jcrubino

Then don't settle for any advice who can tell you to pop a pill.

The problem is even for hydroxychloroquine the most at risk patients for serious COVID-19 illness (People with Diabetes and Heart issues) are under the well established precautions in using the hydroxychloroquine. To build publics faith in the idea that one medication is going to really come through is haphazard at best.

Non Invasive Ventilation is the preferred mode to assistant patients with the lung pathology COVID creates. This requires higher than normal lung pressures for oxygenation as the concentration of O2 can be detrimental to the lungs causing a worsening. The extra pressure means a lower concentration of O2 is needed to help the patient.

Intubation adds more risk to the patients lungs recovering because the volumes of air moved in an out can also cause injury; as the lungs are no longer moving as well with the increased fluid COVID patients experience. A full featured ventilator is not a silver bullet, it is a sign that things are very serious for the patients lungs. The shorter amount of time on the ventilator the better, which also means no ventilator unless absolutely necessary.

Using a mask like this does the basics, but we do have to rely on the patient to move their own air volumes in and out. Often they are able to do this, so this mask could provide real benefits.

The bubble helmets you can see in Italian hospital footage have been shown in an 2016 study to reduce the need to intubate and put patients on a full featured ventilator. The caveat being the COVID pandemic experience will glean a lot more insight into keeping patients from being intubated and off of full featured ventilators.

It is a ventilator in terms of displacing exhaled CO2 via the volume of air moving through the circuit, mask and lungs. It also provides positive pressure to aid in more effective oxygenation.

There is alot of selective focus and attention to "ventilators" currently. The danger is people believe that a fuller featured ventilator will save them when in reality (it will in some cases) public health focus should (arguably is) be on everything that can be done to keep COVID patients from being intubated and needing a full featured ventilators.

There is a risk that we run out of ventilators because they are dedicated to long term life support of patients that become dependent on them when they could be providing the short term ventilatory support of patients who will recover enough not need one. This is another scenario given our medical capabilities, well trained healthcare workers, and cultural outlook we are not yet talking about.

There is no problem with cpap. Filters are available for the machines and tubes that lead to and away from the facemask.

CPAP is a good start for any patient that has a spontaneous inspirtory drive and acceptable work of breathing.

The problem for the COVID patients is more so oxygenation then ventilation (this is a technical complication of the disease were studies have shown that focusing on O2 with an elevated CO2 is better in the long run then trying to ventilate the lung to normal CO2 levels as the volume of air needed to do this effectively can do more damage to the lung).

CPAP helps O2 absorbtion in the lungs by maintaining a generally elevated pressure that pushes O2 into the alveolar sacs for perfusion without requiring a concentration of O2 that might create a fibrotic lung.

If the patient passes a certain threshold of respiratory distress and work of breathing they will need to be intubated to carry on the same O2/Co2 strategy above to protect the lung from further damage.

After intubation is when a real ventilator will be needed. Ventilators can be very simple so long as people are aware the patient will be out like fashion so the ventilator can do its thing and medical staff monitor the patients vital systems. This is not always ideal as voluntary spontaneous movement of the patient can help relieve some of the neuro and physiological lung issues they are experiencing.

Ideally everything done for the patient as soon as they hit the ward is to keep them off a ventilator for their own and others best outcomes.

You forgot the Respiratory Therapists.

As a former respiratory therapist I understand you concern about a project like this. I doubt anything beyond a CPAP machine is helpful for home care without risking a ventilator lung injury which is often characterized as the same lung pathology that COVID-19 creates in the acute respiratory cases.

That said, at home you could help at home patients relieve some symptoms until proper medical attention is available by doing positive breath holding exercises and chest percussion therapy to recruit more alveolar activity.

Paging Dr. Scott Weingart

https://emcrit.org/emcrit/some-additional-covid-airway-manag...

Get US grown citrus trees (foreign food is irradiated and seeds become non-viable)... eat them... save the seeds... germinate ... you will have more than enough plants to get it wrong and right with! All you need is some potting mix and solo cups with a hole or two for drainage to start.

Taking care of plants. The first thing my niece (3) and nephew (5) do when they get in the house is check what plants need to be watered by sticking their hands in the potting soil. The plants and taking care of them has achieved peak interest for a few months. Two caveats, 1) they do not live with the plants 2) It is a ploy to get the water spraying can out. They also equate it with working somewhat as a few rules have to be abided by - wear shoes because the citrus plants have thorns that fall on the floor. The floor has to be swept... etc. The concept of state phase changes of water was introduced to the newphew this weekend as there is snow outside where we live. We got to the idea that if he knows the right numbers he can add together how much heat is needed to melt the snow. This is all at the 5 year old level but the conversation got there.

Brad I have learned much from your Go presentations and learning about your path to becoming a Googler. Thanks!

... But if you are responsible for today's downage just say it. : )

Did Dr. Knuth stopped giving the Christmas Tree lecture this last year?

Is the Fridman interview the replacement?

Is that (this akin to) what Paypal did in the early days with their money market accounts?

Thank you for responding. I have been very curious on whether Rusts are active in salmon. I was not serious about zombie salmon though. One salmon is a rather small sample size regardless of the common sense reasoning around the subject at hand.

Have you ruled out zombie salmon... or salmon with commensal micro-biological activity such as a rust?

A terrible experience for you, but our business model was validated as demand has been above capacity for years! Take that SI valley. La baleine échouée est maintenant la nôtre!

The joke going around is: Is that a climate catastrophe or taxable waterfront property?

Absolutely correct. Performance took a big hit in python 3 as well.

If users are performance bound through use-case, chances are they are using pypy. If pypy3 is going to lag python3.6 + why upgrade at all. Pypy just got numpy and pandas.

My sense is that Python 3 was redesigned with web-services in mind like Youtube, when the highest code contributing use-case in python was science and data pipeline related. The science users are all still using python, but only in ways that Python 3 enhancements were not especially important for.

True, I am not trying to provide the exact definitions for what qualifies as a PG or YC startup per se. But I believe you can quote PG as saying the "ideal exit" for any startup YC incubates is a public offering. Additionally the idea of "lifestyle" startups is well known in SV and the concept is also well known to be frowned upon by the VC's who make the most noise who are looking for a big exit one way or the other.

They hedge your risk of time and effort by giving you resources of capital, networks, IP to make things happen plus a bonus if the startup gets traction enough for a public offering or profitable exit sale. There are many devils in the details but getting paid to do something you are committed to completing is not a bad offer.

PG context of a startup is a company that has the potential to make it into a leading stock market index. Anything else is considered a "life style" business and not within YC or most other VC's scope of interest for funding.

AKA: Nothing new yet (for web).

From the time of the telegraph traders and markets have always been trying to get an speed edge. This has never stopped and likely never will. The meaning of HFT changes with the times.

Handling tick data even could help and be helped in the case you outlines above.

"Ela runs on .NET and Mono and supports Windows, Linux, Mac OS and many other environments"

http://elalang.net/about.aspx

Scala, Go and Erlang are all shown to be comparatively high in concurrency errors... so this may only show languages with a concurrency focus find the concurrency errors early and often.

And the authors at least noted that "The enrichment of race condition errors in Go is likely because the Go is distributed with a race-detection tool that may advantage Go developers in detecting races"

They are a tight lipped bunch.

I recently asked the Chinese language forum on Bitcointalk.org about their use of trade platforms and bots and the people in the forum seem very skeptical of bitcoin trading in general especially at Chinese exchanges. I found this to be quite a surprise given the Chinese markets own bitcoin trading volume. The Chinese exchanges themselves report that their mobile platforms are very popular which is even more of a surprise.

I think algo trading in Bitcoin is a hobby for most and very few take it seriously beyond writing or customizing their own platform.

However there are more brokerage services opening to provide liquidity and trade impact minimization for professional financial services.

The biggest algo traders might be the Chinese exchanges themselves to support zero cost transactions.

I think the devs have been clear on no need for generics anytime soon. If they do anything like generics its going to be structures and patterns for concurrency related development.

Anyone want to discuss competitive sober strategies for startups?

I see four main issues that the money is being used for

1. Location

2. Business Scaling

3. Work-Place Incentives

4. Founders Optimistic Self Valuation

These issues are all necessary to a high degree but what viable options are there that give startups a competitive environment to offer and work with?

Have those guys sign up for Y Combinator!!

Shen and Qi are written by an academic. More likely than trying to sell the book is the that author is trying to ensure that the core theories that got put into the languages stay in the language with out alterations to the core principles... what exactly those are I never delved into enough for comment but the documents and history point to a very principled author and language being created.

U Mich. Prof Scott E. Page http://masi.cscs.lsa.umich.edu/~spage/