greg5green

> Could You also offer up another TL;DR answer as to why the booster seems to present significantly more side effects?

The first one, some of your cells get told by the mRNA/adenovirus vector (depending on if you had Moderna/Pfizer or J&J/Oxford) to make some 'rona spikes. Your immune system amped up a little bit and your cells feel bad for a bit because of having to spew out spike. Your immune system, which is a little amped up, sees all this and starts to formulate things to kill the spikes (antibodies) and starts to send out other immune cells that clamp down on the cells that are making the spikes.

The second shot? Your cells get the call from the mRNA/adenovirus vector and start spewing out spikes. Your immune system recently saw this so it _really_ starts spewing out more antibodies to get rid of the spikes and more of the other cells to get rid of the spike producers. It it is really ready for the fight and wants to make sure you're ready for the fight in the future too.

The negative side effects are your immune system causing parts of your body to do things it doesn't usually do (like raising your body temperature to help kill off cells that are making these "rogue" spikes).

The popular media has done a huge disservice by naming this the "Indian double mutant." It's two changes that have been seen in other variants and have been studied already.

The "double mutation" is L452R and E484Q. L452R is the defining feature of the B.1.429 variant (California). E484Q has been seen in derivatives of B.1.429 and in bunches of other variants in the US. It has some antibody evasive properties, but not enough to render vaccines ineffective. Yes, the E484K mutation seen in B.1.351, P.1, and P.2 has been more studied, but E484Q has been studied too.

Double mutant makes it sound like it is something entirely novel that is going to murder us all.

I didn't see that when they launched -- wondering now if I'm blind or they added that caveat after the fact

> For slightly larger scale prosumer stuff, I might look for a way to use Ubiquiti's hardware but with something like https://hostifi.com/ , maybe with older-generation hardware that I still trusted.

For prosumer stuff -- why would you not just self-host?!? The average prosumer is never going to need more than the cheapest DO droplet to host. Or else just run it on a computer that isn't on all the time -- prosumers either already have a server on all the time or don't care if they have logs going back 5 years. This seems to cost $60/mo at the least.

Also, I do not have much faith in this company with their website being so slow (maybe too many HN people are hitting idk, never heard of them).

> They’re in control of what they tell me

Have you never interacted in a non-business sense with someone who worked customer support? They DO NOT have control of what they tell you. They will get fired real quick if they don't follow the script. Especially someone working the first line of support in a chat box.

C'mon man.

My FlexHD is perfect on my USG, so ymmv.

In the US, it's pretty rare to be behind CGNAT or not have IPv6. We're lucky in that regard.

I'd say Digital Ocean's newish Apps platform. Static sites are free and they can run a build step for you (still free).

The AT&T gateways do not have a true bridge mode. They still use NAT even if they look like they are just passing the connection on.

Even if we want to see a more innovative flu vaccine, choosing an iterative approach of getting a working one first, and then fine tuning it to protect against more variants is a good plan.

I'm thinking down the line they could put more than the 3-4 strains in the vaccine that are in the current ones (Moderna is aiming for four right now, which is what the other "industry leaders" do). But I am not an expert, at all.

There's a lot of places in the world that have not approved PrEP. And just like a birth control pill, it has to be taken daily -- and that is something that is hard for a lot of people to do consistently.

Even in the West, isn't it really expensive?

>Because he has had some alt right people interviewed on there

People paint him that way not because he has them on there, but because he almost always lets them spew their nonsense without any push back because he isn't an actually good interviewer.

This is categorically untrue.

Yes, they are deploying LTE in that spectrum, not CDMA.

It's more that most phones support most of the bands all the US providers use, so when the roaming policy changes, a lot of the phones will still work. The phone will be able to register with the roaming network.

Also, they can set up the antennas to broadcast on multiple MNCs, so it looks like a native network (i.e. T-Mobile can run LTE towers that broadcast as both the T-Mobile and old Sprint network so all Sprint phones can connect without a problem) (of course, this depends on Boost phones supporting VoLTE).

And Verizon is shutting down their CDMA network at the end of the year. It's an old technology that is being sunsetted. The problem with Sprint is that they are still relying on it for far too much (and they don't have broad enough spectrum holdings to make dual networks work well).

Additionally, a lot of Sprint's rural coverage relies on Verizon CDMA roaming -- which will be going away as Verizon sunsets their network.

I thought they fixed that in the last patch release? (Just looked, it was 11.2.5)

Are you still having the issue? My mom was still complaining about it, but I just assumed she hadn't updated her software.

Adium just got disconnected about 1:20am EST and shows an error when trying to connect. Were you using the official client?

It was pretty common to use https://github.com/tajo/react-portal for modals before React 16. It provided most (or all, I haven't really compared yet) of the functionality React 16 provides now so they've re-written it to just be a nice wrapper around the `createPortal` API.

I almost forgot how useful it was for working with webhooks! One of those things I forget about until I've been banging my head on my desk for a couple hours.

You can use ngrok without paying, you just get weird domains like n56897as.ngrok.com (this is off the top of my head, idk how close I got to a real one). This works fine most of the time.

This perfectly describes my experience with RN. Overall, a positive experience, but some days are the worst.

Very few teams have the opportunity to switch later on, and if they do, it's at the expense of the job of the person who chose to go without a framework.

Except then, no one else on your team has any idea what is going on and spends hours making minor changes. And it's probably not tested because jQuery is generally quite a bit harder to test so everyone is scared of making changes.

This a great comment. Yes you can still use jQuery and yes it's still very powerful, but it lets you shoot your own foot off too much -- and your whole team's feet are in danger too.

Angular was a huge step up in "you won't shoot your foot off-ness" and React is a step further. You still can, but you realize that you're loading the gun most of the time and can take a step back.

And that is really all this churn is about -- trying to make things easier and more foolproof. We've introduced other problems trying to solve the first couple batches of problems (accidentally using the development version of Reach on production is one I see a lot), but we'll get there.

The PHP ecosystem has had quite a bit of churn in the last 5 years too, but the yelling about it doesn't seem to be as loud since people aren't forced into it since there are alternate languages.

It's a fair assumption, but not always true, unfortunately.

And you'll still be just fine knowing those things now. There are lots of positions out there that want Backbone and Angular 1 and Ember.

Weird, just removed an old laptop from mine and didn't trigger a full page refresh.

Because there are 4 empty chairs next to one person (and the legend says an empty chair is a job posting)