frisco

That’s exactly how you do it. You need an “actual controversy” to have standing to sue, not just a theoretical one.

Totally. This is called "adoptive cell transfer" and it's one of the hottest areas of biotech at the moment.

https://en.wikipedia.org/wiki/Adoptive_cell_transfer

There is another degree of freedom here: project cost. Why on earth does 0.32 miles of residential road cost $1.5M? Having just managed a construction project much larger than this stretch of road myself, I am certain that a lot of the blame here lies with the contracting process as well as outrageous fees (and just sheer inefficiency) from the engineers and contractors. There is no valid reason this should be so expensive. In the rest of the world, I guarantee you they are not paying over a million dollars for something like this and their standards are just as high if not higher.

I’m not sure there is an opportunity to fix this - I’ve spent a lot of time thinking about this now and modeling it out - by building a better construction company: most of the problem is, instead, essentially political.

We have no idea and there’s no real way even in principle for us to know.

Our universe is definitely not described by anti-de Sitter space. It might be de Sitter space though.

If my understanding is right, de Sitter space effectively has no boundary, in the same way that a sphere has no edge.

> proving string theory

Would definitely not consider string theory “proven”.

On the contrary, its odds of being correct (much less demonstrably so) seem to be decreasing by the year.

I had such high hopes for Keybase; kbfs had completely replaced Dropbox for me. This is terrible news.

She's 86 and just started another 6-year term last year.

Piketty’s main point is that if the return on capital is greater than the return on labor then over time you will get inequality. But like... what would a world in which that is not true look like? What would it even mean for labor to scale? I’ve thought about this a bunch and cannot imagine what such a system would look like or how it would work, except for maybe utopian socialism, which basically isn’t physical.

What kind of system is he proposing in which capital doesn’t create leverage?

CT scans involve a lot of ionizing radiation. Definitely something to be avoided unless necessary.

This is called “Special English” aka “Simple English” or “Voice of America English”. It is meant to be very clear and straightforward to understand to minimize the possibility of miscommunication and make it so that non-experts of all backgrounds can take away the important messages. Given how important the medicine supply chain is to lots of people’s daily lives, I’m sure they didn’t want this page to seem understandable only by the educated.

https://en.m.wikipedia.org/wiki/Special_English

Music production is usually Mac at this point, and that requires wired headphones/speakers. Not sure it’s big enough of a market that Apple wouldn’t drop it anyway, but Bluetooth latencies are too high to be a substitute there.

Again, the important thing is ATP, and you can get it from either glucose or ketone bodies:

> In fact, the late George Cahill did an experiment many years ago (probably would never get IRB approval to do such an experiment today) to demonstrate how ketones can offset glucose in the brain. Subjects with very high levels of B-OHB (about 5-7 mM) were injected with insulin until glucose levels reached 1 mM (about 19 mg/dL)! A normal person would fall into a coma at glucose levels below about 40 mg/dL and die by the time blood glucose reached 1 mM. These subjects were completely asymptomatic and 100% neurologically functional.

https://peterattiamd.com/ketosis-advantaged-or-misunderstood...

This statement isn't supported by any real evidence. In fact, a lot of actual research supports the idea of keto for improving outcomes in some types of cancer.

You need ATP. The Krebs cycle can manufacture it from either ketone bodies or from glucose.

I don't think this is actually true; being close to some deep learning research groups, it's really surprising how powerful GPUs have gotten. Improvements over the last few years have been very nonlinear; it's kind of astonishing. And, internet latency has also gotten very good. I bet it's totally possible to make something like this now, though most people don't realize it yet!

I am so over goal-less MMOs with simplistic pastel graphics. We've done this so many times before. How is Horizon any different from Second Life? It's really unclear. Both are ugly.

I am a huge fan of the idea of the Matrix, and I don't even think it needs to be gamified to be fun, but the graphics are such a big part of the appeal of VR for me. I would pay a lot of money just for a photorealistic VR house with a beautiful view out the windows and in-world access to my computer - a better place to hack than my usual Starbucks. Why can't we have something like the Unreal tech demos? It's clear that beautiful worlds are possible now: https://www.theverge.com/2019/3/20/18273832/epic-unreal-engi...

If a VR world that looked like the first video in that article existed, it would be huge. But the intro video for Facebook Horizon? I am completely unsold.

There is no chance they are detecting extracellular action potentials with their giant skin surface electrodes. This is 100% EMG, which is a potential produced by muscle tissue. They might be able to detect very subtle EMG signals that don't correspond to visual movement, but they for sure aren't detecting APs.

We said we were not looking at ads and that ads would never be a part of a business model for people with access to our SDK.

Super interesting. At Burning Man this year it seemed like a significant percent of the city had goTennas, which had never been true before. I also remember reading about a big mesh in Brooklyn being a thing recently. I bet we’re going to be hearing more about practical mesh networks in the coming years.

Yes for sure.

BioArxiv required at least one human author. We suggested this author list to him and, honestly, we just think it’s awesome.

I hear about these things through the grapevine in San Francisco. There's a subculture there that's all about optimizing their healthcare with as much data as possible; having seen what's possible, you really come to believe that primary care as it exists today for most people under 55 is basically a scam. I have two personal friends who are probably only alive now because they were more proactive about getting health data! (No joke, abnormalities found on MRIs turned out to be early stage cancer.) And a bunch more friends who are overall much healthier than they were before because now they have numbers to move. (Or numbers that move faster: for example, using Dexcom G6s has been catching on as a hack to lose weight because the gradient is much better behaved than a scale.) I also saw one case where someone was diagnosed with cancer and they put together a research team to help guide their treatment... and they ended up developing all this experimental medicine for him which, while ultimately unsuccessful, is thought to have added about a year of life. (Did you know that the FDA can grant single-patient INDs over the phone within one day? [0])

There's a lot of accumulated knowledge out there on how much better healthcare can be for motivated patients who can afford to pay for some of it out of pocket, but it's seen as pretty contrarian, so not discussed that openly. (Just see the other comments in this thread about how "overtesting" is a dangerous waste of resources...)

I don't know of an online community or blog that collates all this info well, but Peter Attia's blog/podcast is a good place to start: https://peterattiamd.com/

[0] https://www.fda.gov/drugs/investigational-new-drug-ind-appli...

I did Health Nucleus which includes a whole body MRI (no ionizing radiation exposure) and a bunch of other stuff geared towards looking for cancer. Apparently Prenuvo in Vancouver is considered the best now. It’s a few $k and insurance doesn’t cover it, but there are a bunch of options for self-pay to be more aggressive in primary care / health surveillance.

This stuff about “overtesting” and “iatrogenic risk” is silly. It’s one of the biggest misconceptions in medicine today. Every test has a sensitivity and a specificity and must be interpreted accordingly. Not doing that properly is a doctor problem not a test problem. In terms of spurious findings, it is usually possible to stack diagnostics until the answer becomes clear. There are lots of things between a CT and a biopsy.

...but Uber isn’t stuck with Travis?

Utah arrays overwhelmingly fail within the first year: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4868924/figure/...

"Early Decision" implies that if a student is accepted they are bound to attend that school. It's offered by colleges primarily because it greatly simplifies their yield planning. (Colleges admit many more than they actually can accommodate since they know many won't matriculate.)

This program should really be called Early Action, which is non-binding!

This is not the case. The large amounts of liquidity available means that startups are easier to fund at a given price, but does not automatically have a big impact on that equilibrium price, which is driven by venture economics. Thus just raising more / paying more is not an automatically good answer if the venture loss / return rates haven’t changed, which they haven’t.