Besides all the research pointing to that fact, I myself has burned myself into smitherines from stress and a toxic working enviroment. It took me two (2) years after my burnout to be able to work more than 2-3 hours a day and 4-5 years before I could work 8 hours a day for a week!
The brain is plastic, this means that it changes from stress and once you have overloaded it, it becomes more sensitive!
It's like breaking a bone - even though it grows back together, it will always be weaker.