ejstronge

From a different era, but still early in recorded history, you may enjoy the Excavated Shellac collection (https://excavatedshellac.com/) by Jonathan Ward.

Please share other collections if you know of any!

> Also that's a pretty common misconception, cancer is pretty well defined, abnormal cell growth

I don't think cancer biologists would subscribe to this simple definition (and it's not hard to find cases of 'abnormal cell growth' that do not ultimately constitute cancer). There have been, and continue to be, publications that pose the question of what it means for a patient to have cancer (cf https://www.cell.com/fulltext/S0092-8674(11)00127-9 )

Cancers quite clearly cause different diseases - it's even the case that cancerous cells can yield distinct clinical presentations simply based on whether they are primarily found in the blood or in solid organs.

I don't think anyone would disagree that 'viral infection' is also an unhelpful description. Viruses may transiently infect host cells and die out (the common cold, for example) or permanently become part of the host genome (consider the various herpesviridae).

HPV causes multiple lesions in humans, including warts.

Certain types of HPV are more associated with certain lesions over others, but the broad range of HPV targets means that dangerous HPV types could be transmitted through relatively innocuous means.

Some context: https://www.ncbi.nlm.nih.gov/books/NBK448132/

> ISIS

Are we remembering the same 2010s?

Also, all of what you’re quoting stemmed from the Obama era (except the moving of the US embassy)

Within the contexts of their written rules…

And maybe you’ve forgotten how the RNC rules were changed to support their candidate?

This isn’t an uncommon presentation - disease processes that lead to inflammation of the small bowel can be expected to resemble gluten sensitivity.

Gluten consumption, on its own, can cause small bowel inflammation and this effect is well known (see https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5677194/)

> Also the blood cancer has already killed one of the patients

This isn’t a fair interpretation of the death - the treatment of the drug-linked cancer bears a risk of multiple complications. One of these complications led to a patient’s death.

> The entire concept of inflation comes from the fact that various Med. cultures figured out you could issue coinage with a high percentage of gold and then slowly drop the percentage over time to increase the purchasing power of the government. It got insanely bad at some points, with "gold" coinage being less than 50% gold. Inflation wasn't just constant, it was an everyday fact of life.

I'm not an expert on this - how does this idea differ from that of 'seigniorage' where the sovereign can profit from the creation of money?

Your example only addresses the buying power of the sovereign; it's not obvious that it should affect the prices of goods between private parties.

https://en.wikipedia.org/wiki/Seigniorage

> Lenders, fearful of being left holding the bag

This is where the logic breaks down - lenders are selling these mortgages irrespective of any other conditions.

The only loans that aren’t sold are unsaleable investor and boutique loans. These wouldn’t be offered to normal borrowers in the first instance (since the loans of a normal borrower would be targeted for resale)

> That works out to ~$22 per American per year. Not sure what Visa's operating costs for their network are, and I'm no big fan of them (or any other credit card company) but that's far cheaper than I would have expected

You’re assuming quite a few things - the most significant are that the cost is borne equally among Americans. Instead, many Americans use credit card networks instead of debit cards, and those who use debit cards may have no option to avoid the fees.

> As someone who is very interested in AI and taught myself how to code (I don’t know any other real estate people who know anything about code), I think it’s going to be incredible hard to uproot the brokerage industry.

Has learning to code generated any benefit to you? What areas do you think have space for code to help buyers?

I think there are many, and - 'AI' or not - a clever tool can generate real value for buyers. Things like mis-zoned units, unreported square footage, signs of buyer motivation, estimates of homeowner equity, etc. can be estimated by good buyers agents but could be made available to everyone for a small subscription.

A relevant excerpt from the complaint:

> RealPage-defined submarkets identified in Appendix A are relevant markets in which the agreements between RealPage and AIRM and YieldStar users to align pricing has harmed, or is likely to harm, competition and thus renters. In each of these markets, the penetration rate for at least (i) AIRM and YieldStar, or (ii) AIRM, YieldStar, and OneSite ranges from at or around 29% to more than 60%.10

> Journalists" now love to use a sequence of events and then present them like a causal narrative, ignoring the real reason the final event happened. I'm so freaking sick of it.

When was journalism, writing, or any sort of story-telling not done this way? Is the alternative a series of time stamped actions?

> A small truck has just as much possibility to kill as a big truck, and in fact due to the smaller application of similar forces its more likely to seriously cripple you, even if said hit was non-fatal. > While I’m all for reducing the size of cars in USA, pretending that ”massive modern trucks” are the only ones that kill is just wrong.

The argument is that a larger truck is more likely to kill - instead of resulting in injuries that can be treated. There is evidence for this.

Daylight means a field whose elevation is below the area to be drained in this case

Both of these links include a dry well - if one is draining to daylight, how do you incorporate the 100-yr flow rate?

>Calculate how much water you actually need to drain. You can use the “100 year flood” values for your locale to get an upper bound on rainfall, then multiple by drainage area

How do you incorporate this into a drain design?

It is rare in my part of the world, but it isn't (currently) rare in places where roofs don't have to withstand snow. No comment on the historical trend.

> Apartments have the opposite situation for weird legal reasons; there are almost no condos built in California anymore because the laws allow the original developer to get sued over quality issues, whereas for apartments the landlord has to deal with it.

This feels like it confuses a couple of issues - one really needs to know the recourse a homeowner has against a home builder and how long this lasts (and to compare that recourse to what is available to condo owners)

> You're just trying to ban apartments here. Corporate SFH housing basically doesn't exist but mom and pop large apartments don't either.

This definitely isn't true - there are markets where apartments aren't allowed/desirable, and in which corporate actors 'build to rent' entire subdivisions.s

> i.e., gene editing (by whatever means) is not really a win any more than changing bits in memory is. The win comes from having an in-vitro model that replicates the in-vivo disease

I take your point, but this would have been a challenging, expensive endeavor before CRISPR-Cas9. Likely, the perturbation would not have been done in the same paper as the announcement of the locus due to the challenge of deletion work before CRISPR-Cas systems became readily available

> said that government regulations forced lenders to accept more default risk--meaning they were forced to lend to people they would not otherwise have lent to because the risk of default was too high. That's what "subprime mortgages" means, and those were a huge contributor to the crash.

The ratings agencies are free to rate things as they wish - unless maybe you’re saying there’s a government directive to misrate things?

Also, please clarify how the government is compelling lenders to make loans that don’t pass the lender’s underwriting criteria… this is news to me

> for example the US government wanting to encourage home ownership and skewing the mortage [sic] market and the money supply and requiring lenders to accept more default risk

Are there economists who share your view on this? I don’t see how the issue of repackaging CDS and related products by a financial rating agency has anything to go with the government.

If you’re saying that the government forced buyers to abandon due diligence… I think we will have to disagree about the facts of the GFC

What is ‘socialized medicine’ in your understanding? How does what you are proposing differ from ‘socialized medicine’?

Here is the Cell article: https://www.cell.com/cell/fulltext/S0092-8674(24)00459-8

I’m not a domain expert, but I haven’t seen ECMO offered to ‘old’ patients (over ~70). Do you have data on ECMO recipients’ age?

I’d be careful interpreting studies when you aren’t a domain expert. Even if the results are accurate (no reason to think they’re not in this case), subtleties of experimental design that a domain expert would see may be invisible to an outsider.

In this area, some groups are able to demonstrate a benefit and others are not. The thought is that hospital integration with field technicians is a big explanatory factor

Another way to think of this is that 'autism' is a broad series of disorders where individuals do not follow the social-relational cues we expect. There are many ways to violate unspoken social expectations, so there should be many ways to be autistic.

In this setting, it's not unreasonable that any genetic syndrome would be more associated with autism; indeed, it's more interesting to find lesions that have a lower proportion of autistic carriers compared to the general population.

> I know that episode. It's actually called "Abby Makes Season Change", [1] so that "series of words" is the direct answer to the question. The point is probably true in general, but the example sucks.

Are the episode names of Sesame Street displayed in the episode?

> When was the over supply.

A google search for '1990s physician oversupply' will give you many articles, like this one:

https://www.bmj.com/content/312/7026/269.1

> Educating doctors is really expensive. It would really suck to invest all that money in someone (or in yourself) just for them to fail a final test or whatever.

This happens already, today. There are dozens of reasonable questions you can raise based on this fact - but I don't think it's obvious that the failures at the end of training can majoritarily be identified by pre-training metrics.

Some countries allow any student to take the first two years of medical courses, and then impose restrictions on the following years. This seems a relatively fair system; you can imagine someone persevering over many years to attain the requisite knowledge - but this person would not have had the opportunity if there were a pre-medical school filter