented so clearly?
More rough-quantitative reasoning? Fermi questions. Especially if done by collaborative iterative bounding "Who can suggest another soft/hard upper/lower bound? ... What do you think of that argument?"
In contrast to a plug-and-chug theme, illustrated by an ideal gas law problem in a popular textbook, which despite years of use, and qc passes for multiple editions, has numbers for solid Argon. Reality checking, a feel for reasonable values, a "Is this approximation plausible here?", being pervasively "not on the exam".
[1] Qwen3.6-27B: Flagship-Level Coding in a 27B Dense Model https://news.ycombinator.com/item?id=47863217
Fwiw, I was playing with an "outliner"-tool collapse/expand idiom, on synthetic literate-programming markdown files, with #ids on headers and blocks. Insufficient experience to suggest it works, but it wasn't obviously not working, and that with a non-frontier model and very little guidance. Other familiar related idioms include <details>/<summary>, hierarchical breadcrumbs, and plan9-ish synthetic filesystems `foo.c/f.{c,dataflow,etc}`. One open question was comfort with more complex visibility transformations or sets - "hide #bar; show 2 levels of headers-only under #hee; ...". Another was cleanup - recognition of "I no longer need this and that".
I suggest one source of the comment's downvotes, was not the views expressed, by the style of argumentation used. Though priors which read in a different subculture as not merely incorrect but silly, I agree didn't help. I'll focus on the argumentation.
Though as an aside, one difficulty in communicating between bubbles, is recognizing that "everyone knows" can become "that's absurd" at bubble boundaries. This can be funny. When Hollywood folks were complaining (re copyright law), on the record, about congressmen not "staying bought", rather than admitting to bribery, it was perhaps more something vaguely like "Everyone I talk with about this topic knows we're right.[bubble] Obviously and completely right. He knew what's right, so we funded him. Since he knows what's right, and did something else, the only thing which makes sense, is he was bought off to do what's not right". To do a cartoonish characterization. Anyway...
Yesterday, exploring your previous comment, I removed the link, and fed it to... either Bing/chat or ggl AIMode, prefaced with something vaguely like "The person who wrote the following wishes to escape their thought bubble. Evaluate and make suggestions to help them. "...comment..."". Thinking it might help me reply with something useful. The result was long and interesting somewhat (so probably bing). Maybe one-shot LLM chats could be a tool towards a goal of bubble busting.
The item I recall now, was noting a "morality play" style of argument, with cartoon characters ("liberals" this, "scientists" that). Imagine in some profession context, you're looking for someone to provide reasoned technical analysis of some complex system, and you get "oh, it's straight forward - <large group> just needs to confess their sins". I won't here critique that as theology, but as analysis, what would think of that? What value would you place on it? Or in a discussion of some web phenomenon, a comment "it's simple - web devs are bozos - they just need to pay attention". There is a, lack of fruitfulness, in this flavor of abstraction. So I suggest "dissenting opinion on this liberal site" misses one likely source of the comment's downvotes.
Thanks for the conversation.
[1] The acyclic e-graph: Cranelift's mid-end optimizer https://news.ycombinator.com/item?id=47717192
> It is 12:56am. Do you still want to be on the internet? Yes No
Lol. Nice touch.
> No -> "Okay", fade to black.
Consider a South American fishing village culture, which didn't do concepts of "shit happens", nor "unintended consequences", nor "systems failure". So everything that goes wrong, is the result of some one individual's intent, exercised by direct action or by supernatural whammy. Your neighbor. Your family. Your enemy. Some fish escape the group net? Gather around to figure out who did it. Your plant not growing well? Stub your toe? Pay the witch doctor to tell you who whammied it/you, and to whammy them back. Described as a singularly toxic interpersonal environment.
Now moving subcultures to a safety/learning/challenge culture is so very hard (aviation CRM, etc), perhaps it's a valid approximation to view its absence as fixed. But having just read a comment suggesting unaddressed climate change should be blamed on the science community because reasons, I'm sensitized just now to "our local cultural dysfunction is simply human nature - it's them that's the problem". Even acknowledging bad actors fueling the dysfunction in which they thrive.
An interactive microscope of regolith.[2] Like tiny broken glass, hard as rock, and sticking to everything like static-charged packing peanuts.
An old tech memo and paper.[3][4]
[1] https://an.rsl.wustl.edu/apollo/data/A17/resources/a17-techd... page "27-28" 258, 50 in pdf. Lots of other mentions of dust. [2] interactive microscope of regolith https://virtualmicroscope.org/sites/default/files/html5Asset... [3] The Effects of Lunar Dust on EVA Systems During the Apollo Missions https://ntrs.nasa.gov/api/citations/20050160460/downloads/20... [4] IMPACT OF DUST ON LUNAR EXPLORATION https://adsabs.harvard.edu/pdf/2007ESASP.643..239S
Or, you might save token sampling telemetry (perplexity, etc) alongside a CoT and result. So when read, it's like a captured performance - this sentence smells "hesitant", that one "confused". Poetry vs prose. Or, a consistentcy checker might add smells of "something's not right here". Or... emojis that emote.
For a dog, that's not merely a lamppost, it's richly-evocotive local history. To a dev long experienced with some codebase, that's not merely a filename, it's that nasty file that bites.
One open question is whether you can find and calibrate embeddings to provide an informative whiff, without badly degrading reasoning. And be cautious of, and suspicious of changes to, a scary file, without becoming too avoidant. Also, salience bias. Also, imagine debugging scent hallucinations.
Activation-rich text - auxiliary non-linguistic embeddings as meta-signals... the random silliness local LLMs encourage.
As a tradeoff example, yesterday I again tripped on the KISS "CDATA doesn't support HEREDOC-like prefix whitespace removal". So does one indent, compromising payloads where leading ws is significant, or not, confusing humans and llms.
Re reinvention and first principles, aside from engineering tradeoffs, it can be hard to understand design spaces and to be aware of related work. I suspect there's a missing literature to support these, but professional organizations have been AWOL, and research funding dysfunctional. And commercial conflicts of interest. And it's hard. But now coding LLMs are messing with "don't reinvent wheels" payoff tables. Perhaps we'll someday be able to be explicit about design space structure and design choice consequences too. And perhaps we're already getting transformatively more flexible around format extension and interoperation. TFA isn't just a new format - it's a github repo which will help teach LLMs how to do progressive execution of fenced code blocks, making the next format which does this potentially easier to create. "Merge in what X does, but <change request>". Yay?
IIUC, non-meme carcinization is something vaguely like "similar tradeoffs pressure towards similar forms in diverse contexts". LLMs might help us more easily understand tradeoffs, implement forms, and manage diversity?
So many formats, with different tradeoffs around readable/parsable/comments/etc. I wish there was a "universal" converter. With LLM's sometimes used to edit chat traces, I'd like ingestion from md/yaml, not merely a "render from message json".
So .json `[{"role": "user", "content": "Hi"}` <-> .md ` ```json\n[{"role": "user", "content": "Hi"}` <-> above ` ```user\nHi` <-> `# User\nHi` <-> ` ```chatML\n<|user|>\nHi` <-> .html rendered .md, but with elements like <think> and <file> escaped... etc.
Perhaps "WWW SPA document"? Using markdown with highly-progressive fenced blocks?
Hypertext (one word, coined 1960s) is quite a broad category. Subcategory "WWW" could fit, as TFA seems WWW-ish. A markdown document format, and progressive rendering of tags and code, seems HTML-like. Though with greater progressiveness - code blocks with streamed execution rather than merely compilation. The progressive JSON callbacks, React, integrated client and server code execution, and server-side rendering, seem closer to WWW SPA than to HTML. Though SPA files often seem more "source" than "document". And the multiple-page "App"-ness of SPA doesn't fit well. SPA seems a better fit than "full-stack". Perhaps some name analogous to "isomorphic javascript"...?