glenvdb

If you're on a Mac could you just use Flux or Night Shift to achieve the same result of removing all blue light from your display?

> while peptides usually are too short to have a defined fold.

That's not strictly true. My PhD project has looked at an entire class of peptides that are known to fold in to alpha-helices when bound to a cell membrane e.g. https://www.rcsb.org/structure/2k9b.

There are many others that are known to fold into beta-sheets too.

In an earlier iteration of the web page they had really cool examples of controlling sliders, radial dials, panning surfaces, highly specific pinch gestures etc.

All of those have been removed and now it's just waving. It's cool tech and requires solving lots of hard problems, but it's a shame it falls so short of the initial vision.

> OTOH the amount of "information" needed to perfectly simulate a cell is probably unbounded. Just a corollary of the fact that we currently don't know how to perfectly simulate reality.

This is a very good point. The 'information' in a cell isn't the base pairs in its DNA, but all the atoms that make up the whole cell. And then each atom encapsulates properties such as position, velocity, charge, van der Waals radius etc.

However this considers atoms with classical mechanics. In a quantum mechanical representation it would be very different again and you can start asking really hairy questions about whether information can be created or destroyed.

Spotify bought Gimlet? Wow. I haven't listened to podcasts for a while. Sounds like a lot has changed.

I've been thinking for a while that the podcasting business is ripe for disruption in terms for revenue models.

From my understanding, podcast creators have to track down and get potential sponsors to sign on (if you're lucky and already have a big audience maybe they come to you). Then you splice in the audio of their ad into your podcast.

Whereas I've thought that an easier model for everyone would be to have an ad service that automatically serves ads into your podcast. Similar to how web site advertising currently works. As a creator you simply tag locations in your podcast where you want ads to appear and the duration of the ads. You also give the ad service a set of key words it uses to serve the most relevant ads to listeners. No chasing money and negotiating payments. Just sign up to the service, tag the audio stream, and provide relevant keywords.

An argument against this way of using ads in podcasts is that you lose control over the content and quality of the ads. I think we've all seen the broad range of quality in ads seen on websites...

The other revenue model is a packaged subscription model through some kind of syndicate. It's difficult to get people to pay for a single podcast, but if you packaged up a few under a small monthly fee maybe keen podcast listeners would be more willing to pay. Could be a good way to capture people who want an ad free experience, but don't want to pay for each podcast individually.

Perhaps I'm not aware and these models have been tried already?

I know someone who likes to create a fractal generator when learning a new language. He says it gives you a bit of exposure to the strengths of quirks in the language from implementing algorithms, working with data structures, and displaying a GUI to render an image to screen.

Before reading the article I thought this was going to be PR for a grant/fund of philosophy research.

If the dev truly understood where he wants the game to sit and why he wouldn't have compared it to Baba is You.

I think the problem is that the game is in Uncanny Valley.

It's trying to achieve a certain level of detail/realism, but it's falling short of expectations.

This might be completely intentional, to evoke a feel for games from an era that did the same thing, but comparing to Baba is You highlights the developer doesn't understand that.

Baba is You has gone completely in the opposite direction in terms of graphical detail, come out of the Uncanny Valley, and is now sitting atop Cuteness Peak.

The dev needs to decide where he wants the game to sit and why.

The overall amount of water on the planet and the annual rainfall isn't the same thing as water availability.

It's a bit "kid-ish", but I've seen it work effectively at combating what you're talking about.

Have some kind of object that a person holds while they're talking. While the person is holding the object no one else is allowed to speak. Once they're finished speaking the object is passed to the next person and they get their turn (if they want).

The object can be anything, but when I've seen this strategy used it was a rubber ball a bit smaller than a soccer ball. Something big enough that everyone can see who is holding it, not something small enough to be hidden in a hand.

As long as the person running the meeting introduces the strategy well, and maintains its rules, it should work. You might get a little bit of backlash from people that think it's demeaning, but you'll probably find that they're the ones doing the interrupting.

As someone who grew up on games during the GameBoy and N64 era, I have fond memories of gaming and want my son to grow up with gaming in his life.

But in my "old man yells at cloud" state of mind, I don't want him to grow up on gaming of today.

He's not yet old enough to play video games, but when he is I'm inspired to implement something similar to what's outlined here: https://medium.com/message/playing-with-my-son-e5226ff0a7c3

TL:DR Start his gaming journey at the beginning of the gaming industry (i.e. Pong, Pac-Man) in the hope that exposure to what gaming used to be like will "inoculate" him against what gaming is like today.

This made me realise that by the time my 2 year old son is old enough to watch adult movies, movies from the decade I was born will be entering the public domain.

I really think we're just at the beginning of utilising the the seas/oceans of this planet. Between things like this and seasteading with floating cities and farms, the world is going to look very different and we're going to be living in ways that seem strange in a few generations.