Water Fluoridation May Not Prevent Cavities, Scientific Review Shows
newsweek.com
newsweek.com
> Studies that attest to the effectiveness of fluoridation were generally done before the widespread usage of fluoride-containing dental products like rinses and toothpastes in the 1970s and later, according to the recent Cochrane study. So while it may have once made sense to add fluoride to water, it no longer appears to be necessary or useful, Thiessen says.
> It has also become clear in the last 15 years that fluoride primarily acts topically, according to the CDC. It reacts with the surface of the tooth enamel, making it more resistant to acids excreted by bacteria. Thus, there's no good reason to swallow fluoride and subject every tissue of your body to it, Thiessen says.
> Another 2009 review by the Cochrane group clearly shows that fluoride toothpaste prevents cavities.
Late edit;
Here's a look at toothbrushing frequency in Europe by country from 1994 - 2010:
http://i.imgur.com/VVBldAy.jpg
Just imagine how much improvement you'd see from if the chart started in the 1940's and 1950's when many cities began fluoridating their water supplies. Not to mention that many early toothpastes were often ineffective at preventing cavities by primarily relying on baking soda and peroxide.
(Full brushing frequency study: http://eurpub.oxfordjournals.org/content/25/suppl_2/20 )
same time they started water fluoridation the population also started to pay attention to brushing their teeth. or do you think the govt took the initiative at any point in history?
The "Plain language summary" from the authors - their words, so this is the authors of the study synthesizing their conclusions for a lay audience - is clear:
Data suggest that the introduction of water fluoridation resulted in a 35% reduction in decayed, missing or filled baby teeth and a 26% reduction in decayed, missing or filled permanent teeth. It also increased the percentage of children with no decay by 15%. Although these results indicate that water fluoridation is effective at reducing levels of tooth decay in children's baby and permanent teeth, the applicability of the results to current lifestyles is unclear because the majority of the studies were conducted before fluoride toothpastes and the other preventative meaures were widely used in many communities around the world.
There was insufficient information available to find out whether the introduction of a water fluoridation programme changed existing differences in tooth decay across socioeconomic groups.
There was insufficient information available to understand the effect of stopping water fluoridation programmes on tooth decay.
No studies met the review’s inclusion criteria that investigated the effectiveness of water fluoridation for preventing tooth decay in adults, rather than children.
This is from http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD010856.... Thanks to HN user giarc (https://news.ycombinator.com/item?id=9807427) for pointing it out.
And apparently more of it the better. There are even benefits of using stronger fluoride concentrations than just regular toothpaste's 1400-1450 ppm. Humble old fluoride seems to work better than fancy calcium sodium phosphosilicate (also known as NovaMin):
"The purpose of this in vitro study was to evaluate the effect of toothpastes containing sodium fluoride in different concentrations or a calcium sodium phosphosilicate system on pre-softened dentin demineralization and remineralization.
Under these experimental conditions, the high fluoride toothpastes promoted remineralization and inhibited demineralization more effectively, than the 1450 ppm F, the non-fluoridated (control) and the calcium sodium phosphosilicate toothpastes."
http://www.ncbi.nlm.nih.gov/pubmed/20546825
https://en.wikipedia.org/wiki/NovaMin
There are special high-fluoride gels used by dentists / dental hygienists / can be bought in pharmacies; they can help a lot if you have sensitive teeth.
This agrees well with a personal observation of mine. A majority of those I know who grew up in the 1970's or earlier have a mouth full of fillings. Yet almost everyone I know who grew up in the 1990's or later have few or zero fillings.
I've asked several different dentists about this observation. The dentists agree with my observation but they reflexively attribute it to fluoridation of water. But fluoridation began in my area in the 1960's (I checked). The dentists are wrong about fluoridation explaining the difference between '70s kids and '90s kids.
If we were to assume that toothpaste commonly began to contain fluoride after the mid or late 1970's, that would be consistent with a decline in cavities.
Not sure, but that sounds wrong according to wikipedia:
> Fluoride was first added to toothpastes in the 1890s. "Tanagra", containing calcium fluoride as the active ingredient, was sold by Karl F. Toellner Company, of Bremen, Germany, based upon the early work of chemist Albert Deninger.[31] An analogous invention by Roy Cross, of Kansas City, Mo., was initially criticized by the American Dental Association (ADA) in 1937. Fluoride toothpastes developed in the 1950s received the ADA's approval. To develop the first ADA-approved fluoride toothpaste, Procter & Gamble started a research program in the early 1940s. In 1950, Procter & Gamble developed a joint research project team headed by Dr. Joseph Muhler at Indiana University to study new toothpaste with fluoride. In 1955, Procter & Gamble's Crest launched its first clinically proven fluoride-containing toothpaste. On August 1, 1960, the ADA reported that "Crest has been shown to be an effective anticavity (decay preventative) dentifrice that can be of significant value when used in a conscientiously applied program of oral hygiene and regular professional care."
The important thing to note here is that this review is looking for the impacts of fluoridation since the 1970s. The evidence remains clear that fluoridation is better than nothing at preventing cavities! The question at hand is whether it's still important now that we have widespread adoption of fluoride toothpaste.
This Cochrane study concludes, as many Cochrane reviews do, that there's not yet enough high quality evidence to answer this question.
The takeaway here shouldn't be the absurd headline that "fluoridation may not prevent cavities," it should be "we should study how effective fluoridation is now that we have added other successful interventions."
My cat has never brushed her teeth, and they're fine, presumably because the microbiome in her mouth is in a state where bacteria that secrete lactic acid are crowded out by benign species. Granted, she doesn't eat many simple sugars, but I have had a vet recommend brushing her teeth twice a day as a preventative measure, which blew my mind.
I hope I live to see the day when the extent of oral hygiene maintenance and bad breath prevention is a toothpick and an occasional probiotic mouthwash or something.
Personally, I used them for two months as directed, and saw no real difference.
Can't wait for a real product, I just hope it doesn't start off costing $200/month like some probiotics I've seen.
I used mouthwash daily for a few years, established a baseline of how my mouth felt, and how my wife said it smelt. Used the tablet for 2 months, and felt no different, and she said I smelled no different.
It doesn't establish that Evora probiotics are useless, but I think it fairly establishes that they're not significantly better than just using mouthwash.
They raised a $60M Series D in March of last year.
http://www.fiercebiotech.com/press-releases/c3-jian-closes-6...
They completed a Phase II clinical trial last Fall where they tested it as a mouthwash and a gel with three methods of application (tray, electric toothbrush, and manual toothbrush). Apparently gel in a tray won: 90% reduction in S. mutans population that lasted seven days after treatment ended.
http://globenewswire.com/news-release/2014/09/09/664615/1009...
C16G2 is the peptide that targets S. mutans. I suppose the idea is to develop more peptides targeting other species and give you a gel cocktail treatment (or maybe suppressing S. mutans is enough).
Being able to selectively kill exact species of bacteria ... that seems like a big deal.
"C16G2 works very rapidly in vitro with a unique membrane-active mechanism of action. This physical method of killing is not targeting a single gene product, and therefore single gene mutations are unlikely to confer resistance. Also, mechanism of action, route of administration and clearance of the drug are expected to limit drug exposure to the oral mucosa, so no impact on the development of resistance in other bacteria is expected, in contrast to concerns about overuse of traditional antibiotics. Despite believing resistance is not likely, we will carefully monitor resistance in clinical trials and in laboratory experiments."
http://www.c3-jian.com/technologies/frequently-asked-questio...
Okay so house cats don't live that long.. but look at longer living mammals like horses. Their teeth are terrible at 20 years old.
I think the human teeth will do fine without brushing for 20-30 years, enough to make babies. They aren't really designed for the 75 year life plan..
Admittedly, I hate taking care of my teeth and thinking about things this way comforts me when I fail to do so.
Which is not to moralize about your own dental hygiene. Dealing with the consequences of poor dental hygiene is what dentists are for. :)
What if you could do it now mostly with the right diet?
[link] http://www.cochrane.org/CD002278/ORAL_fluoride-toothpastes-f...
"Tooth decay (dental caries) is painful, expensive to treat and can sometimes lead to serious damage to teeth. Fluoride is a mineral that prevents tooth decay. The review of trials found that children aged 5 to 16 years who used a fluoridated toothpaste had fewer decayed, missing and filled permanent teeth after three years (regardless of whether their drinking water was fluoridated). Twice a day use increases the benefit."
https://www.sciencebasedmedicine.org/of-sbm-and-ebm-redux-pa...
They are very clear in the paper that they are reviewing a certain body of studies, and that there are other plausible reasons (not backed up by RCTs) to believe water fluoridation could have beneficial effects. The numbers they quote summarize the evidential content of the RCTs. I don't need or want them to bundle this all into one Bayesian percentage. This would be dominated by their own priors which I do not necessary share nor are necessary shared by anyone I discuss the study with. (Yet we can all agree on the frequentist summary of the RCTs.)
I think you understood this, but I wanted to clarify for others: the Cochrane review that this article is about showed that fluoridated water may not prevent tooth decay. The 2009 review you mention does not contradict this, since it is about fluoridated toothpaste, not water.
"The separate meta-analyses of fluoride gel or mouthrinse combined with toothpaste versus toothpaste alone favour the combined regimens, but differences were not statistically significant; the significant difference in favour of the combined use of fluoride varnish and toothpaste accrues from a very small trial and appears likely to be a spurious result. [Except for two studies finding gel + mouthrinse to be more effective than gel alone,] no other combinations of topical fluoride therapy were consistently superior to a single therapy."
Since fluoride can harm brains, kidneys, and more at certain doses, I'm glad people are interested in which therapies are most effective and are seeking the optimal exposure level.
Even in the U.S., toothpaste containers warn you not to swallow it and contact a Poison Control Center if you accidentally do. And then they put it in tap water? It just seems really inconsistent.
Is a pea-sized drop on your toothbrush going to hurt you if you swallow it, no, but there's no reason to swallow toothpaste and a number of mild reasons why you probably shouldn't.
> Keep out of reach of children under 6 years of age. If more than used for brushing is accidentally swallowed, get medical help or contact a Poison Control Center right away.
Note: more than used for brushing
So, it's fine to swallow your toothpaste if you want. But if your 4 year swallows a whole tube of it, they are probably going to get sick to their stomach.
Eating the toothpaste risks "fluorosis" - discoloured teeth. https://en.wikipedia.org/wiki/Dental_fluorosis
Sola dosis facit venenum
Or, 'The dose makes the poison'.. Many things are completely fine in small amounts but are dangerous in larger amounts.Fluoridation for dental health is done at 0.7mg/liter.
The only health effects observed at 4mg/liter are dental fluorosis, staining of teeth as they form in children.
There are places in the United States where the natural drinking water exceeds 4mg/liter. King Hill, Idaho (population 100) wins with 16mg/liter.
http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD010856...
"Generally, in Germany fluoridation of drinking water is forbidden. The relevant German law allows exceptions to the fluoridation ban on application. The argumentation of the Federal Ministry of Health against a general permission of fluoridation of drinking water is the problematic nature of compuls[ory] medication." (Gerda Hankel-Khan, Embassy of Federal Republic of Germany, September 16, 1999).[0]
Germany halted its water fluoridation in the 1970s and France never started.[1]
[0] http://www.slweb.org/50reasons.html [1] http://www.theguardian.com/world/2013/sep/17/water-fluoridat...
In Denmark the water isn't fluoridated, but its natural levels of fluoride are only slightly lower than the levels that U.S. cities add (for example in the Copenhagen water supply, fluoride is around 0.6 mg/L). So it's a bit pedantic to claim that it isn't fluoridated. It's true that the utility company is not adding more fluoride to the water, but the end result is still that the pipes are delivering tap water with fluoride in it.
http://www.hsph.harvard.edu/news/features/fluoride-childrens...
The current target concentration in the US is 0.7mg/L and is routinely monitored and lowered if the background level is too high where some of the 'hot spots' in China that saw childhood development issues had water containing above 6mg/L and one area had a range from 118mg/kg to 1,361mg/kg (thank you coal mining).
Another confounding factor is that many of the areas with high fluoride levels also had high aluminum, mercury, and arsenic levels as well.
I'd like to see a study comparing IQs or development with actual usage levels and without the heavy metal pollutants from industry.
Full HSPH study:
http://ehp.niehs.nih.gov/wp-content/uploads/2012/09/ehp.1104...
> Drinking water may contain other neurotoxicants, such as arsenic, but exclusion of studies including arsenic and iodine as co-exposures in a sensitivity analysis resulted in a lower estimate, although the difference was not significant.
But this story is already off the front page and you succeeded in burying my post and defending fluoride for some strange reason, so you win.
As I understand the article, they're saying that they couldn't find rigorous studies demonstrating the beneficial effects of fluoride. They don't claim there's any evidence against fluoride having beneficial effects, just that the studies haven't been done.
In fact, even discussing the possibility is too much for most people to entertain. They think you're wasting their time with fantasy and falsehood, like conspiracy theorists always do. Fluoride being bad for teeth is as believable as airliners dropping chemtrails everywhere, or jet fuel not "spheroiding" steel after hours of heating.
Edit, I checked. It seems that it might be higher than average.
Everyone should get the right amount of fluoride. This is actually quite difficult to measure and achieve.
WHO seem to have a good viewpoint:
"The effects of fluoride are best predicted by the dose (i.e. mg fluoride per kg of body weight per day), the duration of exposure and other factors such as age (e.g. dental fluorosis). However, most epidemiological studies concerning the effects of fluoride on teeth and bone have correlated the effects with the concentration of fluoride in the drinking-water (mg l–1 fluoride) consumed rather than total fluoride exposure. ... Perhaps the best general advice that can be given in relation to local conditions is that, at a minimum, the fluoride level in local water supplies should be monitored and the population examined for signs of excessive fluoride exposure (e.g. moderate and/or severe dental fluorosis and crippling skeletal fluorosis). Where treatment to remove fluoride is practised, chemicals used should be of a grade suitable for use in drinking-water supply as outlined in the WHO Guidelines for Drinking-water Quality."
http://www.who.int/water_sanitation_health/publications/fluo...
http://www.hsph.harvard.edu/news/features/fluoride-childrens...
Anecdotally, I know a dentist that would work 2 days a week there as a sort of 'import-a-dentist' program, and she thought teeth were, in general, in much worse shape there than Little Rock, AR (3 hours away). Not enough to go on obviously.
I take it you're new here. HN has been "tech reddit" for at least a couple of years now.
(This will probably whoosh miles overhead, too).
Fluorine production was a proxy for uranium production if the only use for fluorine was for uranium production. Couldn't have the Soviets knowing how many atom bombs we were building, so we needed to use it for something else too. Something so massive that it would make it impossible to calculate how much was used for nukes. And so we put it in the water supply as an additive.
[1] http://www.washingtonpost.com/news/speaking-of-science/wp/20...
http://www.amazon.com/The-Fluoride-Deception-Christopher-Bry...
"Concerns over fluoridated drinking water have long been derided as the obsession of McCarthyite cranks. But this muckraking j’accuse asserts that fluoride is indeed a dire threat to public health, one foisted upon the nation by a vast conspiracy—not of Communist agents, but of our very own military-industrial complex. Investigative reporter Bryson revisits the decades-long controversy, drawing on mountains of scientific studies, some unearthed from secret archives of government and corporate laboratories, to question the effects of fluoride and the motives of its leading advocates. The efficacy of fluoridated drinking water in preventing tooth decay, he contends, is dubious. Fluoride in its many forms may be one of the most toxic of industrial pollutants, and Bryson cites scientific analyses linking fluoridated drinking water to bone deformities, hyperactivity and a host of other complaints. The post-war campaign to fluoridate drinking water, he claims, was less a public health innovation than a public relations ploy sponsored by industrial users of fluoride—including the government’s nuclear weapons program. Legendary spin doctors like Edward Bernays exploited the tenuous link between dental hygiene and fluoridation to create markets to stimulate fluoride production and to prove the innocuousness of fluoride compounds, thereby heading off lawsuits by factory workers and others poisoned by industrial fluoride pollution. Bryson marshals an impressive amount of research to demonstrate fluoride’s harmfulness, the ties between leading fluoride researchers and the corporations who funded and benefited from their research, and what he says is the duplicity with which fluoridation was sold to the people. The result is a compelling challenge to the reigning dental orthodoxy, which should provoke renewed scientific scrutiny and public debate."
effluent
For reference, the Fluoride scene in Dr. Strangelove: https://www.youtube.com/watch?v=Qr2bSL5VQgM