I stayed 250 nights in a hotel for work last calendar year. ~220 in SPG, ~25 in Hyatt (enough to earn Diamond status), ~5 in a Marriott because there were no other options.
Although I was at full liberty to do so (and expense it), I never chose to stay in an AirBnb. To make this feasible for me, I think AirBnb would need several things:
* Some sort of loyalty program with PERSONAL benefits to me - this would best manifest itself as a credit in my personal account
* Status - SPG Platinum greatly enhanced my traveling experience with perks such as recognition on check-in, upgrades, gift baskets, etc. I didn't care about most of this, but AirBnb could certainly implement aspects such as "upgrades" to nicer/bigger properties which are vacant within an x-block radius, gift baskets (delivered by the likes of Postmates, UberEATS, etc.), local events, etc.
* Instant booking - this is HUGE. I very very often would book hotels past 6pm on the night of, or move/cancel stays based on work, airline schedules, etc. I don't want to wait to interact with a host - I just want a key.
* Amenities - Fast WiFi is a must, outlets by the bed are nice, and very important - gym access. No reason why AirBnb couldn't come up with an arrangement with e.g. 24 Hour Fitness to provide access passes to guests
* Room service - Partnership with Postmates/Caviar/DoorDash/etc. to bill directly to room, along with a preview of what's available
* Personal concierge - ala SPG Ambassador
* Perhaps most crucial to this list, is a concern for the employer, not me - the reason Amex/Concur have a duopoly over the enterprise travel market is not because of their partnerships or UI - it's because they offer integration with HR systems for things like emergency alerts (e.g there's been a terrorist attack in NYC - I need to know which of my employees are staying in a hotel near xxx). AirBnb should already be in talks with Workday/Zenefits/ZenPayroll and the likes to figure this out for tech startups - most likely to be early adopters.
AirBnb has a potenitally superior product as compared to SPG,Hyatt,etc. and a better interface than Amex/Hipmunk/Concur/Orbitz for Business. But corp travel is complicated, and customers are extremely finicky. Huge potential to get this right, huge opportunity if they do.