39 karma · joined May 30, 2016
"Tumor-Specific Accumulation Mechanism
E. americana selectively accumulates in tumor tissues with zero colonization in normal organs. This remarkable tumor specificity arises from multiple synergistic mechanisms:
Hypoxic Environment: The characteristic hypoxia of tumor tissues promotes anaerobic bacterial proliferation
Immunosuppressive Environment: CD47 protein expressed by cancer cells creates local immunosuppression, forming a permissive niche for bacterial survival
Abnormal Vascular Structure: Tumor vessels are leaky, facilitating bacterial extravasation
Metabolic Abnormalities: Tumor-specific metabolites support selective bacterial growth
Excellent Safety Profile
Comprehensive safety evaluation revealed that E. americana demonstrates:
Rapid blood clearance (half-life ~1.2 hours, completely undetectable at 24 hours)
Zero bacterial colonization in normal organs including liver, spleen, lung, kidney, and heart
Only transient mild inflammatory responses, normalizing within 72 hours
No chronic toxicity during 60-day extended observation"
Key distinction: Constant and continuous updating. I.e. feedback loops with observation, prediction, action (agency), and once more, observation.
It should have survival and preservation as a fundamental architectural feature.
The weights develop their own inherent logic based on how they relate to each other, analogous to how brain waves encode memory at a level higher than individual neuron networks.
Ultimately, the value of AI lies in the imagination of its wielder. The Unknown Unknowns framework is a useful tool for navigating AI effectively (it powerful to help elaborate on Known Unknowns and identify Unknown Unknowns), along with a healthy dose of critical thinking and understanding how reinforcement learning and RLHF work post-pretraining.
Consider the failure modes of pure algorithmic ranking:
Cold start problem: A phenomenal new restaurant opens. It has no ratings, no historical visit data, no repeat customer signals. Your algorithm buries it. How does it escape this trap? Organic discovery is glacial—it might take months to accumulate enough signals while the business burns cash.
Structural bias: Your algorithm might systematically underweight certain business types. Maybe sit-down restaurants generate longer “time spent” signals than excellent quick-service spots. Maybe your visit detection misses certain building types. The algorithm doesn’t know it’s biased.
Local knowledge asymmetry: The business owner knows their value proposition intimately—they know their recent quality improvements, their new chef, their differentiation. The algorithm is looking backwards at historical data.
Network effects lock-in: Once a place is highly ranked, it gets more visits, more ratings, reinforcing its position. Even if quality declines, the algorithm is slow to react.
Quality-weighted ads let businesses with superior local information challenge the algorithmic ranking. If you’re genuinely better than your algorithmic position suggests, you can bid to prove it. The quality weighting means you only profit if you’re right about your own quality—it’s costly signaling backed by conversion economics. This is “outside-in” because you’re not trying to perfect a centralized algorithm. You’re creating a market mechanism where distributed information surfaces through economic incentives. The businesses that are most undervalued by the algorithm have the strongest incentive to correct it.
Pure algorithmic ranking is central planning. Quality-weighted ads are a market.
Jobs saw something with iAd.
The problem is simple auction mechanics favor whoever has the deepest pockets. A mediocre chain with fat margins outbids an amazing local place, even if the local spot delivers way more value. You’re optimizing for who can pay, not who’s actually good.
To fix this, you weight bids by quality signals like ratings, time spent and repeat visits.
Now ads amplify what’s already great instead of just selling visibility.
Users get better recommendations, good businesses win, and Apple builds trust. That’s how you turn ads from a tax on attention into actual product value—and an improved user experience.