(disclaimer: I go to Saint Louis University, but spent last semester in SF)
I don't know what you're talking about - it's really not that bad.
For example: the STLJS meetup just started less than a year ago and had over 50 people at our last meetup. Granted - it's not SF or SValley, but it's not the hell hole you make it out to be. There are some of the most genuine and kind people I've ever met that are here in STL.
We're not a bunch of dumbfucks. Hell - WashU is ranked the 14th best university in the country. I'm not one that thinks a great school is equivalent to intelligence, but c'mon - there are people here that think. A lot of them. Just not the same way a bunch of HNers do.
It's just a different culture here. People are much more corporate and family-focused, which isn't a bad thing to a lot of people.
With that being said, StartupWeekendSTL was here a few weeks ago, and there were too many people to fit in the place we had. It was awesome!
Think what you want, but if you really think St. Louis is that bad, then you're just not reaching out for the culture you're looking for, sorry.