Finnish study: Smoking and drinking coffee might prevent Parkinson's disease
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> Deprenyl protects the nigrostriatal dopaminergic neurons against selective neurotoxins (6-hydroxydopamine, MPTP, DSP-4) [2]
We know that environmental insults like solvent inhalation and most likely agricultural pesticides contribute to the loss of dopamine neurons in Parkinson's, it seems like Deprenyl has the ability to protect against the damage of some of these, as well as the effect of aging [3].
> These results suggest that (-)-deprenyl and related compounds may protect neurons from apoptosis and be applicable to delay the deterioration of neurons during advancing ageing and in neurodegenerative disorders. [3]
I myself take deprenyl, or its newer cousin azilect for this purpose. It also has the benefit of increasing dopamine and it's a much lower impact focus drug than psychostimulants like amphetamines.
[1] http://www.ncbi.nlm.nih.gov/pubmed/3123604
I am 30.
Update because I can't reply re: self-experimenting:
Deprenyl is an incredibly well researched molecule, with a great safety profile. We also have a lot of reason to suspect amphetamines like adderall are neurotoxic to dopamine neurons, and hence my fervent belief that deprenyl should be a first line treatment for those wishing for enhanced focus, and amphetamines should be reserved for tougher cases.
My dad has submitted data to 23andMe as well, but unfortunately it didn't come with a free account. It was a special thing they were doing to collect Parkinson's data. So I have no idea if he has the markers.
I have a very strong belief that Parkinson's will be completely cured by the time I could be at risk. It has been completely reversed in several animals with the use of a few different types of stem cells.
I have also gotten my hands on a brand new neurogenic small-molecule drug called NSI-189 that is currently undergoing clinical trials.
Originally commissioned by DARPA to create the war figher of the future, NSI-189 has shown a robust effect in triggering hippocampal stem cells to regrow the hippocampus.
I've ingested about 5 grams and its had a tremendously positive effect on me.
What has NSI-189 done for you specifically and how does it make you feel? Are there any annoying side effects and where in the heck did you get it?
NSI made me feel like a kid again. Brought me back to 100%. Stress is really, really bad for our brains, particularly our hippocampus.
No side effects for me.
I got it through back channels, can't say anymore and risk the pipeline.
It will be on the market in five years and will in my opinion revolutionize the treatment of depression, ptsd and other neurodegenerative disorders.
Curious what medications you were taking?
30-40 years is a lot of time for research.
Andy Grove is another famous person with the disease who's working hard to find treatments:
And prevention is much cheaper than cure.
Personally, I'd probably wait until my early 50's. Hopefully, at the very least, in 20 years, they'll be able to detect and monitor the effects on the body with more precision.
At the very least, billions more in research will have been done.
https://www.youtube.com/watch?v=EDhpcOJ2zzM
If you go back 40 years, the MRI wasn't even invented. In fact, there wasn't an Apple computer. The PC revolution was a few years away.
A lot will change in 30 years. Whether we're 10 years from the singularity, perhaps not, but technology is increasing at a more rapid pace.
"What neuropathy is, is your nerve cells are starting to die. And it can occur in different places with different symptoms depending on what cells are dying. Things like, for example, Alzheimers is an obvious example of nerve cell death. Things like ALS. Things like Parkinsons disease. These are just all different formats, different disease states, that result from nerves dying. And our endocannabinoid system plays a very unique role in trying to protect us from various kinds of nerve cell death.
So what's going on with the endocannabinoid system is that it's something that protects our nerves in general. It helps promote nerve growth and nerve health, and rewiring of your brain. You know, adults up until the fairly recent past, it was believed that we no longer had the capacity to regenerate nerves. And what we now know is that we do have that capacity, but furthermore what we know is that nerve regeneration in the brain is very much regulated by these marijuana-like compounds, these endocannabinoids. So we have a whole host of very important activities, the direct protection of nerves from dying, the promotion of regeneration, the promotion of learning, of re-learning things, is a very important biological effect of our endocannabinoid system.
So what are the kinds of things we can do to try and promote health in these areas? On the one hand, everybody should make sure they take in enough essential fatty acids. And certainly I would say one of the best sources for that is we should be consuming hemp oil. And the reason I say hemp oil as opposed to fish oil is because you can ensure organic hemp oil is not contaminated with things like mercury. And that's going to allow our bodies to make our endocannabinoids.
We often hear about the beneficial effects of things like Omega-3s and Omega-6s, and at least some of the attributes of those compounds are the result of them being converted into endocannabinoids. So at least that way your body can do what your body can do. You're giving it the tools to make the things that you need. But in many cases, that's not sufficient, and we have to supplement beyond what our body can make. And there's only one plant on the planet that has the capacity to mimic the way our body works with these endocannabinoids, and that's marijuana.
So marijuana actually directly mimics these particular compounds, and as a result, it has these strong neuroprotectant effects. But because marijuana and these endocannabinoids, their activities are so pervasive in our bodies, they literally regulate every system in your body, your immune system, digestive system, reproductive system, cardiovascular system. Everything in your body is homeostatically maintained by endocannabinoids, meaning balance. They're how our body tries to balance how we interact with the environment when our environment becomes stressful for us, stressful psychologically, stressful biochemically. So these are very, very critical compounds and the use of cannabis can have a profound effect in terms of helping to stop nerve cell degeneration, helping restore functional nerves, helping restore new ways of thinking. And this is just really touching on the surface of the humongous number of benefits that this plant can have for so many different illnesses.
... and what our cannabinoids system is evolved to do over many hundreds of millions of years has been to protect us from those kinds of inbalances. To restore the kind of health that we need. And because of our environment, in particular because we are living longer, we need to be able to adapt very rapidly today, and we can't do that on an evolutionary scale. The way for us to do that as people, as intelligent people, is to make sure we're eating good diets, stay away from toxins, and eat these essential fatty acids, and when necessary, consume cannabinoids."
- Dr. Bob Melamed, Ph.D., UC Colorado Springs
http://www.uccs.edu/rmelamed/endocannabinoids-and-medical-ma...
Have long term effects of that been researched? I mean, is it healthy to constantly (or however the effects last) and for multiple years have higher dopamine levels than what is natural for a person? Would you still notice the increase in dopamine after years, or would it then be the 'new' normal level?
" Objective: To assess whether being able to quit smoking is an early marker of Parkinson disease (PD) onset rather than tobacco being “neuroprotective,” we analyzed information about ease of quitting and nicotine substitute use.
Methods: For this case-control study, we identified 1,808 patients with PD diagnosed between 1996 and 2009 from Danish registries, matched 1,876 population controls on sex and year of birth, and collected lifestyle information. We estimated odds ratios and 95% confidence intervals with logistic regression adjusting for matching factors and confounders.
Results: Fewer patients with PD than controls ever established a smoking habit. Among former smokers, those with greater difficulty quitting or using nicotine substitutes were less likely to develop PD, with the risk being lowest among those reporting “extremely difficult to quit” compared with “easy to quit.” Nicotine substitute usage was strongly associated with quitting difficulty and duration of smoking, i.e., most strongly among current smokers, followed by former smokers who had used nicotine substitutes, and less strongly among former smokers who never used substitutes.
Conclusions: Our data support the notion that patients with PD are able to quit smoking more easily than controls. These findings are compatible with a decreased responsiveness to nicotine during the prodromal phase of PD. We propose that ease of smoking cessation is an aspect of premanifest PD similar to olfactory dysfunction, REM sleep disorders, or constipation and suggests that the apparent “neuroprotective” effect of smoking observed in epidemiologic studies is due to reverse causation.
"
http://www.neurology.org/content/early/2014/09/12/WNL.000000...
source: http://www.parkinson.org/Parkinson-s-Disease/Young-Onset-Par...
ah, yeah, here it is: http://www.ncbi.nlm.nih.gov/pubmed/8437692
Half of my extended family completely ignored the part on "The 'dose-response' pattern showed the greatest risk reduction among those who smoked least" (if it ever got mentioned at all), and used it as an excuse to keep smoking for, well, as long as it took for everyone to forget the meme and go back to smoking Because Freedums!
Ok, nevermind, I guess they never needed an excuse to begin with.
Dopamine.
Anecdotal, I know :)