foobiekr

Nothing says confidence that AGI is imminent like needing the US government to prevent your investments from losing you money.

Yes, and if they used it for awhile, they'd realize it is neither general nor intelligent. On paper sounds great though.

The one exception is an engineer who stopped engineering, switched into product, and transferred to China to hit on the women there.

Some Amazon practices actually sound great to me (short documents, read before the meeting) but so many things just sound needlessly, relentlessly cheap.

I wonder if it relates to this.

I had previously encountered some of that team with the SiByte MIPS in an embedded context, I know they were highly skilled, they had tons of pedigree, but PA Semi itself was a strange beast.

AI users aren’t investing actual work and can generate reams if bullshit that puts three burden on others to untangle. And they also aren’t engaging in good faith.

I have previously read that study. You should put it in context: for example, how quickly does the brain add A1 and A2 receptors for caffeine? (I already know the answer, but you might want to use it to contextualize that study).

The study about the woman co-administering venlafaxine (Effexor) which is an SNRI might be worth considering as non-representative.

Worsening suicidal ideation .. is not unique to _any_ antidepressant. Are you trying to suggest that this is somehow unique to psilocin? We were discussing prozac which is _well known to have this problem_. They got black box warnings for this reason.

As for the heart study, I mentioned this myself elsewhere, and SSRIs are showing the same issue: https://columbiasurgery.org/news/columbia-surgery-researcher... - much worse, however, because people take these drugs every day for decades.

But I think you might be missing the forest for the trees: unlike mushrooms, there is a _ton_ of research on pot specifically that illustrates that heavy use in the young is extremely detrimental to their mental health, especially young men. The studies on psilocybin/psilocin do not show this.

That said, Michael Pollan has a quote in one of his books that foes along these lines: coming to psychedelics in old age, when you are set in your ways and everything is locked in, helps you break out and reconsider things, but young people don't have those things, so the value is mostly absent.

Have you taken them with her?

Nobody other than crazy micro-dosers is taking mushrooms often enough to cause a change in receptor density and those people are putting themselves at risk of valvopathy due to 5HT2a restructuring of the heart valves (which, as an aside, is turning out to be a problem for people on prozac and other long-term SSRIs).

A drug that is very occasional, point use, with no ongoing use, which has long term treatment results, is absolutely, utterly unlike prozac.

That aside, let's say for the sake of argument that the mechanism is similar for prozac; I think that's wrong (one additional explanation may actually be: https://www.sciencedirect.com/science/article/abs/pii/S15675... ) but whatever. If so, then psilocin is vastly superior to prozac because you are not required to have continuous exposure for the benefits, as the corresponding cost, withdrawal, sexual dysfunction, weight gain, heart issues, etc. are removed.

Music, television, people talking, etc. gives you an external clock and the timelessness of the experience, one of the greatest feelings, is lost.

I guess if you're just doing them for fun it's ok.

That said, I _do_ recommend mushrooms to everyone I know with depression or anger issues.

Through direct experience, I do not think 2 or 3 good sessions and you're done is really true. Maybe with experience even that goes - you learned what you needed to learn and there's nothing more to it.

But IMHO psilocin is a strong anti-inflammatory which may in and of itself be some (not all) of the mechanism for alleviating depression (the link between inflammation and depression is strong). That will almost never be lasting.

So we may be in the case where the real breakthroughs are, as you say, in the first two or three sessions. I think most people who took mushrooms out of desperation would agree with that - by the end of the third session many of the things they needed to accept are, in fact, front of mind for awhile. But ongoing maintenance is probably useful.

Traffic laws are a hell of a lot more lax than the situation around on the job injuries.

The “add on” thing belongs in he list of tarpit ideas. Watching Cruise and Ghost Automation flail about for years vaporizing cash trapped on this idea was like watching a comedy.

Maybe they aren’t as powerful as you think outside the comparatively trivial “build some software” markets. Hell even in networking, compute and storage there are only three or four real success stories in the last two and a half _decades_.