mfld

Based on those meeting notes, the conflict of interest that arises when attempting to add features that compete with paid ones is real. So its that ideology that it is actually needed for a Government user/contributor.

While there's vscode console, I think that bare Xterm.js would be a nice addition to the list.

Agreed. Proprietary tools could then rely on those coreutils without any license fears.

Nice - thanks! I assume the non-naive implementations skip the sorting and instead hash the input lines?

The NHGRI updated these plots for years. Sad to see that there is no update since 2022, presumably due to lack of funding.

The sub-$100 genomes could be in reach within the next 5 years, from what I have seen.

I like puzzles. Therefore I'll give a shot what this might be: Lovable for apps.

I can relate. I recently used ChatGPT/DallE to create several images for birthday coupons for my daughter - a.k.a. girl in different activities. She likes Mangas, so this was the intended styling. 3/4 of the time was spent working around diverse content policies.

Thanks! So the --long essentially signals the decoder "I am willing to accept the potentially large memory requirements implied by the given window size"

    Using larger-than-default window sizes has the drawback of requiring that the same --long=xx argument be passed during decompression reducing compatibility somewhat.

Interesting. Any idea why this can't be stored in the metadata of the compressed file?

No chemist, but the outcome - a cellulose film - seems to be about the same even though the production process is different.

I assume most protests are driven by a Not In My Backyard attitude.

Maybe another application could be the ranking of candidate variants for cancer immunotherapy? As far as I know, lncRNAs are sometimes assessed.

Yes, most bioinformatics tools are the result of research projects.

However, the most common bioinformatics file formats have actually been devised by excellent software engineers (e.g. SAM/BAM, VCF, BED).

I think it is just very convenient to have text-based formats as you don't need any special libraries to read/modify the files and can reach for basic Unix text-processing tools instead. Such modifications are often needed in a research context.

Also, space-efficient file formats (e.g. CRAM) are often within reach once disk space becomes a pressing issue. Now you only need to convince the team to use them. :)

Unfortunately the line between 2 and 3 is very blurry. Like paper mill output submitted to legimate medium-to-low impact journals. Some of it gets inevitably published, others just puts a strain on peer reviewers.

An alternative for the use case of spawning dev environments would be https://github.com/pvolok/mprocs

I have no 23&Me profile, and I prefer to keep my genome private. However, IF you are NOT in the personal-data risk-averse camp, there is a point in rather giving your genome data than giving your online activity profiles. The former can at least be used for biology research/treatment development and thus clearly has higher upside for humanity.

I generally enjoyed the article. Maybe it's because the classical functional categorization/cataloging approaches in molecular biology are rarely sufficient to explain experimental data unless you are an expert and know all the exceptions and special cases. So the Predictive Biology approach seems a promising path, particularly since a lot of data for ML training is available.

That said, the formulation "machine learning is the native language of biology" seems odd.

I agree with the low demand for more expensive personal WGS. I think you can mostly get what you want with ySeq: currently 400$ for 90 GigaBases WGS sequencing, with the data sent to you via SD card. You can request immediate data deletion. Only genealogical analysis is included, everything else is DIY.

I wonder if letting guinea pigs listen to Adele's 'I Miss You' at 102 dB for long periods required approval from an ethics council.

I find that the Airbnb fees are too high for what you get, which often boils down to the contact information of the renter. For some regions in Europe, I actually prefer again local vacation rental agencies, which have similar fees but much more service. Of course, their websites are often not great, but describing your requirements via phone or email gives great options.

Related discussion from 2 months ago: https://news.ycombinator.com/item?id=43403821

I find that Claude code works well to fix rust compile errors in most cases. Interestingly, the paper didn't compare against agentic coding tools at all, which of course will be more easy to use and more generally applicable.

Another irony is that the biggest (business) beneficiaries of applied DMA would be other US-based digital services companies like Netflix or Epic.

Can Navidrome/Jellyfish integrate with Sonos? For me, the Sonos app still is not able to reliably index/play music from a network share.

Nice - I feel this introductory guide fills a gap. Also, I really like his video tutorials.

That is what I was wondering as well. Where can I find investors willing to invest up to $1M with an expected 2-3x ROI on typical VC terms? In particular, for pre-revenue ventures. And how can you keep that 90%+ equity with 10 angel investors?

Did you find differences in performance or reliability of the S3 and Kubernetes services already?

> well, it's always in dark mode

So it's no TUI app that can accommodate changes to the terminal emulators color profile? I am a bit disappointed.

We chose GCP, and the work to accommodate restructuring of services (currently container registry to artifacts) is indeed an annoying.

Agreed. Or number of installations, if that is tracked.