The efficacy of all this depends on having a rock-solid chain-of-custody for the blood samples-- just like evidence used for a criminal court. Not easy.
Proof is the "alleged" steroid use of Ryan Braun - the Major League Baseball case where the guy in charge of the sample left it in his home over the weekend and Braun got off on this technicality
For the purposes of a drug test, your requirements are even looser. I don't see why you'd need or care about lysing your cells. A test is only going to be screening for small molecules, so destroying organelles and lysing cells should be largely irrelevant.
AFAIK, even flash frozen and gently thawed prokaryotes do not have 100% survive rate and eukaryote survive rate is considerably lower. My comment revolves around the idea that biochemical reactions have pretty strict requirements on conditions for happening at all, while chemical reactions are much looser in this regard. Even 99.999% survivability calls for scientific research on structural/biochemical/chemical change prior to using such techniques for anything touching legal system with anything shorter than ten foot pole. IMHO. Happy to be corrected.
The scary thing is had Armstrong not tried to come back to cycling the last time he would've been in the clear. The reason Landis turned him in was Armstrong refused to let him on his team.
Which reminds me: Mr. Landis still owes me $35 for that book of his that I bought. [0] His book did highlight what an unprofessional ass Dick Pound (head of WADA at the time) is, and how loosy-goosy some of the testing was. But in the end, Floyd doped just like the rest of them and deserved to be stripped of his TdF title. Once Landis' story broke, I can say that's the point at which I just gave up on pro cycling. That's when it all became clear that cheating also includes lots of lying, and regrets only come when they're caught. I gave the whole lot the benefit of the doubt, and now feel foolish for doing so. I'm a former Cat 2 racer, USAC race official, paid loads of money for pay-per-view races, loads of money on gear; now I don't do any of it, and if I watch sports on TV it's MotoGP. Sports participation is now trail running, where the most insidious drug I see evidence of is the cloud of pot smoke rolling out of some dude's car right before the start.
If Armstrong had just left well enough alone, as you mention, he would have walked away a hero. But I'm guessing his cockiness caught up with him, and he just didn't know when to leave well enough alone, convinced that if he hadn't been caught before he'd continue to not get caught. Which seems to be the downfall of many criminals that get caught.
And as unprofessional as Dick Pound's behavior might have been, it turns out he was right. That's where I'm conflicted. Not "innocent until proven guilty", but "I'm convinced you're guilty, and whether you're guilty or not I'm going to dig until I find dirt". But he was right, at least this time.