But seriously, in my case, I'm determined to never become an insulin-dependent diabetic. I was over 340 lbs. 16 years ago (and believe it or not, I was not a big eater compared to male peers), then I read about low-carbohydrate eating strategies, and had slow but significant success (lost over 120 lbs in a 20-month span).
But getting back to the question: my motivators were/are: 1) appearance 2) staving off degenerative disease (diabetes, heart disease, etc.) 3) activity enjoyment (e.g. hiking, volleyball, etc... weight is a limiting factor and contributes to injury)
My biggest problem is maintaining a regimen when I am not getting results. This is how I derailed in the first place in my late 20s -- despite running 4-6 miles 2-3 times a week, I couldn't lose an ounce.
Also, keep up on current science: for example, you could expend a lot of effort doing something that isn't that helpful if you a part of the population that is a low genetic responder to cardio (see the University of Bath study as covered in Michael Mosley's "The Truth About Exercise" on PBS). In my case, I also exhibit the classic symptoms of AD-36 exposure, so I have a tougher row to hoe.
The hard part is getting it right for you. I like to run and I've run my whole life so exercise was never an issue, guess I lucked out there. I've tried going to a gym many times and it just is not for me, for example.
Whereas it took until my 50s to figure out that a low-carb diet was right for me. Before I had a terrible sweet tooth, but now you couldn't pay me to eat sugar.
So my advice is to try lots of things without getting hung up on the dogma associated with each, until you find the things that click.
Eating healthy: remove everything you shouldn't eat from your home and only eat food out of your home. Eat Soylent for one meal a day.
In actual fact, I tend to run about 2-3 pounds above my target, but I take stronger action above that.