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corin_

10,404 karma · joined May 23, 2010

I do marketing & other business stuff in the games industry.

Email: c@corincole.com

(Yes please change to swores)

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corin_··on Email from Jeff Bezos to employees
They announced quarterly earnings of literally double what analysts were expecting at the same time, which would have sent the stock to a bigger rise had it not been balanced by his news.
corin_··on GameStop Is Rage Against the Financial Machine
It's not that they're literally irrelevant as in have no effects; they're just irrelevant in the thinking of who you're trading with - no matter how complex the algorithm it's still buying or selling on behalf of a person or company.
corin_··on MasterCard to push up fees for UK purchases from EU due to Brexit
Yes so far but it's very early in the vaccinations. Feels equivalent to making a judgement on worst country for death toll in March last year.

(As a Brit, I'm pleasantly surprised how smoothly our vaccine roll out is going so far!)

corin_··on MasterCard to push up fees for UK purchases from EU due to Brexit
The UK could have chosen to take part in the EU schemes any time last year had it wanted to.

Equally, any EU member state could have chosen to go their own way. The EU didn't force them to collectively bargain to (successfully) get better value deals.

Maybe the EU will do a worse job distributing, but it's too early to say.

corin_··on Moderna vaccine appears to work against variants
Even if they cant, for the period when there are lots of people vaccinated and also lots of people infected, that's lots of mutations happening in infected people and then trying to jump into vaccinated people, giving it more chances that one of those mutations would then spread from vaccinations people even if current mutations don't (which isn't known yet). If it spreads from vaccinated people already then that would be even worse.
corin_··on 18.7 Million Americans Vaccinated
Very sorry to hear about the person you know with Bell's Palsy, I wish them well and with some luck hopefully they'll recover from it and get back to normal.

However, there is not yet any evidence I've seen that the vaccine can cause Bell's Palsy. There's not conclusive evidence it can't, but the FDA says: "The observed frequency of reported Bell’s palsy in the vaccine group is consistent with the expected background rate in the general population."

https://www.snopes.com/fact-check/covid-vaccine-bells-palsy/

(Please do correct me if I'm out of date and there's anything showing statistical significance, but I don't see anything new from a quick Google.)

When you vaccinate a lot of people, some of them will develop medical problems that would have developed regardless of the vaccine. It's not impossible you will be proven right once there is more data, but until then it is spreading misinformation to say that the vaccine did cause the problem.

corin_··on 18.7 Million Americans Vaccinated
The fact that it's mRNA isn't really relevant to how your body fights the virus, it's still the same mechanism.

The traditional way (as used by the Oxford/Astrazenica covid vaccine, and others) is to show the body what the virus looks like by giving it non-harmful bits of protein that look like the bit of the virus the immune system will need to recognise.

The mRNA ones (like Pfizer's or Moderna's) use mRNA code to tell your body to create those harmless proteins, and then the rest is the same - your immune system learns to recognise them, which is good because it will be more likely to recognise the real virus.

The mRNA technique is just moving the "create these harmless things" from the lab to inside the body. It doesn't change how your body fights the virus compared to traditional vaccine methods.

(mRNA vaccines have also been undergoing safety tests for years, these ones for covid are the first approved but not because previous/ongoing ones were shown to be unsafe.)

e.g. info from CDC: https://www.cdc.gov/coronavirus/2019-ncov/vaccines/different...

corin_··on 18.7 Million Americans Vaccinated
There's no evidence yet (that I'm aware of) which is why experts are very cautious against giving false hope.

But based on past vaccines for other viruses and the way they and the covid vaccines help your body be better prepared to fight the virus, it's a reasonable guess that they may well at least limit spread, perhaps even close to prevent it.

So you're right to point out that it's not a sure thing, but I (admittedly, not an expert, but basing on views of experts) also think it would be more surprising if the vaccines didn't slow spread at all, the bigger question will be to what extent (both with and without current protective tools like masks and social distancing).

corin_··on Baffling Brexit rules threaten export chaos
It's literally going to hurt the future of music/art that has working class roots more than it will that of people who can afford to go longer without making money before finding success.

To frame it like the person you replied to did, as working class people vs. elite artists, is incredibly shortsighted.

corin_··on Forever chemicals are widespread in U.S. drinking water
The same way we know about lots of products, by the company and/or third parties testing them? The same way we "know" how much of a drug is in a pill bought from a pharmacy, or the % of a chemical in a bottle of cleaning stuff, or....

Obviously there can be cases of companies being misleading or completely fraudulent. But generally speaking you aren't testing every cosmetic, food, clothing etc. to be sure that they're made the way they claim, why would water filters be different? Legislate certification for them if needed, rather than worry about how hard it is for a single person to test at home.

corin_··on Most surgeries are ineffective
> In other words, finding differences in effectiveness of different intervention approaches must mean that either some of these interventions are better than placebo, or that all (except maybe the best one) are measurably worse than performing no surgery at all.

That doesn't tell you anything useful about them vs. placebo though? And "all (except maybe the best one)" seems to be entirely gut instinct not logic. You don't need to even try the surgeries to know that either all, some, or none will be better than placebo.

If both types of surgery perform the same, they could both be better, both be worse than, or both be the same as placebo. If one type is better than the other then maybe they're both better than placebo in different amounts, maybe both worse in different amounts, maybe one better the other worse than placebo, maybe one is same as placebo and other better, or one the same and other worse.

Knowing that two surgical approaches give different results gives no hint as to where placebo would perform in comparison, just that it can't be the same as both of them. It can still be better than both, or worse than both, with no reason to suspect one more than the other without other priors or actually testing vs. placebo.

corin_··on We are sending more foster kids to prison than to college
Yes of course doubling would be a game changer! Think of the huge amount of good stuff already covered in healthcare and social services, even a 10% increase in budget could do a massive amount of good.
corin_··on I Think Beethoven Encoded His Deafness in His Music
I obviously can't speak to Beethoven, but I have witnessed a couple of very successful modern composers (of classical music) - just in passing now and then, I didn't sit down and study their methodology, but can definitely vouch for having seen extremely talented and successful composers sat at a keyboard instrument tapping out ideas.

No doubt they, like Beethoven, would be much more able to compose some if not all in their heads than i would be, but it doesn't mean they don't still find useful, at least sometimes, basic stuff that amateur composers do.

corin_··on I Think Beethoven Encoded His Deafness in His Music
I feel that way about the idea of coming up with a simple tune after going deaf, but hearing a full symphony you're composing while deaf is a whole new level.

Then again, despite being a professional singer when I was young and then attempting to study composing I discovered I have no skill for it - so composing even a simple orchestral piece without being deaf seems complex to me.

corin_··on I Think Beethoven Encoded His Deafness in His Music
While an organ has a similar interface (keyboard), it's such a different instrument really, in terms of the noise it makes, and various other elements like the length of noise from a key press. He would have had to actually want the organ as the instrument in the piece for how it is, not just for offering a greater range than an early pianoforte.

So it could well be that he would have preferred to use the organ's range earlier but just not wanted that instrument in his music. And that's not necessarily an insult to pipe organs - I think they sound lovely, watching somebody play well can be as enjoyable as almost any other instrument, and I'm a big fan of them in their place. But their place is pretty niche really - there's lots of lovely (but religious) choral works that use one, due to churches historically, and there are nice things written for organ. But it's pretty rare for organ to be the keyboard instrument of choice in orchestral music, chamber music, etc

corin_··on Tell HN: Dropbox now requires access to contacts for Google login
I have it turned off in my profile, which works nearly everywhere, but doesn't have any effect on the Apple TV netflix app.
corin_··on Tell HN: Dropbox now requires access to contacts for Google login
They become multi billion companies by having different incentives (making profit) than the enthusiasts.
corin_··on Odroid-Go Super: $80 Games Console That Looks Like a Switch, but Runs Ubuntu
If you set up your PC with a joystick and no keyboard/mouse...
corin_··on Google admits to running experiments which remove some media sites from results
This article is about experiments in Australia, I don't see much relevence to American politics other than coincidental timing.
corin_··on U.S. to require negative Covid-19 tests for international air passengers
Considering how many immigrants and children of immigrants live in the US, even if the people you saw seemed very diverse they could maybe have been primarily US citizens not foreign tourists?
corin_··on Moderna is announcing three new vaccine programs
Also worth mentioning that while we don't have an exact "cure" for HIV, we do now have treatments that (if you or your country can and will pay for it) can make having HIV into something that not only doesn't ruin your live, but that even can't be spread from you to people you have sex with.
corin_··on YouTube bans Steve Bannon's podcast channel
Most of the world including New England still locks people up for moral infractions, even if no longer using stocks.
corin_··on MakAir: Covid-19 ventilator with a Raspberry Pi
Could you please share any sources? I know they're not used as much now but haven't seen any evidence that they are specifically to blame for deaths.

The majority conclusion I've seen in Europe about why earlier death rates were so high in some places was that the hospitals were overloaded and therefore didn't have enough capacity (staff, equipment, etc) and therefore some died due to there not being enough ventilators.

This isn't my field of expertise so I'm very open to finding out that my impression is wrong, but my gut feeling is that your comment is not accurate.

corin_··on Oxford-AstraZeneca coronavirus vaccine approved for use in UK
You're right, but there's a difference between "it's not worth spending millions on an operation to slightly improve an unimportant part of someone's little finger" and "I have two people who will die if I can't treat them, and due to limited staff/hospital space one of them isn't being sent for treatment".

So yes, it's not binary between normally being infinate and now not, but it's also a bit too reductive to make that point without also being clear that Covid has caused more and worse triaging than usual. (But someone needed to make your portion of that point and you did it much better than I could have, so thanks!)

corin_··on Pierre Cardin has died
It's possible to consider "why has HN found this interesting" without also thinking "this shouldn't be on the site!".

I'm very much onboard with what you wrote, but I too saw this post and wondered what it was about him that took his death to HN's front page.

corin_··on UK warns people with serious allergies to avoid Pfizer vaccine
This has not been announced, unless I've missed it in the last 36 hours, only speculated about.

There are NHS vaccination reminder cards which you'll be given at your first appointment and recommended to keep in your wallet - with sticker(s) of what dates you had / will have jabs, and a little info about how to find out more info.

This is standard NHS practise for vaccinations that require multiple spaced out injections - I've had two cards pretty much identical to the photo I've seen of the covid ones in the last few years, for other vaccines from the NHS.

The UK's Health Minister confirmed to Sky News yesterday morning that they are not for providing proof you've been vaccinated, and that they do not need to be kept after your final injection.

corin_··on The Death of Tony Hsieh: A Spiral of Alcohol, Drugs and Extreme Behavior
You're ignoring the fact that this is despite huge restrictions around the world to limit its spread, if approached the same way as TB it would do insanely more harm.
corin_··on Reddit Claims 52M Daily Users, Revealing a Key Figure for Social-Media Platforms
I don't know if it would affect Pepsi's or McDonald's sales, but it would likely affect somebody's career at their marketing agency (not in a good way).
corin_··on EU criticises 'hasty' UK approval of Covid-19 vaccine
No that's not it.

UK is getting this vaccine first because MHRA approved it before EMA did (and any EU country is allowed to use this shortcut that MHRA is so far the only one to have used), not because we have a deal to get it first.

corin_··on No one who got Moderna's vaccine in trial developed severe Covid-19
These Covid ones aren't the first that have been tested and shown safe in humans, but I believe they will be the first to be approved for release.
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