So I tried Clojurescript and I liked it as a language. In terms of fit for a compile-to-Javascript language, it is probably the best implementation out there, partially due to Javascript's dynamic lispy origin. But it has a a major problem: It's not Clojure. It might be a Clojure-like language, but its not Clojure. So you still end up "splitting", but when you split you have to squint harder at the details. As far as fidelity to the native language, I've found Scala.js to be much better.

I can't wait for WebAssembly though... it will be a game changer for people that prefer strong static typing for managing logical complexity.