Detroit is also strongly conformist. But, ever present threat of crime lords 90% of the hold-up. Look what happened when Dan Gilbert go the cops to clean-up a couple blocks of downtown!
49 karma · joined May 25, 2020
I, a millenial that pays $2k/bedroom, am always struck by the portrayals of the 1960s where people in their 20s live 10 to a loft and make rent working a few nights a week at the bar downstairs.
I'd just like to recommend against using thalidomide as an example of chiral effects. Rather unusually, thalidomide has a nitrogen atom as its chiral center. As such, it rapidly racemizes (interconverts) at physiological pH. This makes the claim of stereospecific teratogenicity a bit puzzling as it shouldn't be possible to resolve by administering enantiopure thalidomide.
The mechanistic story of thalidomide is a bit complicated. Ultimately the mouse and rat models used couldn't possibly predict teratogencitiy as these models have an amino acid mutation (valine -> isoleucine) that prevents binding of thalidomide to Cereblon, the protein that mediates thalidomide's teratogencitiy [0]. Amazingly, although this story is oft-repeated, its origins are unclear. This is likely the origin of the myth [1], but knowing what we know now these results should be impossible.
[0] https://elifesciences.org/articles/38430 [1] https://pubmed.ncbi.nlm.nih.gov/583234/