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levocardia

2,663 karma · joined February 13, 2024

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levocardia··on Clinical failure rates over the decades: yikes
I'm actually surprised it isn't going up over time. That is naively what you would expect as the low-hanging fruit is plucked. So the fact that it's been stable is probably a sign that scientific advances are roughly keeping pace with the (presumably) increasing challenge of finding ever more targets for drugs.
levocardia··on Alphabet's cash burn raises alarm for Big Tech as AI spending climbs
So you're short the market, right?
levocardia··on The Kimi K3 Moment
Indeed, the B2B / no-data-retention market is still going to provide plenty of business for American companies even if every hobbyist uses open-weight models.
levocardia··on Schema Harness Achieves ~99% on Arc‑AGI‑3 Public
(1) What does it score on the private test set? (2) Does this approach generalize to, e.g., Atari or NES games, or is it just hard-coding priors about the games into the model (as Chollet specifically warned was a chronic problem in benchmarks in the original Arc-AGI paper)
levocardia··on The Annotated JEPA
100% AI-generated. Yawn.
levocardia··on Life with Hazard Ratios
This is missing the most important thing which is why HRs are so damn useful. It's because (a) survival analysis is very statistically powerful, but (b) many survival curves do not follow a very well-described parametric function. The genius of David Cox was in realizing that, when proportional hazards hold, you can just cancel out the unknown survival function and get the multiplicative hazard ratio immediately, in a statistically powerful and statistically efficient manner. Extremely useful if you are, say, trialing a novel chemotherapy drug and want to end your trial ASAP to get everyone on the intervention arm if the drug actually works.

The places where proportional hazards gets squirrely (very long observation times, crossing curves) are a small fraction of the use cases of survival analysis, and dunking on them for "not being Bayesian" or whatever misses this broader context.

levocardia··on Grok 4.5
I think the "secret sauce" is not juicing the benchmarks. Claude models just feel like they are better than the benchmarks suggest, in terms of smarts and creativity, while models from every other company feel worse relative to what you'd think from the benchmarks. Only company to really internalize Goodhart's Law, IMO.
levocardia··on Every new car sold in the European Union must include a driver monitoring camera
Cash for Clunkers was not mandatory
levocardia··on Costco is the anti-Amazon
Also this argument is easily refuted by the US Postal Service, which physically delivers individual pieces of paper in a few days, for pennies.
levocardia··on Weave Robotics launches Isaac 1, a $7,999 home robot with Fall 2026 deliveries
I was actually waiting for it to pull out a butcher knife and reveal the landing page is actually a promo for a techno-horror film.
levocardia··on Weave Robotics launches Isaac 1, a $7,999 home robot with Fall 2026 deliveries
Real answer: how many animals can you think of with three legs?
levocardia··on Weave Robotics launches Isaac 1, a $7,999 home robot with Fall 2026 deliveries
I have a startup idea: I will make the robot that ferries your laundry robot up and down the stairs.
levocardia··on Department of Commerce has lifted export controls on Claude Fable 5 and Mythos 5
3.5 days to escape the permanent underclass ;_;
levocardia··on Department of Commerce has lifted export controls on Claude Fable 5 and Mythos 5
I'll take the opposite side of that bet. My prediction is that Fable 5 Re-Release will have safety classifiers that flag much more often on mundane front-end and back-end coding tasks.
levocardia··on Nano Banana 2 Lite
I sense a business opportunity: a web app that de-sloppifies real estate, airbnb, and vrbo photos! See what it really looks like, thanks to the power of AI!
levocardia··on Why Won't Europe Build AI Data Centers in Iceland?
This article is 100% AI generated slop
levocardia··on Professor denounces mass AI fraud on an exam at Brown
The craziest part is that a game theory expert can't see the problem here!
levocardia··on Historical memory prices 1960-2026
Yes, you really need "dollars per amount of RAM you need for standard computing tasks." Windows 11 requires a bare minimum of 4 GB of RAM, Window 10 only needed 1 GB.
levocardia··on Too many R packages: CRAN is inundated with submissions
"The real problem with this package is that it makes things easy, instead of hard"
levocardia··on Plotnine
|> works too
levocardia··on U.S. science is in chaos
...which is why there are no emerging far-right-populist political movements in welfare-heavy societies like the UK, France, and Germany, right?
levocardia··on Has AI already killed self-help nonfiction books?
Conversely: the self-help nonfiction book existed because it was the only practical way to monetize "good advice" or "good ideas" at scale. Now you can do a podcast or a youtube series and try to make money from advertising/affiliates/etc, but for a very long time, "buy my book" was the only game in town
levocardia··on Confidential submission of draft S-1 to the SEC
So are you short the market?
levocardia··on How to convert between wealth and income tax
There is a footnote discussing this point; he uses 5% as the risk-free rate.
levocardia··on Pope Leo XIV’s first encyclical Magnifica humanitas to be published May 25
The intentional parallels are hard to miss:

- Pope Leo XIII wrote Rerum Novarum; current Pope Leo XIV chose his name as an explicit gesture to his nominative predecessor

- This encyclical is a return to the earlier tradition of latin names (Magnifica Humanitas) for encyclicals, as opposed to many of Pope Francis' which used Italian (Laudato si')

- The official date it was signed was 135 years to the day since Rerum Novarum

- The Pope is personally appearing and speaking at the presentation; usually these encyclicals are just released at a small press conference without the Pope himself being there

Rerum Novarum intentionally tracked a third path, rejecting both socialism and laissez faire capitalism at the end of the 19th century. Gesturing so overtly towards it suggests that this new encyclical will also try to establish a "third way," grounded (as the title suggests) in human dignity.

Leo XIV has not published any encyclicals yet; this will be his first, and an extremely ambitious one at that. I also am very eager to read it.

levocardia··on The AI zombification of universities
>As it turned out, the online version of MIT is not a substitute for the actual thing.

More precisely, the people motivated enough to actually do the online MIT version were often already on a high-performance trajectory, and for the people who were not, few people took the online credential seriously, despite whatever skills they acquired.

levocardia··on Princeton mandates proctoring for in-person exams, upending 133 year precedent
Not even prestigious ones. The school needs to sound like it has strong penalties against cheating, so there are really strict-sounding policies ("zero in the course"). But also, so many students cheat that actually enforcing these policies uniformly would hurt your graduation stats, make unhappy customers (students + parents), and hurt your revenue if you actually expel them. So the equilibrium is that the burden of reporting cheating is foisted upon professors, and it is understood -- though never explicitly communicated -- that academic integrity proceedings will be a huge administrative pain for you, the professor, and it is in your interest not to initiate them.

The outcome is predictable: unless there is a scandal of massive proportions, the issues just..."go away" on their own. With some discretion for the professor to either just look the other way, or ding the student enough to feel vindicated, but not so much as to actually hurt the university's interests.

levocardia··on YC's Biggest Scandals
Probably the worry that the jump from "we defend against slaughterbots" to "we built a better slaughterbot" is just around the corner
levocardia··on Pulitzer Prize Winners 2026
Who do you think would be deserving of an outside-the-window Pulitzer?
levocardia··on US healthcare marketplaces shared citizenship and race data with ad tech giants
The actual "sharing" was using the Meta pixel and TikTok's equivalent, presumably so the healthcare exchanges could do retargeting or similarity-based marketing to get people to sign up for health care coverage. Which, narrowly, seems like a reasonable thing to do. But of course using the pixel automatically "shares" the data with Meta/ByteDance/whoever, and they get to use it for whatever nefarious purpose they want.
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