Hacker News Reader

Khelavasteron Why Are Many Indians Fixated with the Purity of Their Bloodline?

Because Indians informally understood. epigenetics for millenia without bridging to formal understanding..

Khelavasteron Stephen Wolfram – 4-Hour Conversational Documentary on My Entire Arc of Life [video]

Wolfram WAS the first set of MacArthur fellows. It counts for something..

Khelavasteron [dead]

This is Show HN

Khelavasteron Salmon Finder

Good to see fairly-priced apps.

Khelavasteron [dead]

Probably he's really dead. Putin tortures people to death in prison through neglect all the time..

Khelavasteron The Timeless Way of Building

Full version: https://archive.org/details/timelesswayofbui0000alex_u9i8

Khelavasteron McDonald's seen with single arch branding

Cost-cutting? 50% fewer arches.

Khelavasteron Dopamine: Everything You Need to Know

Only talks abot dopamine, motivation, and learning. Don't look here for how dopamine controls physical coordination and activity.

Khelavasteron Could Onomatopoeia Be the Origin of Language?

Onomataopoeia are a neurosemantic center of language.

e.g. All language should evolve towards onomataopeaic formulations when all else is equal.

Khelavasteron Ask HN: Books to read to get better at designing software systems?

"A Timeless Way of Building" "Notes on the Synthesis of Form" "On the Nature of Order"

by Christopher Alexander

Khelavasteron Can tin foil hats block anything? (2015)

Yes! Microwave attacks like against international embassy workers are FOILED by aluminum hats.

https://www.nytimes.com/2018/09/01/science/sonic-attack-cuba...

Khelavasteron The Worst Mistake in the History of the Human Race (1999)

By the author of "Guns, Germs and Steel"!

This is sort of eurocentric though -- what about successful Native American agriculture?

Khelavasteron The meathead margin: how lifting weights might have saved my life

Your post is also mistaken. The study tested "In vivo tumor growth...using a tumor xenograft model."

It's humanized tumors in mice with humanized immune systems. Totally a mouse/rat study.

Don't be the guy who misleads researchers and sick people out of deep ignorance.

Khelavasteron The meathead margin: how lifting weights might have saved my life

That's a single in vitro study which represents Lidocaine's well-studied effects on certain kinds of cancers.

Locally-delivered lidocaine to SCC-diseased oral areas and tumorous lymph nodes is totally feasible.

Khelavasteron The meathead margin: how lifting weights might have saved my life

But really, shoot up some Lidocaine/analogues: https://onlinelibrary.wiley.com/doi/10.1111/odi.14819?af=R#:....

(Anticancer role of lidocaine in oral squamous cell carcinoma through IGF2BP2-mediated CAV1 stability)

Khelavasteron Think of dopamine as finite resource to spend on activities

...And this author doesn't realize that enjoyable activities regenerate dopamine. RIP.

Khelavasteron [dead]

I was actually wondering, "how could they have shot themselves in the foot standards-wise by ignoring an XML version, if a JSON version would be first-class?

Khelavasteron Slalom: Designing a runtime for AI-generated code

Slalom Consulting must be excited for the advertising: https://www.slalom.com/

Khelavasteron Pint-Prices: best pints at the best prices across London

No Ayinger in London apparently :(

Khelavasteron Has LA cracked the code for building affordable housing?

Manufactured homebuilders have cracked the code for building affordable housing. Just need to make places with space productive enough..

Khelavasteron A seafood firm wants to farm octopus. Activists say they're too smart for that

Tilapia can be raised vegetarian. Salmon eat meat. Lots of fish can survive on mostly insects and water plants. All depends.

Khelavasteron A seafood firm wants to farm octopus. Activists say they're too smart for that

"ranching" is the right term. Like what we do for lobsters, when we feed and trap them

Khelavasteron John Walker, founder of Autodesk, has died

Walker died walking :(

Khelavasteron The road to hell is paved with asphalt

How does this guy feel about concrete, I wonder...

Khelavasteron What if you just bought everyone air purifiers?

How much lost work productivity comes from air quality issues..?

Khelavasteron Velorum Therapeutics: Powerful cancer drugs that starve tumors (YC W24)

They build off of p53/SIRT heme regulation pathways...

1. Lidocaine seems to treat many cancers via hemeapoptosis and p53 pathway changes this same way, including ovarian & breast and oral SCC malignancies.

(See: "Lidocaine Promoted Ferroptosis by Targeting miR-382-5p /SLC7A11 Axis in Ovarian and Breast Cancer" (2021) -https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8188239/

and

"Anticancer role of lidocaine in oral squamous cell carcinoma through IGF2BP2-mediated CAV1 stability" (2023) -https://pubmed.ncbi.nlm.nih.gov/38071190/)

===

2. Velorum Therapeutics should explicitly promote p53 pathway more. Many cellular experts still don't implicitly associate p53 (and SIRT + nk-fb) with heme metabolism.

Khelavasteron How to last longer in the cold plunge

Take this guy's advice headfirst and get hypothermia if your constitution isn't as strong as his..

Khelavasteron It's the hope that kills you

"Social media icons without descriptive text?" Actually very important for people. who don't know what the icons are."Footers without sufficient color contrast"? Nice to be able to see built-in footer navigation.

Khelavasteron I know languages that have support for "read-only memory," but what about "writ

Output devices. He's talking about printers and monitors.

Khelavasteron Molly's Game movie review and film summary (2017)

Fantastic movie. Love it.

Interestingly--It was produced with Molly's input while Molly was facing charges. A very exonerating angle.