We would be venturing into genetic engineering to breed "space humans", which is at least problematic.
Here in the USA, currently trans fats are killing people. Some people can tolerate trans fats more than other people can. We evolve to tolerate them.
The same goes for every other not-good-for-you kind of thing we eat. People who tolerate it (or find it nauseating) will survive longer.
Now that many do survive to old age, natural selection can work to eliminate menopause. Today there are those who hit it at 30 and others who hit it at 50 or even later. Some leave more offspring, and this is all that is needed to drive natural selection. We evolve, and always will.
For example, for millions of years our bodies have become adept at precisely the amount of gravity Earth pulls on our bodies. Whether or not that has affected the species ability to reproduce, or if it's consequential to our ability to live comfortably in space, is another question, but I feel there are more ways evolution has affected our genes (to be more perfectly adapted to Earth's environment) than we may realize.