BlakePetersen

For what it's worth, I just recently upgraded from Nexus 5 to Nexus 6 and I have had absolutely no problems with the device, especially with call volume. Literally everything is a step up.

I wouldn't let this sour you entirely, if your device has a problem, return it for a new one. I had an issue with my Play-store-purchased Nexus 4's earphone jack, prolly my fault, Google replaced it within a few days, paid for shipping and everything.

There are a lot of business decisions that go into applying resources to problems, and we can't all assume we know those business decisions and the circumstances that are involved with making them. This could be a very small but vocal segment of the nexus 6 user-base, if it is a small problem, it should be treated as small priority.

Personally, as a type-1 diabetic, it sucks seeing research done specifically for type-2 diabetes, but, unfortunately there are less of us, so it's seen as a lower priority.

What's not mentioned here is California just broke ground on a similar project from "LA to SF" but is more like Burbank to San Jose. It is not only estimated to cost 10x as much, but because it will use existing Amtrak rails not designed for high-speed trains, it will never meet the legal requirement of getting from LA proper to SF proper in 2:40.

Can someone please introduce Gerry Brown to Elon?

As a type 1 diabetic, fasting for 20 to 30 days would likely kill me.

Stop making blanket statements.

It's offensive that you are perpetuating the false belief that all diabetics can fix their problems by simply fasting.

>> "20 or 30 days without food will resolve most symptoms in most humans."

If you are a type 2, you are a diabetic due to lifestyle choices like overeating, eating/drinking high-carb foods, not excercising, smoking, etc. If you are a type 1, no matter how good you eat, you will still need to take subcutaneous injections every day to manage blood sugar, your body won't let your pancreas create insulin or glucagon.

For type 1s, this is terrible advice. It won't help and will likely kill you.

For type 2s, this is somewhat sound advice. While I don't imagine too many type 2s who have the discipline necessary to not do that which they have overdone for years for 20 to 30 days, a type 2 eating a lot less (or perhaps fasting entirely under doctor's supervision), it will definitely help better the situation and would be a great step in getting their diabetes under control.

What I find frustrating is that this research is being done for the section of diabetics who actually have control over their diabetic destiny, simply stop being obese by any means necessary. As a type 1, I honestly resent Type 2s who do nothing to better their situation. This research is just another way for Type 2s to not have to deal with the consequences of their actions ahead of me and those like me being liberated from our sharps, glucose monitors and pumps.

Wow, I am raging, better check my levels ;]

Bummer, data ends right before last major storms rolled in. I would like to see how this data has changed over the course of the last week.

I'd imagine the patents are owned by the institutions the research is being conducted at and a Big Pharma will company will buy or license those patents after trials.

Startups are too small for shouldering the financial load of developing/testing/insurance/lab facilities/high end staff. Plus, Big Pharma has established distribution channels that would get a Type 1 like me my cure faster, which one may consider ethical territory.

This is pretty spot on.

You generally always have a running estimate in your head, "I ate two tacos, took three units of Humolog, needed to correct down an extra 50 points with the extra unit (because I undershot last meal), etc."

But there are factors that you have a more difficult time predicting your levels with, like exercise, illness, the type of carb your eating (some carbs take longer than others to hit your system, but if you treat all the same, you insulin will hit you faster than your carbs and you're now hypoglycemic).

Truly staying on top of your numbers and this disease means constantly checking. You can always make a guess, but when the risk of serious short-term and long-term complications hang in the balance, you tend to want to know for sure.

Without insurance, blood glucose test strips cost $40 for 25. I test myself 8 times a day. That's nearly $5k/yr right there. It is really expensive... Thank God for health insurance

This is a HUGE breakthrough.

Not only are islet cells able to be mass produced (one transplant means 150 million cells need to be created), but the challenge of the body not simply killing off these cells too through the device created at MIT really seals the deal.

Without the implatable device, this would not be as big of a breakthrough, but having both the challenge of mass producing these cells and ensuring they are able to survive after transplant without use of immunosuppressive drugs (read hardcore side effects) effectively solved makes this a real, viable solution to this problem.

I disagree. The fact they can now mass produce insulin producing islets and have a mechanism of ensuring the immune system doesn't attack them means it's very likely to be a long term cure.

The mice they have been testing have maintained their glucose at human levels for months (they generally run 60-80 points higher than humans). They've binged and fasted them, made them sick and everything and their levels have maintained.

This is definitely promising, don't be such a wet blanket before researching a little bit!

I am Type 1 Diabetic. I have done some research, but am by no means an expert.

1. Yes 2. No. "Melton said that the device Anderson and his colleagues at Massachusetts Institute of Technology are testing has thus far protected beta cells implanted in mice from immune attack for many months. “They are still producing insulin,” Melton said."

There are two breakthroughs. The mass production AND the ability of the device to protect the cells from destruction.

3. Yes. It reacts ideally in pretty much all scenarios. When you eat, it produces insulin. When you fast, it doesn't lower you into hypoglycemia. When you're sick (like a cold) it regulates insulin as it should, as your body needs more or less as your insulin sensitivity is off.

This is definitely HUGE!

https://github.com/SMLFamily/The-Definition-of-Standard-ML-R... in case anyone else is hitting the GoDaddy landing page...

If it's 'brand new', there shouldn't be too much disparity between the recovery and your current state.

This is pretty awesome stuff! I'd love to tinker with it and it sounds like a few others would like to as well. Do you have any plans to open source this?

Yea... this argument started to go south as soon as I realized it was 5pm. Surprised it is only at 0 TBH

There's another option, root and load a custom Rom. Not only will the phone run leaner (and in theory faster) but it won't have the bloat. The only investment is your time. =]

These restrictions would stymie innovation as well as take the devices out of the hands of the less-affluent, no bueno.

Bloatware has some good it brings, this good just doesn't have an affect on me.

Similar to taxes, I pay a ton of them and don't really get anything back aside from so-so roads. Where someone who is in a bit worse spot sees a lot of benefits from those taxes. It's something I accept as necessary, but I still do everything I can to keep them as low as possible.

But I don't go around blaming the Federal gov't because California taxes me higher than Washington would. Instead of proposing the feds restrict what can and can't be taxed, I could just move to Washington. The choice is mine! FREEDOM FTW! ;P

So one needs a computer with iTunes installed to update an iOS device? It doesn't do it over the air?

Also, the "update shit show" reference was toward the software that was updated, not the update process itself, regardless of the hardware/software needed to pull it off.

Source for the downvoters: http://www.usatoday.com/story/tech/2013/10/17/apple-ios-7-pr...

Silent Circle released the Blackphone it developed off a fork of Android. This policy has allowed for bloatware, yes, but it also allows for innovators to innovate unimpeded.

I have the choice to buy a phone without bloatware and I did. I don't know why others don't do the same and then blame the OS maker for allowing their open software to be open.

These policies also allow for cheaper phones to get into the hands of the less affluent. Not everyone can afford the new iPhone, and they would rather have a phone with a bit more bloatware if it cuts the cost of the phone down to something they can reasonably afford. I would consider that a noble endeavor on the part of Google. Instead of saying, "FUCK YOU CARRIERS/OEMS, YOU DO AS WE SAY!", it offered them a means of providing cheaper phones without decimating their bottom line. They can choose to strip out all the bloat and price it high or they can bloat it up and price it low, making up the cost from the recurring fees/ad rev those apps can generate.

The thing is, I have a choice as to what experience I want.

Google doesn't cause bloatware, Carriers and Handset makers do. One of the many consequences of OSS, people can fork and bloat to their heart's content.

Also, I haven't had one issue with software updates on my Nexus 5 (which indeed comes bloatware free). If I recall correctly, wasn't the iOS7 update a shit show?

Usage limit exceeded? Well there's your first issue.

Hacker news will ruin me. I've checked HN three times since sitting down 45 minutes ago. I don't even have a file open yet, I am literally staring at my home folder on my right monitor. My HN addiction has literally caused me to take 45 minutes to open Nautilus.

Paying for jQ bandwidth is like paying for air, seriously.

With jQ, you're most likely defining the version you need, so getting upstream improvements with jQ is a bit more involved than the library simply updating itself if you aren't using the edge version.

A better argument for using a CDN is that jQ library is likely going to be cached if the user's been on the web for more than 5 minutes. Chances are, your version will be one that's cached and, instead of waiting for the downloading of a library that already exists on the users system, the library is immediately loaded and perceived PLT is decreased as a result.

There are also numerous CDNs out there, I would use a fallback stack to ping the next CDN in line as it would be a cold day if every major CDN that hosts jQ were to lose SSL support for a time.

Watch out for the whole double taxation issue. You will need to pay taxes to the US (there's a certain income threshold if I remember correctly, but you'd likely surpass it). If you wind up taking permanent residency, you may need to renounce your US citizenship to stop having to owe taxes Stateside.

(http://www.irs.gov/Individuals/International-Taxpayers/U.S.-...) -- "Your worldwide income is subject to U.S. income tax, regardless of where you reside."

Then get off HN! You got bugs to fix!

It looks like this is purely for personal use. Is there any sort of collaboration or cross-device syncing available or in the roadmap? Or is this intended to be more-or-less silo'd per machine?

Exactly what I was thinking. What is the value of removing medium articles from HN/DN?

As someone who seems to have a lot of insight into this, to the best of your knowledge, could you speak to what factors would most heavily influence this decision (in the context of being made by a founder in Seattle)?

Was MS never even in the running or could it possibly boil down to the cost issue I touched on or perhaps that founders or early engineers chose a different route due to past personal exposure (and would you feel that the financial barrier of entry is a factor in limiting these engineers to this MS software exposure)?

Would have a bit of incentives from MS like reduced license costs steered those early conversations in a different direction or is it simply that the software they offer isn't up to snuff with your particular use cases?

Thanks for the feedback, that definitely seems like the consensus.