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flobosg

3,581 karma · joined February 4, 2016

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flobosg··on 32GB of DDR5 now costs $375 – AI shortage continues to squeeze PC building
8G ought to be enough for anybody.
flobosg··on The Unreasonable Redundancy of Nature's Protein Folds
A small nitpick: chlorophyll is the pigment, photosystems are the protein complexes containing it.

> So it works. But there has got to be a simpler/better/non-toxic way to create an ion trap using proteins and make plants work better ...

I remember reading about designed minimal photosystem-like systems. I cannot find the actual paper now, though.

flobosg··on The Unreasonable Redundancy of Nature's Protein Folds
> that structure is as/more important than sequence?

Structure is determined by sequence, so they are equally important. Structure is more conserved than sequence, mainly due to the physicochemical constraints that govern protein folding.

> that "reaction centers" are what matter, and the rest is just "protection"?

Sometimes not even protection. Many enzymes can have plenty of its sequence/structure removed and still be functional. Natural proteins carry lots of evolutionary cruft.

> What do you mean by "reaction center" - surely not physically central within the folded structure

I think they borrowed the term from photosystems/photosynthesis. But, to be more precise, what they actually meant is the active site of an enzyme; the location where the catalyzed reaction takes place.

> (isn't it the surface shape that determines reactivity) ?

Shape is not enough, the chemical nature of the amino acid residues involved is also important. A single mutation in a key catalytic residue will shut down the enzyme even if the shape stays the same.

flobosg··on The Unreasonable Redundancy of Nature's Protein Folds
My PhD thesis addressed a similar question. I did a survey of sub-domain sized fragments shared between different protein folds. It turns out that there are plenty, even among folds considered evolutionarily distant.
flobosg··on The Unreasonable Redundancy of Nature's Protein Folds
This reminds me of structural studies in proteins encoded by de novo genes in eukaryotes. They are usually either intrinsically disordered or adopt a molten-globule-like state.
flobosg··on The Unreasonable Redundancy of Nature's Protein Folds
> Natural selection has no analogy with any aspect of human behavior, However, if one wanted to play with a comparision, one would have to say natural selection does not work as an engineer works. It works like a tinkerer - a tinkerer who does not know exactly what he is going to produce but uses whatever he finds around him whether it be pieces of string, fragments or wood, or old cardboards; in short it works like a tinkerer who uses everything at his disposal to produce some kind of workable object.

―François Jacob, “Evolution and Tinkering” (https://web.mit.edu/~tkonkle/www/BrainEvolution/Meeting9/Jac...)

flobosg··on Gmail thinks I'm stupid, so I left
Not sure if I understand your reply. Currently, the Sequoia beta channel is only getting security patches.
flobosg··on Gmail thinks I'm stupid, so I left
> switch to the Sequoia public beta channel!

https://news.ycombinator.com/item?id=47198977#47202707

flobosg··on I made my phone slow on purpose
One of the things that helped me is Brick (https://getbrick.com/), which blocks and unblocks apps using a small device with an NFC tag.
flobosg··on All of human cooking compressed into 2 megabytes
I was going to say the same! You can also check the recipe card here: https://www.cookingforengineers.com/recipe/19/Erics-Chocolat...
flobosg··on Rosalind: A genomics toolkit in Rust running whole-genome pipelines on a laptop
He’s talking about the past (“For a while, …”). Up to early 2010s, I would say.
flobosg··on Rosalind: A genomics toolkit in Rust running whole-genome pipelines on a laptop
A quick search gave me for example this one: https://genome.cshlp.org/content/26/1/36
flobosg··on Rosalind: A genomics toolkit in Rust running whole-genome pipelines on a laptop
> I'm not familiar with Margaret Oakley Dayhoff

Then you’re one of today’s lucky 10,000. Any time!

flobosg··on Rosalind: A genomics toolkit in Rust running whole-genome pipelines on a laptop
Or rather Margaret: https://en.wikipedia.org/wiki/Margaret_Oakley_Dayhoff
flobosg··on Earthion: A New Mega Drive-Style Shoot-Em-Up
The Red Bull Music Academy web series Diggin’ In The Carts has an episode featuring Koshiro: https://www.redbull.tv/en/page/page:rrn:content:episode-vide...
flobosg··on Venom and Hot Peppers Offer a Key to Killing Resistant Bacteria
My favorite antibiotic is fire.
flobosg··on Where the goblins came from
“No, John. You are the goblins.”

(https://doom.fandom.com/wiki/Repercussions_of_Evil#The_Story...)

flobosg··on Biology is a Burrito: A text- and visual-based journey through a living cell
If you liked David Goodsell’s illustration you can find more of his work at https://ccsb.scripps.edu/goodsell/. I’m a huge fan.
flobosg··on Craig Venter has died
How Perl Saved the Human Genome Project: https://bioperl.org/articles/How_Perl_saved_human_genome.htm...
flobosg··on Mahjong: A Visual Guide
Yes, he is! (Which explains other of his mangas, Akagi):

> He has been playing mahjong since junior high school days, and admitted that though he has rarely lost a game when he was in school, his current level of ability is average. According to him, he has "tournament luck" and has even won mahjong tournaments between mahjong manga artists. He has also participated in professional mahjong matches. He played about two games against Akagi and Kaiji's voice actor Masato Hagiwara, who is known as one of the best mahjong players in the entertainment industry, and made Hagiwara say "I don't think I can beat him."

―https://en.wikipedia.org/wiki/Nobuyuki_Fukumoto

flobosg··on Mahjong: A Visual Guide
In the Kaiji manga, the “Minefield Mahjong” arc uses a variation of Japanese Mahjong. It can be read without knowing the general rules (as I did), but I guess they make some of the scenes more understandable and/or impactful. Maybe I’ll give it a reread after checking this out.
flobosg··on The Free Universal Construction Kit
(2012)
flobosg··on Playdate’s handheld changed how Duke University teaches game design
Teenage Engineering designed the Playdate, in case you didn’t know: https://teenage.engineering/designs/playdate
flobosg··on DIY Soft Drinks
Tereré is also a milder alternative: https://en.wikipedia.org/wiki/Terer%C3%A9
flobosg··on DIY Soft Drinks
> They have made a sugar free version now as well, but that not as cool as making your own

That version (Club Mate Zero) is hard to get in supermarkets as well, at least where I’m living in Germany. I usually order it online.

flobosg··on DIY Soft Drinks
Club Mate has a different taste than traditionally brewed yerba mate. It’s carbonated as well.
flobosg··on DIY Soft Drinks
> mate tea as tea sachets

Look for “mate cocido”. La Tranquera is the brand I use.

flobosg··on Tell HN: Docker pull fails in Spain due to football Cloudflare block
See https://hn.algolia.com/?dateRange=all&page=0&prefix=false&qu... as well.
flobosg··on LÖVE: 2D Game Framework for Lua
Here are plenty of small apps developed with LÖVE: https://git.sr.ht/~akkartik, see also https://akkartik.name/
flobosg··on Twelve-Tone Composition
Also King Gizzard & the Lizard Wizard – Flying Microtonal Banana.
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