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fabian2k

12,575 karma · joined March 18, 2011

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fabian2k··on PCR is a surprisingly near-optimal technology
This is about modern PCR, which is already optimized a lot compared to early PCR. And if you're in a "normal" lab, everything around the PCR, all the handling and preparation will be such a large chunk of time that improving the PCR time alone doesn't really matter that much.

In a very automated, high-throughput setting I'd imagine that parallelizing the PCR would be the best way to increase throughput. There probably isn't that much potential in speeding up the time compared to just multiplying the number of reactions. Which is part of the point of the article.

Regarding the cheaper lab instruments, I'm not quite convinced by these ultra cheap examples. Many lab instruments need quite a bit of precision and reliability, and I would be suspicious that the cheap examples here could compete in that regard. Even PCR needs pretty exact temperature control across many individual reaction vessels. Of course the margins on lab instruments are likely enormous, and there should be plenty of potential for cheaper ones. But I don't think the ultra-cheap DIY stuff will convince people, and it'll likely also fail at the purchasing process anyway for larger institutions.

fabian2k··on My adventure in designing API keys
You don't need any encryption or signing for API keys. Using JWTs is probably more dangerous here, and more annoying for people using the API since you now have to handle refreshing tokens.

Plain old API keys are straightforward to implement. Create a long random string and save it in the DB. When someone connects to the API, check if the API key is in your DB and use that to authenticate them. That's it.

fabian2k··on X Randomly Banning Users for "Inauthentic Behavior"
This is a command to the Grok bot and used to generate an image based on the post and that specific prompt. After significant outrage they disabled it for non-paying users at least, not sure if they changed more about this later.
fabian2k··on Trump says 'a whole civilization will die tonight' if Iran does not make a deal
A previous post was "Tuesday will be Power Plant Day, and Bridge Day", so I'd guess it's about that. Destroying the entire power infrastructure of a large country like that would have a pretty catastrophic effect on civilians. So that seems worse enough, I seriously hope no nukes will be involved.
fabian2k··on The Intelligence Failure in Iran
Trump isn't even pretending to have a consistent, plausible reason to attack Iran. He never even set an actual strategic goal beyond blowing stuff up. It doesn't really matter what the intelligence said, since it had nothing to do with Trump's decision.

What happened was entirely predictable, as the article says. Iran using the Strait of Hormuz as leverage was an obvious consequences of putting them into a sufficiently precarious position.

fabian2k··on Codex pricing to align with API token usage, instead of per-message
Is this something that is likely to also change the way Github Copilot bills? Right now the billing is message-based, not token-based. And OpenAI and Microsoft are rather opaquely intertwined in the AI space.
fabian2k··on AWS engineer reports PostgreSQL perf halved by Linux 7.0, fix may not be easy
That's transparent huge pages, which are also not the setting recommended for PostgreSQL.
fabian2k··on US deploying nearly all stealthy long-range JASSM-ER cruise missiles to Iran war
The default US policy tends towards starting wars in the middle east. But even very hawkish previous administrations never started this particular one, for the reasons we're seeing right now. So I strongly doubt a Harris administration would have.

You're also ignoring just how far outside the norms Trumps administration is. They're entirely dysfunctional, breaking all kinds of laws and full of unqualified extremist with their own agendas.

fabian2k··on German men 18-45 need military permit for extended stays abroad
Nothing in there is anywhere close to the claim you made.
fabian2k··on German men 18-45 need military permit for extended stays abroad
It probably could be challenged under the German constitution, but nobody knows if that would be successful. The draft for men is set up in the constitution, but there is also an explicit equality for men and women in there. In the past any challenge would almost certainly have been denied, but it's a different time now.

In practice, this draft is not a real draft yet. Nobody is actually drafted, so there are almost no practical consequences. If there was an actual draft, I'd expect to see a challenge to this.

fabian2k··on German men 18-45 need military permit for extended stays abroad
Because it would take a change to the constitution to do that while reinstating the old draft laws only takes a regular majority in parliament. The draft is a severe limitation of personal freedom, so you can't just do that by law. The draft for men is already enabled in the constitution, the draft for woman isn't.

At this moment, changing the constitution is not possible, there is no majority for this. So that pretty much took the option to change the broader parameters out of the discussion entirely.

fabian2k··on False claims in a widely-cited paper
It depends on whether the paper is simply wrong for some reason, or if there is either fraud or a fundamental mistake in the procedure. But in general you're right, retractions are not the way to handle most scientific disputes.

Your point about consensus unfortunately doesn't quite work in cases like this were the people using the paper are not scientists. They're not continuing work in the same area, people are using this paper to support their arguments.

fabian2k··on Bets on US-Iran ceasefire show signs of insider knowledge, say experts
What scandal? They're openly corrupt and no consequences have followed so far.
fabian2k··on White-collar AI apocalypse narrative is just another bullshit
For this specific business. I don't think that is true for every business or field.
fabian2k··on White-collar AI apocalypse narrative is just another bullshit
I think the argument here is a bit of a strawman, though there is a good point in there as well. AI will not automate all customer support, but it has the potential to automate a large fraction of it.

The anecdote in there is about complex B2B enterprise software. That's not the majority of customer support, and is very heavy on escalating to actual experts.

You don't have to remove 100% of the jobs to have huge effects. Automating large parts of a few sectors would already create significant disruptions.

fabian2k··on 3M's PFAS exit killed the supply chain for two-phase immersion cooling in DCs
I don't know the details here for PFAS (and they likely would vary enormously for the different molecules that fall into this broad category). But in general a molecule doesn't have to react to be accumulated. Inert usually means it doesn't react with other substances in a normal environment. It doesn't mean you can't make it react if you add enough energy. For example nitrogen gas is considered inert. Bacteria (or chemical plants) can make it react and produce different nitrogen-containing molecules from it.

Inert doesn't really say anything about toxicity, it's not directly related to that. The opposite is though, pretty much any strongly reactive chemical is dangerous or toxic in some way since it will react with stuff humans are made from.

With PFAS the inert example is also usually Teflon. That is also a solid polymer, so not many individual molecules. There isn't much you body could do to process a macroscopic chunk of Teflon, so you'd almost certainly just excrete it.

fabian2k··on 3M's PFAS exit killed the supply chain for two-phase immersion cooling in DCs
As far as I understand the nomenclature, PFAS covers both the inert final products like Teflon and reactive intermediates, degradation products and reactants. It's a very broad category of chemicals.

My understanding is that the bigger danger is e.g. a Teflon-producing plant than the final Teflon products (assuming the Teflon isn't damaged and heated too much). Because the plant has to handle the reactive ingredients, and those can leak into the environment.

fabian2k··on Qatar helium shutdown puts chip supply chain on a two-week clock
There is no such thing as "officially closed". The moment people start shooting there, driving a ship across becomes dangerous. This was an absolutely predictable consequence of the attacks on Iran, you didn't need to wait until several tankers were burning to know these attacks were likely to happen and the strait would become essentially too risky to pass.
fabian2k··on Qatar helium shutdown puts chip supply chain on a two-week clock
Where are they supposed to put all that gas and oil if they can't transport it? I don't think they have much choice here.

And as far as I understand, helium is a byproduct of the extraction, so they can't choose to keep only the helium.

fabian2k··on Peter Thiel's Antichrist Lectures
It is disconcerting to see that quite a few of the well-known billionaires seem to have just outright insane beliefs. And those are people with real power and the ability to influence events on a larger scale.
fabian2k··on ATMs didn't kill bank teller jobs, but the iPhone did
Europe is a big place, but my understanding is that the US is the outlier here and Europe is relatively similar in this regard.

The only time I really saw checks used was when I was a child ~30-35 years ago and my parents used them. I did once cash a check from an elderly relative, but that was very unusual and only happened once. I didn't even know it was still possible to do that, my reaction was more like if someone had handed me a stack of punch cards to run on my computer.

There hasn't been anything an average person used checks for in the last decades in Germany. Except a few elderly people, nobody uses checks and there are no rebates via checks at all.

fabian2k··on US private credit defaults hit record 9.2% in 2025, Fitch says
It feels a bit like in a Road Runner cartoon. We already ran well past the cliff, just haven't noticed yet that we should be falling down.
fabian2k··on Global Stocks Sink as Oil Prices Surge
We'll see if the markets are still too optimistic here or not. I don't see how this will resolve quickly, so the Strait of Hormuz will likely remain essentially closed for quite a bit longer. I don't see any escort plans by US military ships as working, if Iranian troops actively try to disrupt this.
fabian2k··on Iranians describe scenes of catastrophe after Tehran's oil depots bombed
Trump was mostly a known quantity when elected a second time. And on foreign policy it was clear that he would be at least erratic and unpredictable. This is not an unexpected result of voting for Trump.

People voted for a vindictive and petty criminal that doesn't care about rules or laws. This is the result of that.

fabian2k··on Better JIT for Postgres
The last time I looked into it my impression was that disabling the JIT in PostgreSQL was the better default choice. I had a massive slowdown in some queries, and that doesn't seem to be an entirely unusual experience. It does not seem worth it to me to add such a large variability to query performance by default. The JIT seemed like something that could be useful if you benchmark the effect on your actual queries, but not as a default for everyone.
fabian2k··on The Age Verification Trap: Verifying age undermines everyone's data protection
That's not what this user was talking about.

For example, with a German ID you can provide proof that you are older than 18 without giving up any identifying information. I mean, nobody uses this system at the moment, but it does exist and it works.

fabian2k··on The Age Verification Trap: Verifying age undermines everyone's data protection
I'm not convinced age restrictions like this are a good idea. But yeah, the non-availability of IDs in the US is a self-inflicted problem.

Another example where this plays a role are voter registration and ID requirements for voting in the US. It is entirely bizarre to me how these discussions just accept it as a law of nature that it's expensive and a lot of effort to get an ID. This is something that could be changed.

fabian2k··on Hetzner Prices increase 30-40%
RAM increased the most, but also SSD and HDD prices increased significantly. And it seems there are also supply problems, so you can't even be sure if you get the components you want at higher prices.
fabian2k··on Hetzner increases prices from April 1
https://docs.hetzner.com/general/infrastructure-and-availabi...

This is the full list of price adjustments (it's also linked in the article). I didn't see any other official announcement by Hetzner yet, only the previous announcement about the higher setup fees.

fabian2k··on Pope tells priests to use their brains, not AI, to write homilies
How to prepare homilies is clearly a religious topic
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