curmudgeon22

I typically do a Noon to 8 PM eating window, which works for me. I agree with you, much easier to skip breakfast than to skip dinner. Also, I do more social eating for lunch/dinner.

The sales people in tech i know get pretty good base pay ($150-250K).

+1 for a decent wet shave razor.

Thanks, TIL.

Personally, I've decided chia seeds are a good way to get more fiber. Also a good source of omega-3s. More calories than some other options, but I like the idea of whole foods. They have a decent mix of soluble/insoluble fiber.

Agreed, this version is better

In addition to testing with mice, they also tested in human cells:

> UBC researchers tested four variants, including Delta, in human lung cells and organoids, tissue cultures that can mimic the organ they’re taken from, and found that N-0385 inhibits infection, with no evidence of toxicity.

https://www.nature.com/articles/s41586-022-04661-w

My thought on the most likely confounding factors is both requirement and proclivity to get tested. Vaccinated/boosted folk are more likely to be in situations requiring testing, thus finding more mild or asymptomatic cases. I'm not sure on who is more likely to get tested of their own volition for mild symptoms and could see arguments both ways, but could see it being a factor.

Agreed, the deaths by vaccination status shows a stronger benefit, particularly with age.

These are rates per 100,000 for vaccinated, boosted and unvaccinated from Ontario (population 14 million). I don't see much benefit against infection to those with 2 or 3 mRNA doses.

The most recent datapoints (7 day average):

- Not fully vaccinated: 14.86 cases per 100,000 people

- Fully vaccinated: 17.39 cases per 100,000 people

- Vaccinated with booster: 26.89 cases per 100,000 people

https://covid-19.ontario.ca/data/case-numbers-and-spread#cas...

> "Knowing where the chips go is probably a very good thing. You could for example, on every chip put in essentially a public private key pair, which authenticates it,” and allows it to work, Eric Schmidt, the former Google chairman, told Reuters in a recent interview, discussing high-end processors.

> Sberbank believes that the new app update may contain a virus. Users were asked to temporarily refrain from updates.

With Google translate:

> From March 10, Irina Elina will not be able to access her Russian bank account, a consequence of the sanctions against Russia. Irina Elina, who is a student in Uppsala, is preparing for the worst.

It's not a vaccine, but there are existing nasal sprays [0] with iota-carrageenan, which has anti-viral properties and has been shown in-vitro [1] to be effective against covid:

[0] https://www.betadine.ca/nasal-spray/

[1] https://journals.plos.org/plosone/article?id=10.1371/journal...

> Conclusions

> Our study is the first in vitro study on the effect of COVID-19 mRNA vaccine BNT162b2 on human liver cell line. We present evidence on fast entry of BNT162b2 into the cells and subsequent intracellular reverse transcription of BNT162b2 mRNA into DNA.

It will be interesting to see how effectively the government can reduce access to crypto.

With significant notes in 2008 and 2014 :)

> What I recommend instead is to separate your money from your love. Get the most low-stress source of income that you can find, and then do exactly what you love for free. It might eventually make you money or it might not. "Do what you love and the money will follow" is mostly false. The real rule is: "If you're doing what you love, you won't care if you never make any money from it -- but you still need money."

If the 31% figure turns out to be relatively accurate, that's not very durable.

> VE after 3 doses declined to 66% among those vaccinated 4–5 months earlier and 31% among those vaccinated ≥5 months earlier, although the latter estimate is imprecise because few data were available on persons vaccinated for ≥5 months after a third dose. The decreasing trend of VE with increasing time since vaccination was significant (p<0.001)

> But the lion’s share of the directorate’s work is envisioning the technologies that are generations ahead of what we have today. It operates almost like a small, elite technical college, organized around five academic departments—math, physics, cyber, computer science, and electrical engineering—each staffed with 100 to 200 people.

> The physics department, which Herrera once directed, runs dozens of laboratories that conduct most of the work on quantum information sciences, but it has a much wider remit than that.

> Military competition is accelerating, but there is also dissemination of other technologies, like synthetic biologies, that are frankly alarming. The role of research is to help the NSA understand what the impact of those technologies will be.

> Everyone thinks their data is the messiest in the world, and mine maybe is because it’s taken from people who don’t want us to have it, frankly.

Here's the Study: https://www.researchsquare.com/article/rs-1121993/v1

> Thirty-six healthy volunteers aged 18-29 years old were enrolled according to protocol-defined inclusion/exclusion criteria.

> All participants were inoculated with 10 TCID50 of SARS-CoV-2/human/GBR/484861/2020 (a D614G-containing pre-alpha wild-type virus; Genbank Accession number OM294022) by intranasal drops (Figure 1b). Eighteen participants (53% according to the per protocol analysis, [95% CI [35,70]) subsequently developed PCR-confirmed infection.

I think the best bits from the article are:

> Right-wing commentators sought to discredit these protests [1980's peace movement] by heavily featuring and platforming the most off-topic or the most radical protesters and then seeking to paint all protesters with that broad brush. This approach generally failed and was mocked by the mainstream press, who depicted the diversity of protesters and homemade signs as a sign of the depth of its support.

...

> And, in progressive, urban Canada, this broad-brush guilt-by-association strategy exhumed from the 1980s appears to be working, no matter how intellectually lazy its journalistic practitioners are being. Let me rehearse the kinds of sloppy reporting we are seeing here:

> He opened up about his out-of-the-blue, dream-come-true windfall, the letdown when he realized he topped SpaceX’s weight restrictions of 250 pounds (113 kilograms) and his offer to the one person he knew would treasure the flight as much as himself. Four months later, he figures probably fewer than 50 people know he was the actual winner.

> The changes are as follows:

    WFH guidance dropped from today
    Covid passports no longer required from next Thursday
    Face masks in schools dropped tomorrow
    Face masks in the wider community dropped from next Thursday
    Covid self-isolation stays although likely to go from March 24

Fair point, why does this correlation only manifest now, not sooner? Also tough to guess at how much this might skew things.

Have a look as these case rates by vaccination status, per 100,000. There is a higher case rate among the fully vaccinated since late December.

Would you have a meal with a vaccinated family member? Why is that safer than a non-vaccinated?

https://covid-19.ontario.ca/data/case-numbers-and-spread (COVID-19 cases by vaccination status)

There are risks from the vaccines, even if they are rare. Why expose yourself if you're protected already?

Myocarditis being the main one:

- Postmarketing data demonstrate increased risks of myocarditis and pericarditis, particularly within 7 days following the second dose. [1]

- The true incidence of myopericarditis is markedly higher than the incidence reported to US advisory committees. (preprint) [2]

[1] https://www.fda.gov/media/151707/download

[2] https://www.medrxiv.org/content/10.1101/2021.12.21.21268209v...

Pretty neat overall. I thought this was an interesting random fact:

> The key role of ice crystals dovetails with recent findings that lightning activity dropped by more than 10% during the first three months of the COVID-19 pandemic. Researchers attribute this drop to lockdowns, which led to fewer pollutants in the air, and thus fewer nucleation sites for ice crystals.

This study says much less than 71% reduction, 25% of vaccinated and 38% of unvaccinated people got Covid when living with an infected person.

https://www.bmj.com/content/375/bmj.n2638

> EDITED TO ADD: It’s actually worse than I thought. Edge urges users to store passwords, ID numbers, and even passport numbers, all of which get uploaded to Microsoft by default when synch is enabled