bpizzi

Yes but... no one is dumping anything remotely random here :)

It's using existing building mechanism in cells to have it build a specific protein that will bind to a specific pathogen.

And lot of clinical tests to try to detect if those proteins being built have other effects than instructing the cells to create the antibodies we want.

It's roughly the same mechanism at work when you inject disabled pathogen and hoping that the cells will produce the same antibodies, it's just a faster, safer, more precise way to induce it.

Heck, it's even the same mechanism that occurs when your cells encounters a wild, random virus, like it may be happening a lot more than you think, and, well, you're still alive :)

By the way, you may be thinking under the assumption that the 'program' is the DNA, and that mRNA vaccines is changing it some way or another, which is not, this is not genetic therapy.

I fail to see what is terrifying, exactly? Care to elaborate?

Also interesting to note that this is a mRNA vaccine, where the production of antigen within the cell is induced by injecting a RNA sequence instead of a disabled virus.

Anyone who's using Esc to return to normal mode isn't a hacker imho.

Sarcams aside (I'm referring to `:imap jj <Esc>`), I would say that sticking to staggering is the real sin here.

I don't get it, I may be missing some context thought: why the author didn't go for running said webapps directly on the VPS in the first place? Why bother running it on the Pi and set up the tunnel (which is a nice hack in itself, I get that)?

Not even sure there's a decent internet connection down there :)

The comparison isn't really meaningful thought: this french castle is in the middle of absolutely nowhere. You are 2h away by car from the either Bordeaux or Nantes, which are your closest chances to find an IT job.

That data speaks for itself.

And we're still talking about an average output. When wind will not blow enough for meeting consumption then additional energy will be drawn from other sources, and it will, it already is.

Renewable energy is great but it is a non-viable option as a main energy source.

> Flamanville reactor in France was supposed to cost 3.3 G€ in 2007, it is now at 19.1 G€ in 2020 and called a "mess" by energy minister (https://www.montelnews.com/en/story/french-epr-is-a-mess--en...).

Your information is very misleading, very.

The quote come from the minister of the ecological transition, not 'energy minister', whose official duty is, quoting wikipedia 'responsible for preparing and implementing the French government’s policy in the fields of sustainable development, climate, energy transition, and biodiversity.'

This new minister has a political degree (Science Po), no technological background, and is member of the local pro-ecological party since 2000.

Of course she's referring to EPR as a mess, which is true in a certain way, but in her mind it's just a political stance she's feeling obligated to say publicly.

Of course the EPR is a giant project, maybe too giant, of course it was underestimated in order to get it going, and of course it takes much longer to be built than every one would want.

But that's the price of technological advancement, that's how we learn to build better things.

And what's the alternative? 1650MWe of wind turbines, where would you put it?

> The 21st? The iPhone? Meh.

Only 20 years in (or is it 'already 20y in'?), and there's already reusable rockets, CRISPR, 3D printing and the combo deep learning + astonishingly both powerful and affordable CPU/GPU/TPU.

I would say this is already an interesting century, invention-wise.

Also, one could argue that the 21's internet is not the same as the 20's, in which case modern, cheap and massively deployed internet can be classified as a 21st great invention.

But we're splitting hairs. Centuries are an artificial construct. Measuring pace of change by such a crude method makes no sens to me.

Somewhere almost at the end there's a 'level' where the player need to walk across the ocean floor under a rough 'weather', be sure to check that part out, it's a highly immersive experience.

There's some effort to port it to VR, I can't even begin to fathom the kind of feelings that could emerge from such an immersion (pun intended, the game sets stage on the ocean floor).

Well, according to the Big Freeze theory (seems to be the most probable) 500 million years is less than a blink of an eye when compared to the time the universe will consume until it cannot anymore.

We aren't 'fucking' with the way nature works. You're failing to see the big picture here. We are part of what you call 'nature', surely you'll agree with that being a non-believer, so at least you should say 'I think the nature shouldn't fuck with itself'.

But, still, there would still be no 'fucking', seems like a total nonsense to me.

Completely relevant.

There's a variant where you don't need CF: compile/install Caddyserver on your box, let it handle the LE certificates by itself, and use it as a reverse proxy to deliver the request to your current webserver.

Caddy being a stand alone binary (it's even possible statically link GLIBC), you can even work yourself around an old distro and dependencies nightmares.

Caddy's config file is on par with Nginx in terms of simplicity, the learning phase is quiet small, I would even say nonexistent for someone with a technical background as OP.

Ho, sounds exactly what I'm in the process of laying down at work!

Do you push to on premises deployment or is it pure saas? The former is obviously harder to tackle, and unfortunately that's the case here.

Those are beliefs from the past. Given time it will change. What human kind is biologically hardwired for is personal survival ability, not leaving the world for youngsters as soon as possible, and those two precepts are mutually exclusive.

Those beliefs you spell are quite absolutes to me. Humanity is not made after a single mind model. What you take for granted (« nobody has endless capacity for creating the new ») might very well be an utterly false premise.

Right now unsupervised learning techniques aren't able to teach a meaningful world model to a neural network.

But this won't last (hopefully), thanks to our brilliant co-humans doing cutting-edge research on that subject. And when a neural network is able to differentiate and anticipate possibles actions of winds, engines, birds and onboard electronics, then you have an autonomous take-off on par with humans pilots, enhanced with an instant feedback loop with built-in checklists and avionics.

It's a big stretch of course. But never say never, they say.

Greetings, fellow prog-metal buddy.

You should aim for orthogonal and spitted keyboards. Big changes, you possibly need to relearn to type, but potentially life changing. One model among others which is safe for recommendation is Ergodox EZ. Warning: not cheap, none are.

Yes, dedicated alarm clock indeed. However I wouldn't count "swiping the alarm off" as a valid case of "looking at my phone first thing in the morning" if you just stick to turn off the alarm.

While I just had to check if there was such a "time tracker" on my iPhone. Yes there is and I had not activated it.

The text starts with "there are a thousand beautiful ways to start the day that don’t begin with looking at a phone. And yet so few of us choose to do so.".

Is it really so? I'm only a single datapoint, but checking my phone is the last thing I do in the morning. Getting children up, coffee, shower, planning some today's work in my head - if the phone isn't ringing then I may well not fiddle with it until later in the morning or even the day.

Here are counterarguments for counterbalancing your pessimistic view, do what you want with it: humans are not stupid, and god doesn't exist.

Exactly.

I see downvotes on my GP post, I'm simply stating the fact: if you need state for a building a powerful webapp then obviously there's better runtimes that PHP+Apache, I don't see how one could disagree with that statement, apart from not having sufficient experience in that matter.

There's plenty of good reasons to counterbalance that fact thought, PHP has a very good ecosystem, multiple mature/powerful web frameworks, and cheap/abundant workforce. But it lacks a state holding runtime and for the most demanding applications it's a sufficiently big technical hassle to encourage seeking other runtime and/or language.

Yeah sure, no need for state in a CRUD API. But while it is the most common use case for PHP applications (well actually for application written in scripting languages working with http servers), it's not the only use case.

When the only place where you can put state is the database then every piece of state is written in the database. Which lead to intelligent individuals (no pun/offense intended) to write clever piece of infra such as Redis. The truth is, for 10 Redis deployment there's 7 (8? 6? Well, a substantial part) where a long living process holding little state would have done the trick. Now you need to deploy, maintain and scale Redis too.

OTOH, sometime you need state, then you feel stuck with a half-finished language.

You want a function that accepts a pointer when you want to modify an outside value within a function without returning the value. In that case, the func accepts a pointer (like in `func(p int)`) and you pass it either a pointer (a var declared as an {some_type}) or the address of a variable (with &variable).

And it looks like you've just scratched the surface, you're not finished encountering walls yet.

Hang in there, there's a relative important chance that the fog will clear for you in some months/years.

The hard truth is, software engineering today is made of layers upon layers of abstractions. You have to dig threw those layers, understanding sufficiently the inherent and different complexity of each one before jumping to the next. And then finally it'll make sense, and new layers (there's a new layer every year btw) will be easier to grok.

If it helps, we've all had to go threw this learning process. All of us. However I don't think everyone is made for enjoying this process, that's another hard truth.

The real difficulty is sticking to the learning process while everything and everyone is screaming at you "Go! Build something! Ship Something! Show something you lazy b".

Conflating tobacco induced deaths with covid19 deaths is, for one, a giant big mental shortcut. Then throwing lockdowns in it. And finally ending of a 'mother nature is wounded' note. This is not Reddit guys.