First and foremost: bust mono-cultures in critical IT environments. Meaningful vendor diversity should be mandatory-by-law, and just like in the early days of the Internet, when nobody in their right mind would move into a data center that didn't have at least separate 'Cisco' and 'Juniper' uplink connectivity (so a vendor-specific bug wouldn't wipe you off the net: "ah, that unexpected BGP behavior took down all our peers for several hours" was, like, a weekly occurrence then), we shouldn't accept check-in-counter-workstations running exclusively on Windows today. It's already inexcusable that 'boot into the last OS snapshot that still worked' (which is commercial-off-the-shelf stuff used in most schools, just because 'little Johnny broke the PC again' is just a fact of life there) is apparently beyond oh-so-important mega-corps like Delta, but we need to go further.
So: mandatory hardware switches that select a boot into either Windows (running off one brand of SSD), or Linux or another completely-independent alternative (running on another brand of storage device, so that 'well, today is the day that all Seagate drives refuse to respond, due to an uptime integer overflow' is recoverable). One environment runs Chrome/Edge, Office365-connected-using-that-lovely-propietary-Exchange-protocol, the Microsoft TN3270 emulator and what-have-you. The other Firefox, OpenOffice with Thunderbird-over-IMAPS, Mocha TN3270 -- you get the idea. Run one environment for 3-to-4 days, then a mandatory switch-over, then back again, all year round. The training and making-everything-look-and-work-the-same development efforts will be fun, but nothing insurmountable.
Next up: Clownstrike and cohorts. Much has been made of the fact that custom kernel-mode drivers were used to track system activity, leading to this particular incident, but I can assure you, as a repeat victim of Enterprise Security Solutions, that even in plain old user mode, it's entirely feasible to mess things up beyond recovery using just the programming equivalent of a butter knife. And getting rid of layers like these will just never happen: "simply make the underlying OS secure enough" is not compatible with an open market for general computing, nor with the ambitions of Security Bureaucrats, and there will always be a need for 'zero day mitigation' which, when done reasonably well, can actually have dramatically good outcomes. I see this on a regular basis when figthing email phishing and spam: if you happen to catch a novel attack strategy and block it right away (which often requires an entirely new class of checks), you prevent a significant number of incidents. Snooze for an hour or two, and the (often painful) damage is done. So, "external vendors pushing cutting-edge code to all your devices on a real-time basis" is here to stay, and while certain players of course need to step up their basic validation game, regulation can only do so much.
So, what can be done: force Microsoft to ship https://learn.microsoft.com/en-us/sysinternals/downloads/sys... as a default and supported part of the OS, open-source it, have an industry-leading bug-bounty program, plus provide a rock-solid user-mode API that not only satisfies MS requirements, but also those of accredited third-party vendors. On Linux, where most interesting full-system observability tooling is still proprietary as well, find someone to open-source theirs (hey, Elastic has https://github.com/elastic/ebpf and some related stuff like https://github.com/open-telemetry/opentelemetry-ebpf-profile..., so perhaps that's a good basis?), with pretty much with the same requirements: rock-solid, open to reasonable criticism/improvements and a generally safe interface to whatever observability is deemed to be required.
TL;DR: the time has come for legally-mandated dual-ecosystem critical-use workstations with vendor-agnostic and safe observability APIs. First to deliver wins!