jcrben

"Can't do arithmetic, that's for beancounters"

Good point. I think you can get them embedded in consumer devices for pretty cheap lately; I bought the Dylos about a decade ago.

A warning: the cheap air monitors don't monitor particle count, just CO2. If you're allergic to pollen you expose yourself to it by opening windows. I've had to help a couple friends who used this and ended up sneezing and sniffling like crazy.

I have the Dylos monitor which does monitor particle count so you can see it drop when your air filter is working https://www.amazon.com/dp/B08F2YM8SM/ref=cm_sw_r_apan_glt_i_...

Humidity kicks dust mites into hyper breeding mode, so not great if you have a dust mite allergy. I like to keep my home dry.

I've had this before from dust mites. I was able to eliminate them from my small apartment with a dehumidifier and freezing my bedding plus occasional Claritin (loratadine), but immunotherapy is the ultimate way to address allergies.

There's even a yc startup doing immunotherapy these days wyndly https://news.ycombinator.com/item?id=26227807

I agree with Elon Musk that immortality is actually not great, and would instead lead to a static dystopia. New generations need a chance to put their own stamp on the world.

If someone published a promising in vitro study, the mere fact that it was done and even the barest hint of a conclusion can dramatically impact one's decision to pursue that line of research. So I'm a bit skeptical that there's negligible value in biomedical research papers.

Miners suck money away from real batteries who would otherwise be smoothing out the peaks. It's not good for efficiency or climate change.

People point to miners using up excessive hydro or geothermal capacity (Quebec and Iceland), but these areas were prior doing low-carbon factory work such as aluminum manufacturing.

> You can't just do the same strategy as someone else and expect to get ahead. You gotta place your bets on a different strategy.

No, you don't. Betting all on black is just a different gamble, and in my opinion a more risky one. But investors are ok with it because many prefer pure play gambles.

There's no law of nature saying that you have to zig when others zag. A big opportunity like clean energy has room for many winners.

I agree w/ you, but I'll also add that the premise that the evidence on diet is equivocal is pretty offbase. The evidence for EEN is pretty robust and held up over a couple dozen studies - see my other comment https://news.ycombinator.com/item?id=29453808#29456208

The idea that diet doesn't affect the disease is incorrect. We've known for a while (40 years now?) that exclusive enteral nutrition has an effect size on Crohn's (seems to be pretty strong) and it's even similar to prednisone in treating flares particularly in children.

https://www.cochrane.org/CD000542/IBD_enteral-nutritional-th...

A couple years ago a trial looked at replicating EEN with solid foods with promising results https://pubmed.ncbi.nlm.nih.gov/30550821/

EEN is a first line therapy in adolescents but rarely mentioned to adults (and in North America less commonly mentioned to adolescents). I was treated at Kaiser and UCSF and nobody ever mentioned it to me. From the Cochrane article: "Whereas 62% of western European gastroenterologists use this therapy routinely for the management of pediatric patients with Crohn’s disease, only 4% of American gastroenterologists regularly use enteral nutrition in their practice (Levine 2003)"

As a Crohn's patient I found it worked well layered on top of a biologic to get into quite deep remission.

Aside from EEN, once you are in remission bowel habits are clearly manipulated by diets - being regular is caused by diet/hydration. I have pretty much perfect consistency right now and it's pretty easy for me to change that if I switch up my routine.

I think it helped a lot and I did a bit of a mini crossover trial where I did the enteral nutrition for a few weeks and then not.

And yeah the elemental formula I tried is https://www.integrativepro.com/products/physicians-elemental... but it's super expensive, tastes terrible, and studies don't show that it has better results than polymeric formula.

Ultimately ideally you only go through the bad phase once. If you can get into remission earlier you have a better chance of durable deep remission where your gut is totally repaired and your chance of the negative flywheel of wound -> bacteria leaking into bloodstream -> tnf inflammation -> bigger wound is minimal.

I used Ensure Plus chocolate with no added fiber. Regular Ensure in the cans has some prebiotic added fiber which was tough on me

EEN is a well-described and effective therapy for Crohn's. Used less in adults, and much less common in North America for whatever reason (awareness is probably kinda low). The trials establishing it happened back in the 1980s IIRC.

Decreasing microbes is posited as one of the possible mechanisms of action IIRC. See the CD-TREAT diet https://pubmed.ncbi.nlm.nih.gov/30550821/

IIRC studies have generally shown that elemental and polymeric formulas are similarly effective, but I agree that Soylent has some strange stuff that prolly wouldn't agree with me.

I had a good experience with Ensure Plus (chocolate) which was used in a clinical trial or two in Australia (or maybe New Zealand). But I used the one without fiber whereas the one with fiber bothered me.

I got Crohn's about the same age (34).

A couple years later at 36 I'm now on better health than I've ever been. I responded well to a biologic (vedolizumab aka Entyvio). But I also did exclusive enteral nutrition for months concurrently to help push me the edge. These days I eat a lot of sweet potatoes and chicken, with relatively little processed food.

I also feel like theracurmin helps me https://pubmed.ncbi.nlm.nih.gov/32412598/

I think it's intended to push people into the premium version where you can customize your button color

EBITDA is bullshit if depreciation is an expected, significant part of your business. For many vc-backed companies, it isn't, but for any company with major physical capex, it very much is a real expense.

There's also the whole inconsistency with capitalizing software expenses... if you want to be aggressive about accounting, you certainly can.

But of course the biggest part of this story is stock-based comp, which is very much a real expense.

What course?

Looks like no phone was the best for sleep, no surprises there

Depends on your timeframe right? Shorter time periods are a bit more random. But there's also clearly some autocorrelation which makes sense given the inflationary / deflationary expectations at play

Many of these pilots are basically just rich people flying for fun.

Well, this is an another estimate: https://pubs.acs.org/doi/10.1021/acs.est.6b02910

IQ damage of any amount is extremely significant and has subtle effects on society which are difficult to economically quantify, and given that many avgas burners basically do it for fun, seems mostly unjustifiable.

Sources outside the home include avgas which is the largest source for lead in the atmosphere https://www.nbcnews.com/business/business-news/leaded-gas-wa...

Agreed that this is a worthwhile idea

Check out https://theweek.com/articles/953819/democrats-getoutofmanhat...

Needs some organization https://twitter.com/jcrben/status/1433936349891944448

Nichomachean Ethics by Aristotle comes to mind. Everything in moderation

That's an empirical statement without supporting evidence.

For natural gas wells without infrastructure, this is a great alternative. It almost certainly makes some uneconomical wells economic. And if bitcoin goes to 200k, you can bet this practice will be booming.

This petrodollar thesis is a stretch. If anything bitcoin increases demand for oil especially due to illicit mining using stolen oil.

We park military in the Middle East mostly due to religious extremist and terrorism risk. Bitcoin does not change that. But even if we park military in the US mostly due to oil, bitcoin doesn't change that either! Bitcoin increases our need for energy.

Nearly 300 hospitalized per day, nearly 500 dead so far. https://www.cnn.com/2021/08/07/health/children-covid-19-prot...

Unknown how many will long-term health effects.

Even seemingly innocuous viruses like Epstein-Barr are tied to various health problems later in life. Why should we knowingly expose an entire generation to a little understood virus?

Creating an agency to flexibly interpret the laws thru regulations is the typical solution for legislative creativity.

I agree to disagree, but I appreciate the measured tone and willingness to engage, which isn't what I've come to expect from from bitcoin advocates.

I'd be happy to chat about it orally sometime; email me at ben@bencreasy.com if you're up for it.

I'll admit that growth, especially absent pollution pricing, is often negative for the environment. But unchecked population growth without tech-driven economic growth isn't great either, as one can see from numerous countries. To win in the marketplace, one often has to do things cheaper. Excessive profits or inefficient processes are more burdensome for the environment. It shows up in mansions, jetsetting around the world, etc. Investment in new ventures attacks this problem.

Investment funds innovation and meets real needs. Inflation which forces people to invest is good. India is country where the people are heavily overweight gold instead of real investing. I believe it has reduced their national prosperity, in the same way bitcoin will reduce global prosperity.