The usual counter is that "optimising" takes time. And all of the time that you're spending trying to optimise before release is time that no one is able to use your software at all.
And the reality is that a lot of the bottlenecks can't be predicted in advance - who knows how may files the average user might want to load into your system, or whether your website is going to attract 100 or a million users a month? And many expected bottlenecks become largely irrelevant as technology moves on.
Take his Ubuntu example - for what percentage of users does the fact that it doesn't fit on an actual CD really matter any more? Is it worth spending weeks or months fine-tuning the distro to a point that it can be fitted onto a medium that most people probably aren't even using anymore?