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I also think it has to happen on the web (open or closed), instead of the desktop software.

Also, d3 wont be able to pull it off. If we do a comparison, i think that d3 is MooTools, wee need to get to ES6/angular/react kind of libraries.

What do you feel that ES6/Angular/React do that d3 won't? They are for building user interfaces. d3 is for charting.

(Most bioinformaticians I know seem to use R).

It was a comparison. Once MooTools was the library to use, now its dead.

Why do you think it has to be web-based?

- collaboration (easier than desktop, but still possible there)

- instant updates and critical bug fixes

- reproducibility

- visibility

also, because of "Atwood's Law" [1]