Yes it will,if you do 5 grams a day - which is a ridiculous amount. If you are doing that much, you might in fact be a horse.
https://en.wikipedia.org/wiki/Ketamine#Urinary_tract_effects
https://en.wikipedia.org/wiki/Ketamine#Urinary_tract_effects
That only implies that if you do 5g/day, you will with near certainty get urinary tract problems. You can definitely get get urinary tract problems with much lower dosages.
Legitimately manufactured ketamine is typically in sterile saline solution at a fixed quantity per dose. This is because the usual medical route of administration is intra-muscular or intravenous injection.
For recreational use, (afaik) the majority is insufflated, or snorted. For this you need the dry, crystallised form.
You can either purchase it as crystal from your friendly neighbourhood drug dealer, or they may be able to supply you with vials diverted from veterinary or medical suppliers. To get this to a powder, you boil off the water "Cooking" and are left with a mixture of ketamine and salt.
The 2 biggest problems are trying to either rehydrate crystal powder for injection (because ensuring sterility and consistent dosage is hard), and that crystals are much easier to cut with other ingredients (because the legit. vials usually have tamperproof seals like other legitimate drugs).
The other point is that most people won't be injecting it right from the beginning. Only once they become tolerant and require high doses does the appeal of IM/IV's increased 'efficiency' (bioavailability) tend to override the common wisdom of not sticking needles in oneself.
From what I recall, most of the research has shown that long-term administration of high doses is where the damage is predominantly done, and even very high doses (1000mg would be a plausible dose for 'short term surgical anesthesia (15-25 mins) of an 80kg adult), if given very rarely, are not likely to cause harm.
But injecting that sort of quantity, multiple times a day, for weeks or months, is absolutely going to lead to problems, and even more of them if you're getting impurities or bacteria/spores along due to contamination.
I might have my terminology mixed up, but there is definitely a difference between crystallised and that which has been cooked (possibly again). Some of it might possibly be myth on there behalf, as in they don't get as bad a "k belly" or irritated bladder after a binge on the latter.
As well as the bladder/ut issues, snorting (anything) also leads to the corrosion of the septum and also the bone(s) that supports teeth.. Basically excessive use leads to teeth falling out.